DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIG-U and pigu-1

DIOPT Version :9

Sequence 1:	NP_609238.1	Gene:	PIG-U / 34185	FlyBaseID:	FBgn0032052	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_492189.2	Gene:	pigu-1 / 172565	WormBaseID:	WBGene00011914	Length:	421	Species:	Caenorhabditis elegans

Alignment Length:	392	Identity:	118/392 - (30%)
Similarity:	199/392 - (50%)	Gaps:	51/392 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 RVEFATPLNSHKRMQEGIFLLQSGIDPYLGDLVHESPLILSALSGLFQKYP-QFLPIFYIILDIC 94
            |||..:.:.|.:::::.|.::..|::|:....:|..||.|.....|....| ..||:| |.:|:.
Worm    50 RVELTSVVYSFEKLKDSIAMVDDGLNPFEAKNMHFPPLTLHLFRFLLNTAPTMILPLF-ISIDVA 113

  Fly    95 TAALLYAMSLRFVKQKQDQQDKERKEYAKDTEELQFGPLDKLDIPELVIVAYLFSPLTVMSCIGM 159
            |..:|.:.:....:|.....                      .|.:|:...|.|:|:|::|...:
Worm   114 TTWILSSAADVVWRQTHGSS----------------------SIRKLIFSLYAFNPITIVSTGIL 156

  Fly   160 TSTVISNLFLAFFFYCLVKGMLIPCLLVLAFETVRSFYPIVLIAPLLLVF-SRNSVRRGVAIAAL 223
            :.|||.|...|.....||......|.:::...:..:.||.:||:  .||| |..|:   |...:|
Worm   157 SLTVIQNFVSAVILLSLVTDRPTICAILIGAWSSFTIYPFILIS--CLVFRSNGSI---VKFLSL 216

  Fly   224 FIVSCL--IVAVANYFVLN--SWNFLDGTLGFIFYFRDLQPNIGLFWYFFTEMFEHFRTMFLITF 284
            .:||.|  |..|...::||  |.|||......|..|..:|||.||:||||.::|||||:.:.::|
Worm   217 VLVSALTTITFVGINYLLNNQSLNFLGPVYASILNFSSIQPNSGLYWYFFVQIFEHFRSFYTMSF 281

  Fly   285 QLNATVLYL---VPLSIKLRKEPLLLATVLVALMAVFRAYPSLGDVGFYLALLP---LWKRCWKF 343
                .|||.   :|::..:||:.:|..|::..|:::|..||:|..|...||.||   ::|:.:::
Worm   282 ----VVLYFFMPIPITFLIRKDTILHFTIIGFLVSIFFPYPTLNQVSLLLAFLPVHDVYKKHFRY 342

  Fly   344 --MAHGFVVFTFFLVTLSMMGALWHLWIYAGSANANFYFGATLAFSTGQIFLITDLLFAHVKREF 406
              :..|.:|.|.||     |..:||:||.:.|.||||:||.|:.::...|.|:.|::|.:.:|:.
Worm   343 TILIAGTIVSTVFL-----MPVMWHMWIVSSSGNANFFFGTTIVYNVALINLVMDMIFVYSRRQI 402

  Fly   407 CL 408
            .|
Worm   403 DL 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-U	NP_609238.1	PIG-U	10..386	CDD:284205	112/368 (30%)
pigu-1	NP_492189.2	PIG-U	32..382	CDD:284205	112/368 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166110
Domainoid	1	1.000	158	1.000	Domainoid score	I2510
eggNOG	1	0.900	-	-		E1_KOG2552
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6553
Inparanoid	1	1.050	170	1.000	Inparanoid score	I2757
Isobase	1	0.950	-	0	Normalized mean entropy	S1982
OMA	1	1.010	-	-		QHG54393
OrthoDB	1	1.010	-	-		D1339553at2759
OrthoFinder	1	1.000	-	-		FOG0004125
OrthoInspector	1	1.000	-	-		oto17762
orthoMCL	1	0.900	-	-		OOG6_103076
Panther	1	1.100	-	-	LDO	PTHR13121
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R924
SonicParanoid	1	1.000	-	-		X2867
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750