DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13097 and Mphosph10

DIOPT Version :9

Sequence 1:	NP_609237.1	Gene:	CG13097 / 34184	FlyBaseID:	FBgn0032051	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_080759.2	Gene:	Mphosph10 / 67973	MGIID:	1915223	Length:	681	Species:	Mus musculus

Alignment Length:	702	Identity:	262/702 - (37%)
Similarity:	370/702 - (52%)	Gaps:	105/702 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 TKNPERFLQPQPEQVNAIEQLIQQTYAVS-ISEDVANKKELLPELVLEQMDEEQIWQQLEIRNEL 87
            |..||.||..|....:....|.:..|..: :.|:.......|.:|.:...|:||||||||::||.
Mouse    22 TNRPECFLTIQNGLASNFTSLTKVLYDFNKVLENGRISGSPLQKLEINSFDDEQIWQQLELQNEP 86

  Fly    88 V---FQQVLEQTARLTAMREQHLGI--ELDDGEEIEEEDEVIQAEDSG------DEEQ--DEESD 139
            |   ||..:.:|     :.::.:.:  |.:| ||.||:...::|::..      ||||  ||..|
Mouse    87 VLQYFQNAVSET-----VEDEDISLLPECED-EECEEDASEVEADNQENLETDLDEEQLSDEGGD 145

  Fly   140 ---------------------FSDEDGGLQ----------KQKTAPPKDKRNKRLRNSVVDDTFF 173
                                 |||||..|.          |.:..||...|.|    |||||.||
Mouse   146 VPKGRDRAKSSRKSDPRKSPVFSDEDSDLDFDIGKLEQQTKMQIKPPGKPREK----SVVDDKFF 206

  Fly   174 KLEEMNEFLEQEDAKEMRRLNSKKRVEQADDIDHFAEDFGLGEDEEDDEEGNVNYADFFDMNEEL 238
            ||.||..|||:.:.:|.:|.:.::  |..:|||.| ||.     :.|:.||.:       ...:.
Mouse   207 KLSEMESFLEKVEKEEEKRPDGEE--EDEEDIDLF-EDI-----DSDESEGGL-------FGRQK 256

  Fly   239 TEHSKKINKGKQKDFFNENES-------ENENEPDEDANPKEGDSDQSEGDEGDDEPENDQDPDE 296
            .:.:|.....|.||||:..||       :.|..|||:...:||.:::::....|.:.:||.:.||
Mouse   257 IKSNKSSRNLKYKDFFDPVESDEDITGVDEELGPDEEKEEEEGFAEEADESISDTDEDNDLEEDE 321

  Fly   297 AASEIDESEFVAKSGIEPASDSDSDSEKEEEEPQPTEPPS---QSSNEMREARLFQRIRDYEDIV 358
            .:.:       .|..::..:.:..|.|.|:..|...:..|   :||.|.|:.::.::|...|..:
Mouse   322 NSDQ-------HKGSLKRVTFALPDDEAEDTSPLAVKQESDEVKSSFEKRQEKMNEKIASLEKEL 379

  Fly   359 LGEKPWQLKGEVKAANRPQNSLLEEILDFDSTTRPTAPITEEDNRSIEDIIKQRIRDKAWDDVER 423
            |.:|||||:|||.|..||:||||||.|.||...|....||||....:||||||||||:|||||||
Mouse   380 LDKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLHLEDIIKQRIRDQAWDDVER 444

  Fly   424 TVRPVNTPQEYRKQLVLDQEKSKQSLSQIYEAQYQREMEKLDPNRDADDKTGPEPKEHQEIKRAM 488
            ..:|.....||:|:|.||.||||.||::|||.:|.    ||:..: .:::..|   ||.||::.|
Mouse   445 KEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYL----KLNQQK-TEEEDNP---EHVEIQKMM 501

  Fly   489 RSLFLKLDALSNFHFTPKPVAPEIKIVTNTPAVHMEEVAPLAVSDAKLLAPEEVFRGPKHAPLGK 553
            .||||||||||||||.|||..||||:|:|.||:.||||||::||||.||||||:....|...| |
Mouse   502 DSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDL-K 565

  Fly   554 T--ERDRTDKNRERRKKKQKQRAIHSALEQRE--LQRAKEGKAPTKKEADAKLLKTITKNRNVQK 614
            |  |:..|||.|||||||.::|......|:|:  |::....::.:.:.|.::.||.:||...|..
Mouse   566 TAAEKTATDKKRERRKKKYQKRLKIKEKEKRKKLLEKNNPDQSKSSRAAASEKLKQLTKTGKVSL 630

  Fly   615 INASSNDQGALKSSKAFFHKLQDTAAATAS-KKRP---KKDTAKADAKKLKL 662
            :.....|: .||||:|||.||||......: .|:|   ||........||||
Mouse   631 LKDERKDK-PLKSSQAFFSKLQDQVKMQINDAKQPEKIKKKKQDISVHKLKL 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13097	NP_609237.1	Mpp10	23..616	CDD:281935	242/650 (37%)
Mphosph10	NP_080759.2	Mpp10	22..632	CDD:281935	242/650 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	111..202		26/95 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..256		14/55 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	268..365		26/103 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..644		29/85 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..681		6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843213
Domainoid	1	1.000	349	1.000	Domainoid score	I1025
eggNOG	1	0.900	-	-		E1_COG5384
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2260
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005050
OrthoInspector	1	1.000	-	-		oto93508
orthoMCL	1	0.900	-	-		OOG6_102269
Panther	1	1.100	-	-	LDO	PTHR17039
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R742
SonicParanoid	1	1.000	-	-		X4693
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.780