DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIG-U and PIGU

DIOPT Version :9

Sequence 1:	NP_609238.1	Gene:	PIG-U / 34185	FlyBaseID:	FBgn0032052	Length:	426	Species:	Drosophila melanogaster
Sequence 2:	NP_536724.1	Gene:	PIGU / 128869	HGNCID:	15791	Length:	435	Species:	Homo sapiens

Alignment Length:	433	Identity:	164/433 - (37%)
Similarity:	250/433 - (57%)	Gaps:	19/433 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLLGGAVRFYFCRTPLAPMIGNRVEFATPLNSHKRMQEGIFLLQSGIDPYLGDLVHESPLILSA 72
            :|::...||....|:.||..|..|||..:||:|.||:.||:.||..|:.||.|.:.||:|||:.
Human     8 VLVVAVTVRAALFRSSLAEFISERVEVVSPLSSWKRVVEGLSLLDLGVSPYSGAVFHETPLIIY- 71

  Fly    73 LSGLFQKYPQFLPIFYIILDICTAALLYAMSLRFVKQ--KQDQQDKERKEYAKDTEELQFGPLDK 135
               ||.....:..:.::|.|..||..||.....|.|.  |:.:...|..:||.|..||...|::.
Human    72 ---LFHFLIDYAELVFMITDALTAIALYFAIQDFNKVVFKKQKLLLELDQYAPDVAELIRTPMEM 133

  Fly   136 LDIPELVIVAYLFSPLTVMSCIGMTSTVISNLFLAFFFYCLVKGMLIPCLLVLAFETVRSFYPIV 200
            ..||..|.:.||.:|.|::||:..::..|:|..:|||....:||......:.||..|.:|.||:.
Human   134 RYIPLKVALFYLLNPYTILSCVAKSTCAINNTLIAFFILTTIKGSAFLSAIFLALATYQSLYPLT 198

  Fly   201 LIAP-LLLVFSRNSV---RRGVAI-------AALFIVSCLIVAVANYFVLNSWNFLDGTLGFIFY 254
            |..| ||.:..|..:   .:..|.       |.:::.|.:::...::|:|:||:|:....|||..
Human   199 LFVPGLLYLLQRQYIPVKMKSKAFWIFSWEYAMMYVGSLVVIICLSFFLLSSWDFIPAVYGFILS 263

  Fly   255 FRDLQPNIGLFWYFFTEMFEHFRTMFLITFQLNATVLYLVPLSIKLRKEPLLLATVLVALMAVFR 319
            ..||.||||||||||.||||||...|:..||:| ...|.:||:|||::.|:....:.:|::|:|:
Human   264 VPDLTPNIGLFWYFFAEMFEHFSLFFVCVFQIN-VFFYTIPLAIKLKEHPIFFMFIQIAVIAIFK 327

  Fly   320 AYPSLGDVGFYLALLPLWKRCWKFMAHGFVVFTFFLVTLSMMGALWHLWIYAGSANANFYFGATL 384
            :||::|||..|:|..|:|...::|:.:.||:....:|...:...||||||||||||:||::..||
Human   328 SYPTVGDVALYMAFFPVWNHLYRFLRNIFVLTCIIIVCSLLFPVLWHLWIYAGSANSNFFYAITL 392

  Fly   385 AFSTGQIFLITDLLFAHVKREFCLFNGQKILI-DGEEARIVLK 426
            .|:.|||.||:|..:|.::||:.|.:|..:.. ||.||.:|||
Human   393 TFNVGQILLISDYFYAFLRREYYLTHGLYLTAKDGTEAMLVLK 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-U	NP_609238.1	PIG-U	10..386	CDD:284205	144/388 (37%)
PIGU	NP_536724.1	PIG-U	20..394	CDD:369053	142/378 (38%)
PIGU	NP_536724.1	May be involved in recognition of long-chain fatty acids in GPI	269..289		16/19 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158450
Domainoid	1	1.000	271	1.000	Domainoid score	I1823
eggNOG	1	0.900	-	-		E1_KOG2552
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6553
Inparanoid	1	1.050	302	1.000	Inparanoid score	I2686
Isobase	1	0.950	-	0	Normalized mean entropy	S1982
OMA	1	1.010	-	-		QHG54393
OrthoDB	1	1.010	-	-		D1339553at2759
OrthoFinder	1	1.000	-	-		FOG0004125
OrthoInspector	1	1.000	-	-		oto90024
orthoMCL	1	0.900	-	-		OOG6_103076
Panther	1	1.100	-	-	LDO	PTHR13121
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R924
SonicParanoid	1	1.000	-	-		X2867
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750