Protein Alignment Bace and Bace2

DIOPT Version :9

• Sequence 1: NP_001285756.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_062390.3
• Gene: Bace2 / 56175
• MGIID: 1860440
• Length: 514
• Species: Mus musculus
• Alignment Length: 441
• Identity: 118/441 - (26%)
• Similarity: 178/441 - (40%)
• Gaps: 103/441 - (23%)

  Fly     9 VLLAALASAELHRVPILKEQNFVKTRQNVLAEKSYLRTKYQ--------LPSLRSVD-------- 57
            :||..||...|..||.|....|....|...|      |.::        .|.|...|
Mouse     8 LLLPVLAQWLLSAVPALAPAPFTLPLQVARA------TNHRASAVPGLGTPELPRADGLALALEP 66

  Fly    58 ----------EEQLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKSDACLTHN--- 109
                      .:.|.......||..:.||||.|..::|.|:||||..|        |...|:
Mouse    67 VRATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVQILVDTGSSNFAV--------AGAPHSYID 123

  Fly   110 -QYDSSASSTYVANGESFSIQYGTGSLTGYLSTDTVDV-----NGLSIQSQTFAESTN--EPGTN 166
             .:||.:||||.:.|...:::|..||.||::..|.|.:     :...:...|..||.|  .||..
Mouse   124 TYFDSESSSTYHSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESENFFLPGIK 188

  Fly   167 FNDANFDGILGMAYESLA--VDGVAPPFYNMVSQGLVDNSVFSFY-----LARDGTSTMGGELIF 224
            :|     ||||:||.:||  ...:...|.::|:|..:.: :||..     |...|:.|.||.|:.
Mouse   189 WN-----GILGLAYAALAKPSSSLETFFDSLVAQAKIPD-IFSMQMCGAGLPVAGSGTNGGSLVL 247

  Fly   225 GGSDASLYSGALTYVPISEQGYWQFTMAGSSIDGYSLCDDC------QAIADTGTSLIVAPYNAY 283
            ||.:.|||.|.:.|.||.|:.|:|..:....|.|.:|..||      :||.|:||:|:..|...:
Mouse   248 GGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQNLNLDCREYNADKAIVDSGTTLLRLPQKVF 312

  Fly   284 ------ITLSEILNVGEDGY-----LDCSSVSS-----LPDVTFNIGGTN------FVLKPSAYI 326
                  :..:.::....||:     |.|.:.|.     .|.::..:...|      ..:.|..||
Mouse   313 DAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRDENASRSFRITILPQLYI 377

  Fly   327 IQSDGNCMSAFEY--------MGTDFWILGDVFIGQYYTEFDLGNNRIGFA 369
            ....|   :.|.|        ..|:..::|...:..:|..||....|:|||
Mouse   378 QPMMG---AGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQRRVGFA 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	101/363 (28%)
		Asp	68..371	CDD:278455	102/356 (29%)
Bace2	NP_062390.3	beta_secretase_like	85..446	CDD:133140	102/358 (28%)
		Asp	88..425	CDD:278455	100/353 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841605
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740