DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bace and Cym

DIOPT Version :9

Sequence 1:	NP_001285756.1	Gene:	Bace / 34182	FlyBaseID:	FBgn0032049	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_064476.2	Gene:	Cym / 56825	RGDID:	708486	Length:	379	Species:	Rattus norvegicus

Alignment Length:	385	Identity:	152/385 - (39%)
Similarity:	218/385 - (56%)	Gaps:	36/385 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VVLLAALASAELH---RVPILKEQNFVKTRQNVLAEKSYL-----RTKYQLPSLRS----VDEEQ 60
            |:|||.||.|:.|   |:|:.|.    |:.:|.|.|:..|     |.:|:.....|    |..|.
  Rat     5 VLLLAVLAIAQSHVVTRIPLHKG----KSLRNTLKEQGLLEDFLRRHQYEFSEKNSNIGVVASEP 65

  Fly    61 LSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKSDACLTHNQYDSSASSTYVANGES 125
            |:|.::..|:|.|.:|||.|.|||:||:|||.|||||..|.|..|..||::|.|.|.|:....:.
  Rat    66 LTNYLDSEYFGLIYVGTPPQEFKVVFDTGSSELWVPSVYCSSKVCRNHNRFDPSKSFTFQNLSKP 130

  Fly   126 FSIQYGTGSLTGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESLAVDGVAP 190
            ..:||||||:.|:|:.|||.|:.:.:..||...||.|||..|..:.||||||:||.:.|.....|
  Rat   131 LFVQYGTGSVEGFLAYDTVTVSDIVVPHQTVGLSTEEPGDIFTYSPFDGILGLAYPTFASKYSVP 195

  Fly   191 PFYNMVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQFTMAGSS 255
            .|.||:::.||...:||.|::|:...:|   |..|..|.|.:.|:|.:||::.|||||||
  Rat   196 IFDNMMNRHLVAQDLFSVYMSRNDQGSM---LTLGAIDQSYFIGSLHWVPVTVQGYWQFT----- 252

  Fly   256 IDGYSLCDD-------CQAIADTGTSLIVAPYNAYITLSEILNVGEDGY----LDCSSVSSLPDV 309
            :|..::.|:       |.|:.||||:|:..|....:.:...:...:..:    :||..::.:|.|
  Rat   253 VDRITINDEVVACQGGCPAVLDTGTALLTGPGRDILNIQHAIGAVQGQHDQFDIDCWRLNFMPTV 317

  Fly   310 TFNIGGTNFVLKPSAYIIQSDGNCMSAFEYMGTDFWILGDVFIGQYYTEFDLGNNRIGFA 369
            .|.|.|..|.|.||||..|..|:|.|.|.: |:..||||||||.::|:.||..|||:|.|
  Rat   318 VFEINGREFPLPPSAYTNQFQGSCSSGFRH-GSQMWILGDVFIREFYSVFDRANNRVGLA 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	131/320 (41%)
Bace	NP_001285756.1	Asp	68..371	CDD:278455	129/313 (41%)
Cym	NP_064476.2	A1_Propeptide	19..47	CDD:400357	8/31 (26%)
Cym	NP_064476.2	pepsin_retropepsin_like	64..377	CDD:416259	132/322 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344963
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		otm45782
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860