Protein Alignment Bace and pgc.2

DIOPT Version :10

• Sequence 1: NP_609235.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_001025603.1
• Gene: pgc.2 / 594991
• XenbaseID: XB-GENE-964422
• Length: 385
• Species: Xenopus tropicalis
• Alignment Length: 389
• Identity: 166/389 - (42%)
• Similarity: 233/389 - (59%)
• Gaps: 30/389 - (7%)

  Fly     7 VVVLLAALASAE-LHRVPILKEQNFVKTRQNVLAEKSYLRTKYQLPSLRSVDEEQLSNS------ 64
            |::....|..:| |.|||:.|.:...:|.:.....|.:::|..:.|:::.  :..|.|.
 Frog     4 VILAFVCLQISEGLIRVPLHKSKTIRETMKEKGVLKEFMKTHKREPAMKY--KYNLKNDFAIAYE 66

  Fly    65 ---MNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKSDACLTHNQYDSSASSTYVANGESF 126
               |:.||||.||:|||.|:|.||||:|||||||.|..|:|.||..|..::.|.||||.:..:.|
 Frog    67 PMYMDAAYYGQISVGTPPQNFMVLFDTGSSNLWVASTYCQSGACQNHPLFNPSQSSTYTSKNQQF 131

  Fly   127 SIQYGTGSLTGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESLAVDGVAPP 191
            ||.||:|||||....|||.|.||||.:|....|.|||||||..::|:||.||||.:||..|...|
 Frog   132 SITYGSGSLTGVFGYDTVTVQGLSITNQEIGLSINEPGTNFVYSSFEGIFGMAYPALAAGGATTP 196

  Fly   192 FYNMVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQFTMAGSSI 256
            ...|:.|.|:...:||.|:     |:..||:||||.|:|||||.:.:.|::::.|||..:...||
 Frog   197 MQGMLQQNLLTYPIFSVYM-----SSQSGEVIFGGVDSSLYSGQIYWAPVTQELYWQIAIDEFSI 256

  Fly   257 DGYSL--CDD-CQAIADTGTSLIVAPYNAYITLSEILNVGEDGY----LDCSSVSSLPDVTFNIG 314
            :|.:.  |.. |||:.||||||:..|.....|..:.|...::.|    ::|::|.|||.::|.|.
 Frog   257 NGQATGWCSQGCQAMVDTGTSLLTVPQQFMGTFLQSLGAQQNQYGEYIVNCNNVQSLPPISFTIN 321

  Fly   315 GTNFVLKPSAYIIQSDGNCMSAFE--YM----GTDFWILGDVFIGQYYTEFDLGNNRIGFAPVA 372
            |..|.:.|||||:|::|.|....|  |:    |..||||||||:.|||:.:|:||||:|||..|
 Frog   322 GVQFPIPPSAYILQNNGYCSVGVEVTYLPSQNGQPFWILGDVFLRQYYSVYDMGNNRVGFAQSA 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_609235.1	pepsin_retropepsin_like	59..369	CDD:472175	151/331 (46%)
pgc.2	NP_001025603.1	A1_Propeptide	19..45	CDD:462326	6/25 (24%)
		pepsin_retropepsin_like	71..382	CDD:472175	148/315 (47%)