Protein Alignment Bace and PGA4

DIOPT Version :9

• Sequence 1: NP_001285756.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_001073276.1
• Gene: PGA4 / 643847
• HGNCID: 8886
• Length: 388
• Species: Homo sapiens
• Alignment Length: 388
• Identity: 169/388 - (43%)
• Similarity: 243/388 - (62%)
• Gaps: 34/388 - (8%)

  Fly    11 LAALASAELHRVPILKEQNFVKTRQNVLAEKSYLR---------------TKYQLPSLRSVDEEQ 60
            |.||:...:::||::::::..:|    |:|:..|:               .:::.|:|  |||:.
Human     9 LVALSECIMYKVPLIRKKSLRRT----LSERGLLKDFLKKHNLNPARKYFPQWEAPTL--VDEQP 67

  Fly    61 LSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKSDACLTHNQYDSSASSTYVANGES 125
            |.|.::|.|:|.|.||||||.|.|:||:|||||||||..|.|.||..||:::...||||.:..|:
Human    68 LENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSET 132

  Fly   126 FSIQYGTGSLTGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESLAVDGVAP 190
            .||.|||||:||.|..|||.|.|:|..:|.|..|..|||:....|.||||||:||.|::..|..|
Human   133 VSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGATP 197

  Fly   191 PFYNMVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQFTMAGSS 255
            .|.|:.:||||...:||.||:.|..|  |..:||||.|:|.|:|:|.:||::.:||||.|:...:
Human   198 VFDNIWNQGLVSQDLFSVYLSADDQS--GSVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSIT 260

  Fly   256 IDGYSL--CDDCQAIADTGTSLIVAPYNAYITLSEILNVGE----DGYLDCSSVSSLPDVTFNIG 314
            ::|.::  .:.||||.||||||:..|.:....:...:...|    |..:.||::|||||:.|.|.
Human   261 MNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTIN 325

  Fly   315 GTNFVLKPSAYIIQSDGNCMSAFEYMGT-----DFWILGDVFIGQYYTEFDLGNNRIGFAPVA 372
            |..:.:.|||||:||:|:|:|.|:.|..     :.||||||||.||:|.||..||::|.||||
Human   326 GVQYPVPPSAYILQSEGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGLAPVA 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	151/320 (47%)
		Asp	68..371	CDD:278455	149/313 (48%)
PGA4	NP_001073276.1	A1_Propeptide	17..45	CDD:311771	6/31 (19%)
		pepsin_A	66..386	CDD:133145	151/321 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151448
Domainoid	1	1.000	297	1.000	Domainoid score	I1463
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I2536
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		mtm8487
orthoMCL	1	0.900	-	-		OOG6_111841
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1456
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.810