DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba4 and CNX5

DIOPT Version :9

Sequence 1:	NP_001260255.1	Gene:	Uba4 / 34187	FlyBaseID:	FBgn0032054	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_200324.1	Gene:	CNX5 / 835604	AraportID:	AT5G55130	Length:	464	Species:	Arabidopsis thaliana

Alignment Length:	482	Identity:	192/482 - (39%)
Similarity:	279/482 - (57%)	Gaps:	58/482 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SEVDSERTMLKREIAELRAALNQKEQCLRELDSL---------FSFATRPEQEVVGNDLESPDVA 59
            ||:..|...||.:.||:...::..|..|::..::         .|:.|.||.|
plant     9 SEIVRELEELKLKKAEIEHRISTLEAKLQDTAAVELYDAVSNGDSYLTAPELE------------ 61

  Fly    60 VHTKLTNDDIARYSRQLILPDFGVQGQLKLKNSSVLIVGLGGLGCPAAQYLAAAGCGHLGLVDYD 124
             | .|:.|.|.||||||:||.|.|:||..|..||||::|.||||.||..||||.|.|.||::|:|
plant    62 -H-GLSPDQIYRYSRQLLLPSFAVEGQSNLLKSSVLVIGAGGLGSPALLYLAACGVGQLGIIDHD 124

  Fly   125 EVERSNFHRQILHSEDRCGMSKAESARIALLELNPHCEIQCHSRMLYPHNAMHIIRGYDVVLDCT 189
            .||.:|.||||:|:|...|..|.:||..|...:|...::..:...|...||:.|:..||:::|.|
plant   125 VVELNNMHRQIIHTEAFIGHPKVKSAAAACRSINSTIKVDEYVEALRTSNALEILSQYDIIVDAT 189

  Fly   190 DNVPTRYLLSDACVMLSKPLVSGSALKMDGQLTVYNYANGPCYRCIFPVPPPPEAVTNCGDGGVL 254
            ||.|:||::||.||:|.||||||:||.|:|||||||:..||||||:||.|||..|...|.|.|||
plant   190 DNPPSRYMISDCCVLLGKPLVSGAALGMEGQLTVYNHNGGPCYRCLFPTPPPTSACQRCSDSGVL 254

  Fly   255 GAVTGTIGAMQALEAIKVIVGMGDVLAGRLLIFDGGSGVFRNIRIRSKRPNCHMCSAQPLIT--- 316
            |.|.|.||.:||||.||:...:|:.|:.|:|:||..|...|.::||.:...|.:|.......
plant   255 GVVPGVIGCLQALETIKLASLVGEPLSERMLLFDALSARMRIVKIRGRSSQCTVCGDNSSFNKQT 319

  Fly   317 -------ELINYEMFCGMHATDKNNPMLLLSTDERLSVEDYQQKIQ-AQPHLLIDVRPTAEFEIC 373
                   :...:.:|.|        |:.||..:.|:|.:::::.:| .:.|:|:||||:..::|.
plant   320 FKDFDYEDFTQFPLFAG--------PLNLLPAESRISSKEFKEILQKKEQHVLLDVRPSHHYKIV 376

  Fly   374 QLPEAVNVPLVEILDDSYLKRLGKQLEDK-----------ELPIVLVCRRGNDSQIAVQHLR-NR 426
            .||:::|:||..:  ::.|..|...|::|           ...:.:|||||||||.|||:|| :.
plant   377 SLPDSLNIPLANL--ETRLNELTSALKEKGNGHANTESCTNPSVFVVCRRGNDSQRAVQYLRESG 439

  Fly   427 FPTHFVRDLIGGLHAWTNSVDPSFPIY 453
            |.:  .:|:||||.||..:|:|:||.|
plant   440 FDS--AKDIIGGLEAWAANVNPNFPTY 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba4	NP_001260255.1	PRK07878	56..453	CDD:181156	177/419 (42%)
		ThiF_MoeB_HesA_family	71..299	CDD:238386	119/227 (52%)
		RHOD_ThiF	336..453	CDD:238784	47/129 (36%)
CNX5	NP_200324.1	ThiF_MoeB_HesA_family	71..299	CDD:238386	119/227 (52%)
CNX5	NP_200324.1	RHOD_ThiF	338..464	CDD:238784	47/129 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	251	1.000	Domainoid score	I522
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6108
Inparanoid	1	1.050	335	1.000	Inparanoid score	I665
OMA	1	1.010	-	-		QHG53534
OrthoDB	1	1.010	-	-		D1445129at2759
OrthoFinder	1	1.000	-	-		FOG0003489
OrthoInspector	1	1.000	-	-		oto2980
orthoMCL	1	0.900	-	-		OOG6_100543
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2381
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840