DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba4 and UBA7

DIOPT Version :9

Sequence 1:	NP_001260255.1	Gene:	Uba4 / 34187	FlyBaseID:	FBgn0032054	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_003326.2	Gene:	UBA7 / 7318	HGNCID:	12471	Length:	1012	Species:	Homo sapiens

Alignment Length:	225	Identity:	67/225 - (29%)
Similarity:	90/225 - (40%)	Gaps:	40/225 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ELRAALNQKEQCLRE------LDSLFSFATRPEQEVVGNDLESP-DVAVHTKLTNDDIARYSRQL 76
            |:..|:::|...|.:      ||.|      ||.   |..|.|| |.|:..       :||..|:
Human   371 EVLKAISRKFMPLDQWLYFDALDCL------PED---GELLPSPEDCALRG-------SRYDGQI 419

  Fly    77 ILPDFGVQGQLKLKNSSVLIVGLGGLGCPAAQYLAAAG-----CGHLGLVDYDEVERSNFHRQIL 136
            .:  ||...|.||:....|:||.|.:||...:..|..|     .|.|.:||.|.:||||..||.|
Human   420 AV--FGAGFQEKLRRQHYLLVGAGAIGCELLKVFALVGLGAGNSGGLTVVDMDHIERSNLSRQFL 482

  Fly   137 HSEDRCGMSKAESARIALLELNPHCEIQCHSRMLYP--HNAMHI-----IRGYDVVLDCTDNVPT 194
            ......|..|||.|..|...|||..::   ..:.||  ....||     ....|.|....|:...
Human   483 FRSQDVGRPKAEVAAAAARGLNPDLQV---IPLTYPLDPTTEHIYGDNFFSRVDGVAAALDSFQA 544

  Fly   195 RYLLSDACVMLSKPLVSGSALKMDGQLTVY 224
            |..::..|....|||:........|..||:
Human   545 RRYVAARCTHYLKPLLEAGTSGTWGSATVF 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba4	NP_001260255.1	PRK07878	56..453	CDD:181156	55/182 (30%)
		ThiF_MoeB_HesA_family	71..299	CDD:238386	52/166 (31%)
		RHOD_ThiF	336..453	CDD:238784
UBA7	NP_003326.2	ThiF	10..1010	CDD:330201	67/225 (30%)
UBA7	NP_003326.2	2 approximate repeats	23..575		67/225 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810