DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba4 and UBA1

DIOPT Version :9

Sequence 1:	NP_001260255.1	Gene:	Uba4 / 34187	FlyBaseID:	FBgn0032054	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	XP_016885266.1	Gene:	UBA1 / 7317	HGNCID:	12469	Length:	1109	Species:	Homo sapiens

Alignment Length:	204	Identity:	55/204 - (26%)
Similarity:	83/204 - (40%)	Gaps:	29/204 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 LTNDDIA----RYSRQLILPDFGVQGQLKLKNSSVLIVGLGGLGCPAAQYLA--AAGCGHLG--- 119
            ||.|...    ||..|:.:  ||...|.||......:||.|.:||...:..|  ..|||..|
Human   490 LTEDKCLQRQNRYDGQVAV--FGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEII 552

  Fly   120 LVDYDEVERSNFHRQILHSEDRCGMSKAESARIALLELNPHCEIQCHSRMLYPHNAM----HIIR 180
            :.|.|.:|:||.:||.|.........|:::|..|:.::|||..:..|...:.|....    ...:
Human   553 VTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDDFFQ 617

  Fly   181 GYDVVLDCTDNVPTRYLLSDACVMLSKPLVSGSALKMDGQLTVY------NYANGPCYRCIFPVP 239
            ..|.|.:..|||..|..:...||...|||:....|...|.:.|.      :|::..        .
Human   618 NLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQ--------D 674

  Fly   240 PPPEAVTNC 248
            ||.:::..|
Human   675 PPEKSIPIC 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba4	NP_001260255.1	PRK07878	56..453	CDD:181156	55/204 (27%)
		ThiF_MoeB_HesA_family	71..299	CDD:238386	52/193 (27%)
		RHOD_ThiF	336..453	CDD:238784
UBA1	XP_016885266.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810