DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uba4 and Uba5

DIOPT Version :9

Sequence 1:	NP_001260255.1	Gene:	Uba4 / 34187	FlyBaseID:	FBgn0032054	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_079968.2	Gene:	Uba5 / 66663	MGIID:	1913913	Length:	403	Species:	Mus musculus

Alignment Length:	378	Identity:	90/378 - (23%)
Similarity:	141/378 - (37%)	Gaps:	97/378 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 YSRQLILPDFG-VQGQLKLKNSSVLIVGLGGLGCPAAQYLAAAGCGHLGLVDYDEVERSNFHRQI 135
            |||.:.|...| |....|::..:|.|||:||:|...|:.|...|.|.|.|.|||:||.:|.:| :
Mouse    51 YSRLMALKRMGIVSDYKKIRTYAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNR-L 114

  Fly   136 LHSEDRCGMSKAESARIALLELNPHCEIQCHSRML-----YPHNAMHIIRG-------YDVVLDC 188
            .....:.|:||..:|...|..:||....:.|:..:     :.|....|..|       .|:||.|
Mouse   115 FFQPYQAGLSKVHAAEHTLRNINPDVLFEVHNYNITTVEHFEHFMNRISNGGLEEGQPVDLVLSC 179

  Fly   189 TDNVPTRYLLSDACVMLSKP-LVSG-SALKMDGQLTVYNYANGPCYRCIFPVPPPPEAVTNCGD- 250
            .||...|..::.||..|.:. :.|| |...:.|.:.:.......|:.|    .||....:|..:
Mouse   180 VDNFEARMAINTACNELGQTWMESGVSENAVSGHIQLMIPGESACFAC----APPLVVASNIDEK 240

  Fly   251 ----GGVLGA----VTGTIGAMQALEAIKVIVGMGDVLAGRLLIFDGGSGVFRNIRIRSKRPNCH 307
                .||..|    ..|.:..:.....:|.::..|.|  ...|.::.....|..:.:: ..|.|
Mouse   241 TLKREGVCAASLPTTMGVVAGILVQNVLKFLLKFGTV--SFYLGYNAMQDFFPTMFMK-PNPQC- 301

  Fly   308 MCSAQPLITELINYEMFCGMHATDKNNPMLLLSTDERLSVEDYQQKIQAQPHLLIDVRPTAEFEI 372
                                  .|||.         |...|:|:::..|        .||.|.|.
Mouse   302 ----------------------DDKNC---------RKQQEEYKKRAAA--------LPTQEAEP 327

  Fly   373 CQLPEAVNVPLVEILDDSYLKRLGKQLEDKELPIVLVCRRGNDSQIAVQHLRN 425
            .:..|.|:                   ||.|..|.||      |:::.:.|:|
Mouse   328 QEEAEVVH-------------------EDNEWGIELV------SEVSEEELKN 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba4	NP_001260255.1	PRK07878	56..453	CDD:181156	90/378 (24%)
		ThiF_MoeB_HesA_family	71..299	CDD:238386	66/250 (26%)
		RHOD_ThiF	336..453	CDD:238784	19/90 (21%)
Uba5	NP_079968.2	ThiF_MoeB_HesA_family	50..293	CDD:238386	66/248 (27%)
		ThiF	51..307	CDD:279270	71/295 (24%)
		UFM1-interacting sequence (UIS). /evidence=ECO:0000250\|UniProtKB:Q9GZZ9	333..345		5/30 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810