DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uba4 and mocs3

DIOPT Version :9

Sequence 1:	NP_001260255.1	Gene:	Uba4 / 34187	FlyBaseID:	FBgn0032054	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	XP_031758108.1	Gene:	mocs3 / 100491723	XenbaseID:	XB-GENE-5804173	Length:	455	Species:	Xenopus tropicalis

Alignment Length:	431	Identity:	216/431 - (50%)
Similarity:	282/431 - (65%)	Gaps:	28/431 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 GNDLES-------------PDVAVHTKLTNDDIARYSRQLILPDFGVQGQLKLKNSSVLIVGLGG 101
            ||:::|             |::. .:.|||.||.||||||:||:|||||||.|...|||::|.||
Frog    26 GNEVKSYSLPESHGADEILPELN-KSSLTNPDILRYSRQLVLPEFGVQGQLNLSKVSVLVIGCGG 89

  Fly   102 LGCPAAQYLAAAGCGHLGLVDYDEVERSNFHRQILHSEDRCGMSKAESARIALLELNPHCEIQCH 166
            ||||.||||||:|.|.|||:|||.||.||.|||:||.|:|.||.|:.|....|.:||.......:
Frog    90 LGCPVAQYLAASGIGRLGLLDYDVVEMSNLHRQVLHGENRLGMPKSVSIVKTLQKLNSSVIYLPY 154

  Fly   167 SRMLYPHNAMHIIRGYDVVLDCTDNVPTRYLLSDACVMLSKPLVSGSALKMDGQLTVYNYANGPC 231
            ...|.|.|.:.|||.||::.||:||||||||::||||:..|||||.|||:.:||||||||..|||
Frog   155 HMSLNPENGLQIIRQYDIIADCSDNVPTRYLVNDACVLAGKPLVSASALRWEGQLTVYNYQQGPC 219

  Fly   232 YRCIFPVPPPPEAVTNCGDGGVLGAVTGTIGAMQALEAIKVIVGMGDVLAGRLLIFDGGSGVFRN 296
            |||:||.|||.|.||||.||||||.|.|.||::||||.:|:..||....:|.||:||...|.|||
Frog   220 YRCLFPKPPPSETVTNCADGGVLGIVPGIIGSLQALEVLKIASGMVPSYSGVLLMFDALEGRFRN 284

  Fly   297 IRIRSKRPNCHMCSAQPLITELINYEMFCGMHATDKNNPMLLLSTDERLSVEDYQQKIQAQ-PHL 360
            |:||.|:.:|..||.......|.:||.|||..|:||...:.|||.|||||||:|::.:... ||:
Frog   285 IKIRGKQNDCAACSNSAETAILQDYEAFCGSSASDKCRMLSLLSRDERLSVEEYKRLLDDHIPHI 349

  Fly   361 LIDVRPTAEFEICQLPEAVNVPL--VEILDDSYLKRLGKQLED-------KELPIVLVCRRGNDS 416
            ||||||..|.:|||||.::::||  :|..::.::..|..::.:       .|..::.:|:.||||
Frog   350 LIDVRPQPEVDICQLPHSIHIPLKGLEQKNEKWISFLRTKIAELINTGNRVEKTVITICKLGNDS 414

  Fly   417 QIAVQHLR----NRFPTHFVRDLIGGLHAWTNSVDPSFPIY 453
            ||||:.|:    |......|:|:.|||.||...:||.||.|
Frog   415 QIAVKILQEIFGNEVDLFVVKDVQGGLMAWAEKIDPMFPRY 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba4	NP_001260255.1	PRK07878	56..453	CDD:181156	212/410 (52%)
		ThiF_MoeB_HesA_family	71..299	CDD:238386	139/227 (61%)
		RHOD_ThiF	336..453	CDD:238784	52/130 (40%)
mocs3	XP_031758108.1	ThiF_MoeB_HesA_family	59..287	CDD:238386	139/227 (61%)
mocs3	XP_031758108.1	RHOD	324..455	CDD:412175	52/130 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	295	1.000	Domainoid score	I1466
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6108
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1807
OMA	1	1.010	-	-		QHG53534
OrthoDB	1	1.010	-	-		D1445129at2759
OrthoFinder	1	1.000	-	-		FOG0003489
OrthoInspector	1	1.000	-	-		oto104296
Panther	1	1.100	-	-	LDO	PTHR10953
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2381
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080