DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bace and MKC7

DIOPT Version :9

Sequence 1:	NP_001285756.1	Gene:	Bace / 34182	FlyBaseID:	FBgn0032049	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_010428.3	Gene:	MKC7 / 851722	SGDID:	S000002551	Length:	596	Species:	Saccharomyces cerevisiae

Alignment Length:	483	Identity:	115/483 - (23%)
Similarity:	183/483 - (37%)	Gaps:	138/483 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TIAVVVLL--AALASAELHRVPILK------EQNFVK----TRQNVLAE---KSYLRTK---YQL 50
            |..|..||  :::..|.:...|.|.      :.||.|    :.:|.|.:   ::.|.|:   |:|
Yeast     7 TFVVDALLVCSSIVDAGVTDFPSLPSNEVYVKMNFQKKYGSSFENALDDTKGRTRLMTRDDDYEL 71

  Fly    51 PSLRSVDEEQLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPS------NTCKSDA----- 104
            ..|         .:.|..|...:.||||.|...||.|:|||:|||..      :|.|.|.
Yeast    72 VEL---------TNQNSFYSVELDIGTPPQKVTVLVDTGSSDLWVTGSDNPYCSTKKKDTTGSSF 127

  Fly   105 ---------------------------------------------CLTHNQYDSSASSTYVANGE 124
                                                         |.|:..:::|.|||:.:|..
Yeast   128 KQVNKDALASVVESVFTEISYDTTIVTSEATATFDSTASTSQLIDCATYGTFNTSKSSTFNSNNT 192

  Fly   125 SFSIQYG-TGSLTGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGM-------AYE 181
            .|||.|| |...:|....|.:.:|.|:|...:||.: ||..:..      |:||:       .|.
Yeast   193 EFSIAYGDTTFASGTWGHDQLSLNDLNITGLSFAVA-NETNSTV------GVLGIGLPGLESTYS 250

  Fly   182 SLAVDGVAPPF-YN-----MVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVP 240
            .:::..|...: ||     :.:.|::.::.:|.: |.|..| ..|.::||..|...|:|.|..:|
Yeast   251 GVSLSSVQKSYTYNNFPMVLKNSGVIKSTAYSLF-ANDSDS-KHGTILFGAVDHGKYAGDLYTIP 313

  Fly   241 I----SEQGY-----WQFTMAGSSIDGYSLCDDCQAIA--------DTGTSLIVAPYNAYITLSE 288
            |    ..:||     :|.|:.|.........|:...:.        |:||::...|......|::
Yeast   314 IINTLQHRGYKDPIQFQVTLQGLGTSKGDKEDNLTTLTTTKIPVLLDSGTTISYMPTELVKMLAD 378

  Fly   289 ILNVGED-----GY--LDC-SSVSSLPDVTFNIGG---TNFVLKPSAYIIQSDGN-CMSAFEYMG 341
              .||..     ||  :|| ..:.....:.|:.||   :|: |.....:..|..| |:.......
Yeast   379 --QVGATYSSAYGYYIMDCIKEMEEESSIIFDFGGFYLSNW-LSDFQLVTDSRSNICILGIAPQS 440

  Fly   342 TDFWILGDVFIGQYYTEFDLGNNRIGFA 369
            ....||||.|:...|..:||.|..|..|
Yeast   441 DPTIILGDNFLANTYVVYDLDNMEISMA 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	97/408 (24%)
Bace	NP_001285756.1	Asp	68..371	CDD:278455	97/401 (24%)
MKC7	NP_010428.3	SAP_like	79..470	CDD:133141	97/402 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1428
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.800