DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba4 and SPAC2G11.10c

DIOPT Version :9

Sequence 1:	NP_001260255.1	Gene:	Uba4 / 34187	FlyBaseID:	FBgn0032054	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_593090.1	Gene:	SPAC2G11.10c / 2541739	PomBaseID:	SPAC2G11.10c	Length:	401	Species:	Schizosaccharomyces pombe

Alignment Length:	424	Identity:	177/424 - (41%)
Similarity:	249/424 - (58%)	Gaps:	39/424 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 PEQEVV--GNDLESPDVAVHTKLTNDDIARYSRQLILPDFGVQGQLKLKNSSVLIVGLGGLGCPA 106
            |:::::  .|.||         |:.|:.:||.||::|.:.|:.|||.||.||||::|.|||||||
pombe     3 PQEKIICSSNGLE---------LSLDEYSRYGRQMLLSEIGLPGQLSLKRSSVLVIGAGGLGCPA 58

  Fly   107 AQYLAAAGCGHLGLVDYDEVERSNFHRQILHSEDRCGMSKAESARIALLELNPHCEIQCHSRMLY 171
            .|||.|||.|.||::|.|.|::||.||||:||..:.||.||.||:..|.:|||:..|..:.....
pombe    59 MQYLVAAGIGTLGIMDGDVVDKSNLHRQIIHSTSKQGMHKAISAKQFLEDLNPNVIINTYLEFAS 123

  Fly   172 PHNAMHIIRGYDVVLDCTDNVPTRYLLSDACVMLSKPLVSGSALKMDGQLTVYNYANGPCYRCIF 236
            ..|...||..||||||||||..||||:||.||:|.:||||.||||::|||.:|||.|||||||:|
pombe   124 ASNLFSIIEQYDVVLDCTDNQYTRYLISDTCVLLGRPLVSASALKLEGQLCIYNYCNGPCYRCMF 188

  Fly   237 PVPPPPEAVTNCGDGGVLGAVTGTIGAMQALEAIKVIVGMGDVLAGR----LLIFDGGS-GVFRN 296
            |.|.|  .|.:|...|:||.|.||:|.|||||.:|:|:.:..:...:    :|:|.... ..:::
pombe   189 PNPTP--VVASCAKSGILGPVVGTMGTMQALETVKLILHINGIKKDQFDPYMLLFHAFKVPQWKH 251

  Fly   297 IRIRSKRPNCHMCSAQPLITELI------NYEMFCGMHATDKNNPMLLLSTDERLSVEDYQQKIQ 355
            ||||.::.:|..|....:::...      .|...|....|....    |:...|:|..|.:..|:
pombe   252 IRIRPRQQSCKACGPNKMLSREFMESSPKEYTTICDYVPTLSKQ----LAPIRRISALDLKNLIE 312

  Fly   356 AQPHL-LIDVRPTAEFEICQLPEAVNVPLVEILDDSYLKRLGKQLEDKELPIVLVCRRGNDSQIA 419
            ..||: .:|||...:|.||:||...|:||.|:  ||.....||        :.::||.||.||.|
pombe   313 TSPHITFLDVREPVQFGICRLPLFKNIPLSEV--DSLQNLSGK--------VCVICRSGNTSQTA 367

  Fly   420 VQHLRNRFPTHFVRDLIGGLHAWTNSVDPSFPIY 453
            |:.|:...|...:.|::.||..|:..|||:||:|
pombe   368 VRKLQELNPQADIFDVVAGLKGWSTEVDPNFPLY 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba4	NP_001260255.1	PRK07878	56..453	CDD:181156	172/408 (42%)
		ThiF_MoeB_HesA_family	71..299	CDD:238386	120/232 (52%)
		RHOD_ThiF	336..453	CDD:238784	42/117 (36%)
SPAC2G11.10c	NP_593090.1	ThiF	15..266	CDD:223552	128/261 (49%)
		ThiF_MoeB_HesA_family	23..254	CDD:238386	120/232 (52%)
		RHOD_ThiF	293..401	CDD:238784	42/121 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	240	1.000	Domainoid score	I455
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6108
Inparanoid	1	1.050	316	1.000	Inparanoid score	I559
OMA	1	1.010	-	-		QHG53534
OrthoFinder	1	1.000	-	-		FOG0003489
OrthoInspector	1	1.000	-	-		oto101524
orthoMCL	1	0.900	-	-		OOG6_100543
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1579
SonicParanoid	1	1.000	-	-		X2381
TreeFam	1	0.960	-	-
	14	13.860