DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIG-U and pigu

DIOPT Version :9

Sequence 1:	NP_609238.1	Gene:	PIG-U / 34185	FlyBaseID:	FBgn0032052	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_001171884.1	Gene:	pigu / 560242	ZFINID:	ZDB-GENE-100629-1	Length:	435	Species:	Danio rerio

Alignment Length:	437	Identity:	169/437 - (38%)
Similarity:	259/437 - (59%)	Gaps:	27/437 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLLGGAVRFYFCRTPLAPMIGNRVEFATPLNSHKRMQEGIFLLQSGIDPYLGDLVHESPLILSA 72
            |||:...:|....|:.||.:|..|||..:|||:.||:.||:.||..|:.||.||:.||:||::.
Zfish     8 LLLVAVTIRGVLFRSNLAEIISERVEVVSPLNAWKRVVEGLALLDLGVSPYSGDVFHETPLMIY- 71

  Fly    73 LSGLFQKYPQFLPIFYIILDICTAALLYAMSLRFVKQKQDQQDK---ERKEYAKDTEELQFGPLD 134
               ||.....:..|.::|.|..||..|| :|::...:...::.|   |.:.|..|..||...|.:
Zfish    72 ---LFHFLVDYAEIVFMIADGITAVALY-LSVQIYNKNVFRKQKYALESERYPADCLELLRSPKE 132

  Fly   135 KLDIPELVIVAYLFSPLTVMSCIGMTSTVISNLFLAFFFYCLVKGMLIPCLLVLAFETVRSFYPI 199
            ...||..|.:.||.:|.|::||:..::..::|..:|.|..|.:||..:...::||..|.:|.||:
Zfish   133 MFYIPLKVAMFYLLNPFTILSCVAKSTCGLNNAIIALFILCTLKGSALLSGILLALATYQSMYPL 197

  Fly   200 VLIAPLLLVFSRN-----SVRRG------VAIAALFIVSCLIVAVANYFVLNSWNFLDGTLGFIF 253
            .|.||.||.|.:.     ::||.      :..|.::..|.:::...::|:|.||:|:....|||.
Zfish   198 TLFAPALLFFLQRLYIPVNLRRSSFWFFTLQYAFIYFGSLIVITGLSFFLLGSWDFIPSVYGFIL 262

  Fly   254 YFRDLQPNIGLFWYFFTEMFEHFRTMFLITFQLNATVLYLVPLSIKLRKEPLLLATVLVALMAVF 318
            ...||.||||||||||.|||||||..|:..||:| ...|.:||||||::.|:.|..:.:|::::|
Zfish   263 SVPDLTPNIGLFWYFFAEMFEHFRLFFICVFQIN-VFFYTIPLSIKLKEHPVFLMFMQIAIISIF 326

  Fly   319 RAYPSLGDVGFYLALLPLWKRCWKFMAHGFVVFTFFLVTLSMMGALWHLWIYAGSANANFYFGAT 383
            ::||::|||..|:|.||.|...::|:.:.|:|....|...::...||||||||||||:|||:..|
Zfish   327 KSYPTVGDVALYMAFLPAWSHLYRFLRNIFLVSCVLLACSALFPVLWHLWIYAGSANSNFYYAIT 391

  Fly   384 LAFSTGQIFLITDLLFAHVKREFCLFNG----QKILIDGEEARIVLK 426
            |.|:.|||.|::|..:|:::||..|.:|    :|   ||.||.:|||
Zfish   392 LLFNFGQILLVSDYFYAYLRREHHLTHGLYLKKK---DGTEATLVLK 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-U	NP_609238.1	PIG-U	10..386	CDD:284205	148/389 (38%)
pigu	NP_001171884.1	PIG-U	15..394	CDD:284205	147/384 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594377
Domainoid	1	1.000	282	1.000	Domainoid score	I1621
eggNOG	1	0.900	-	-		E1_KOG2552
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6553
Inparanoid	1	1.050	313	1.000	Inparanoid score	I2559
OMA	1	1.010	-	-		QHG54393
OrthoDB	1	1.010	-	-		D1339553at2759
OrthoFinder	1	1.000	-	-		FOG0004125
OrthoInspector	1	1.000	-	-		oto41261
orthoMCL	1	0.900	-	-		OOG6_103076
Panther	1	1.100	-	-	LDO	PTHR13121
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R924
SonicParanoid	1	1.000	-	-		X2867
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800