DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sgp and Far1

DIOPT Version :9

Sequence 1:	NP_001260257.1	Gene:	Sgp / 34188	FlyBaseID:	FBgn0032055	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001011933.1	Gene:	Far1 / 293173	RGDID:	1306647	Length:	515	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	168/506 - (33%)
Similarity:	273/506 - (53%)	Gaps:	24/506 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILQFYKDKSVFVTGGTGFLGKVIIEKLLRS-TDVRRVYLLVRPKKNETVEGRFQAWKDEPVFKIL 68
            |.::|:.|::.:||.|||||||::|||||| ..|..||:|||.|..:|.:.|.:......:|..|
  Rat     4 IPEYYEGKNILLTGATGFLGKVLLEKLLRSCPKVNSVYVLVRQKAGQTPQERVEEILSGKLFDRL 68

  Fly    69 LKAKPEALKLVTPISGDCSEPGLGLSDGDRRMVTADVQVIIHSAASIRFVEPLQRALNINTRATR 133
            ....|:..:.:..|:.:.::|.|.||:.|:.::.....||.|.||::||.|.|:.|:.:|..|||
  Rat    69 RDENPDFRQKIIAINSELTQPKLALSEEDKEIIIDSTNVIFHCAATVRFNENLRDAVQLNVIATR 133

  Fly   134 LMIQLAKEMKGLEAFVHISTAFSNCPSQHIEERFYPEHLTCPAAKVLEFNETLSPDLLDKMAPAL 198
            .:|.||::||.||.|:|:|||::.|..:||:|..||..:  ...|:::..|.:...|::.:.|.|
  Rat   134 QLILLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYPPPV--DPKKLIDSLEWMDDGLVNDITPKL 196

  Fly   199 MGKFPNTYTYTKALAEQVIQMEGQDLPICVFRPAIILANFKEPMSGWIDNLHGVVALIYGNTYGI 263
            :|..||||.|||||||.|:|.||..|.:.:.||:|:.|::|||..|||||.:|...|......||
  Rat   197 IGDRPNTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKGI 261

  Fly   264 LRLLYVNPKADAIIVPGDYCANVALASGWQVAKNSESRSSSQLAAKKPPPI--YTLATTKSNSIT 326
            ||.:..:..|.|.:||.|...|.:||:.|....|            :|..|  |...|..:|...
  Rat   262 LRTMRASNNALADLVPVDVVVNTSLAAAWYSGVN------------RPRNIMVYNCTTGSTNPFH 314

  Fly   327 FGKAVKLGIHHNH---TIPVTKTIWYPFAHFTTCPWLFKLGCIFYHLIPGFFFDLLLRIQGKKPI 388
            :|   ::|.:.||   |.|:.:...:|:..|.:...:........|.:|....||.||:.|:||.
  Rat   315 WG---EVGDYLNHSFKTNPLNQVFRHPYVKFYSNNLMLHYWKGVKHTVPALLLDLALRLTGQKPW 376

  Fly   389 LMRSYQKIHEVLLLLFPFNGKTYEMDMNNTNQLWDSMSPEDRSIFPFDMATLNWEEYFTRILSGM 453
            :|::..::|:.::.|..|...::..:.:|.|.|.:.::|||:..|..|:..|:|.||......|.
  Rat   377 MMKTITRLHKAMVFLEYFTSNSWVWNTDNVNMLMNQLNPEDKKTFNIDVRQLHWAEYIENYCMGT 441

  Fly   454 RVFLYKESWDTLEQAKKRLFRFYILHRSLQLVLCLALGKIVWILYSVIANN 504
            :.::..|....|..|:|.|.:...:......:|.:.:.:| :|..|.:|.|
  Rat   442 KKYVLNEEMSGLPAARKHLNKLRNIRYGFNTILVILIWRI-FIARSQMARN 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sgp	NP_001260257.1	PLN02996	1..449	CDD:215538	156/449 (35%)
		FAR-N_SDR_e	12..333	CDD:187547	122/323 (38%)
		FAR_C	367..457	CDD:176924	26/89 (29%)
Far1	NP_001011933.1	PLN02996	2..446	CDD:215538	157/458 (34%)
		FAR-N_SDR_e	11..330	CDD:187547	126/335 (38%)
		Sterile	371..447	CDD:281068	20/75 (27%)
		Necessary and sufficient for PEX19-mediated localization into peroxisome membrane. /evidence=ECO:0000250\|UniProtKB:Q8WVX9	451..507		10/42 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351497
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750