DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bace and YPS1

DIOPT Version :9

Sequence 1:	NP_001285756.1	Gene:	Bace / 34182	FlyBaseID:	FBgn0032049	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_013221.1	Gene:	YPS1 / 850811	SGDID:	S000004110	Length:	569	Species:	Saccharomyces cerevisiae

Alignment Length:	490	Identity:	116/490 - (23%)
Similarity:	193/490 - (39%)	Gaps:	141/490 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KTIAVVVLLAALASAELHR-VPILKEQN------FVK---------TRQNVLAEKSYLRTKYQLP 51
            ||:...||.:..||..|.: :|...:::      |||         :.:||.::|     |.::.
Yeast     4 KTVRSAVLSSLFASQVLGKIIPAANKRDDDSNSKFVKLPFHKLYGDSLENVGSDK-----KPEVR 63

  Fly    52 SLRSVD--EEQLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNT---CKSDA------- 104
            .|:..|  ||.:..:....|...:.:|||.|:..||.|:|||:||:..:.   |.|::
Yeast    64 LLKRADGYEEIIITNQQSFYSVDLEVGTPPQNVTVLVDTGSSDLWIMGSDNPYCSSNSMGSSRRR 128

  Fly   105 ---------------------------------------------------------CLTHNQYD 112
                                                                     |..:..:.
Yeast   129 VIDKRDDSSSGGSLINDINPFGWLTGTGSAIGPTATGLGGGSGTATQSVPASEATMDCQQYGTFS 193

  Fly   113 SSASSTYVANGESFSIQYGTGSL-TGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGIL 176
            :|.|||:.:|...|||.||.|:. :|...||.:|::.|::...:||.: ||..:..      |:|
Yeast   194 TSGSSTFRSNNTYFSISYGDGTFASGTFGTDVLDLSDLNVTGLSFAVA-NETNSTM------GVL 251

  Fly   177 GMAYESLAV---------DGVAPPFYN----MVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSD 228
            |:....|.|         .|.|..:.|    :.:.|.:.::.:|.||  :.:..|.|.::||..|
Yeast   252 GIGLPELEVTYSGSTASHSGKAYKYDNFPIVLKNSGAIKSNTYSLYL--NDSDAMHGTILFGAVD 314

  Fly   229 ASLYSGALTYVPI----SEQGYWQFTMAGSSIDGYSLCDD-----------CQAIADTGTSLIVA 278
            .|.|:|.|..:||    |..|:........:|:|..:.|.           ..|:.|:||:|...
Yeast   315 HSKYTGTLYTIPIVNTLSASGFSSPIQFDVTINGIGISDSGSSNKTLTTTKIPALLDSGTTLTYL 379

  Fly   279 PYNAYITLSEILNV---GEDGY--LDCSSVSSLPDVTFNIGGTNFVLKPSAYIIQSDGNCMSAF- 337
            |......::..|..   ...||  |||.|..|: ::.|:.||.:.....|::|:.:...|:...
Yeast   380 PQTVVSMIATELGAQYSSRIGYYVLDCPSDDSM-EIVFDFGGFHINAPLSSFILSTGTTCLLGII 443

  Fly   338 ---EYMGTDFWILGDVFIGQYYTEFDLGNNRIGFA 369
               :..||   ||||.|:...|..:||.|..|..|
Yeast   444 PTSDDTGT---ILGDSFLTNAYVVYDLENLEISMA 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	97/414 (23%)
Bace	NP_001285756.1	Asp	68..371	CDD:278455	97/407 (24%)
YPS1	NP_013221.1	SAP_like	81..477	CDD:133141	97/408 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.770