DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba4 and Mocs3

DIOPT Version :9

Sequence 1:	NP_001260255.1	Gene:	Uba4 / 34187	FlyBaseID:	FBgn0032054	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_001101274.1	Gene:	Mocs3 / 311655	RGDID:	1307044	Length:	458	Species:	Rattus norvegicus

Alignment Length:	459	Identity:	222/459 - (48%)
Similarity:	304/459 - (66%)	Gaps:	27/459 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EIAELRAALNQKEQCLRELDSL-----FSFATRPEQEVVGNDLESPDVAVHTKLTNDDIARYSRQ 75
            ::|.|:..:.::|:   ||.||     .:.|..||.|.....:..|..|.   |:.|:|.|||||
  Rat     6 DVAALQDEIARREE---ELASLKQRLAAALAVEPEPERPIPVMPLPSRAA---LSRDEILRYSRQ 64

  Fly    76 LILPDFGVQGQLKLKNSSVLIVGLGGLGCPAAQYLAAAGCGHLGLVDYDEVERSNFHRQILHSED 140
            |:||:.||:|||:|..:|||:||.||||||.||||||||.|.|||||:|.||.||..||:||.|.
  Rat    65 LLLPELGVRGQLRLAAASVLVVGCGGLGCPLAQYLAAAGVGRLGLVDHDVVETSNLARQVLHGEA 129

  Fly   141 RCGMSKAESARIALLELNPHCEIQCHSRMLYPHNAMHIIRGYDVVLDCTDNVPTRYLLSDACVML 205
            :.|.:||.||..||..||...|...::|.|....|:.::||||||.||:||||||||::||||:.
  Rat   130 QAGHAKAWSAAAALRRLNSAVEYVPYARALSEAWALDLVRGYDVVADCSDNVPTRYLVNDACVLA 194

  Fly   206 SKPLVSGSALKMDGQLTVYNYANGPCYRCIFPVPPPPEAVTNCGDGGVLGAVTGTIGAMQALEAI 270
            .:||||.|||:.:||:|||:|.:||||||:||.|||.|.||||.||||||.|.|.:|.:||||.:
  Rat   195 GRPLVSASALRFEGQMTVYHYDDGPCYRCVFPRPPPAETVTNCADGGVLGVVPGVLGCVQALEVL 259

  Fly   271 KVIVGMGDVLAGRLLIFDGGSGVFRNIRIRSKRPNCHMCSAQPLITELINYEMFCGMHATDKNNP 335
            |:..|:|...:|.:|:|||..|.||.||:|.:||:|.:|..||.:|.|.|||.|||..||||...
  Rat   260 KIAAGLGTTYSGSMLLFDGLGGHFRRIRLRRRRPDCVVCGQQPTVTCLKNYEAFCGSSATDKCRS 324

  Fly   336 MLLLSTDERLSVEDYQQKIQA-QPHLLIDVRPTAEFEICQLPEAVNVP--LVEILDDSYLKRLGK 397
            :.|||.:||:||.||::.:.: .||:|:||||..|.:||:|..::::|  |:|..|...||.||.
  Rat   325 LKLLSPEERISVTDYKRLLDSGVPHVLLDVRPQVEVDICRLQHSLHIPLSLLERRDADSLKLLGA 389

  Fly   398 QLEDKE--------LPIVLVCRRGNDSQIAVQHLRN-----RFPTHFVRDLIGGLHAWTNSVDPS 449
            .|::::        |.:.::|:.|||||.||:.|::     ...:..|:|:.|||.||...:|.:
  Rat   390 ALQEEKRNSQEGAALAVYVICKLGNDSQKAVRVLQSLTAVPELDSLKVQDISGGLMAWAAKIDGT 454

  Fly   450 FPIY 453
            ||.|
  Rat   455 FPQY 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba4	NP_001260255.1	PRK07878	56..453	CDD:181156	210/412 (51%)
		ThiF_MoeB_HesA_family	71..299	CDD:238386	136/227 (60%)
		RHOD_ThiF	336..453	CDD:238784	49/132 (37%)
Mocs3	NP_001101274.1	PRK07411	53..458	CDD:180967	208/404 (51%)
		ThiF_MoeB_HesA_family	60..283	CDD:238386	133/222 (60%)
		RHOD_ThiF	325..458	CDD:238784	49/132 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353856
Domainoid	1	1.000	295	1.000	Domainoid score	I1430
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6108
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1774
OMA	1	1.010	-	-		QHG53534
OrthoDB	1	1.010	-	-		D1445129at2759
OrthoFinder	1	1.000	-	-		FOG0003489
OrthoInspector	1	1.000	-	-		oto97610
orthoMCL	1	0.900	-	-		OOG6_100543
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2381
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770