Protein Alignment Bace and PGC

DIOPT Version :9

• Sequence 1: NP_001285756.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_002621.1
• Gene: PGC / 5225
• HGNCID: 8890
• Length: 388
• Species: Homo sapiens
• Alignment Length: 395
• Identity: 171/395 - (43%)
• Similarity: 245/395 - (62%)
• Gaps: 33/395 - (8%)

  Fly     3 KTIAVVVLLAALASAELHRVPILKEQNFVKT--RQNVLAEKSYLRT-------KYQLPSLRSVDE 58
            |.:.||::...|..|.:.:||:.|.::..:|  .:.:|.|  :|||       ||:...| ||..
Human     2 KWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGE--FLRTHKYDPAWKYRFGDL-SVTY 63

  Fly    59 EQLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKSDACLTHNQYDSSASSTYVANG 123
            |.:: .|:.||:|.||||||.|:|.||||:|||||||||..|:|.||.:|::::.|.||||..||
Human    64 EPMA-YMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFNPSESSTYSTNG 127

  Fly   124 ESFSIQYGTGSLTGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESLAVDGV 188
            ::||:|||:|||||:...||:.|..:.:.:|.|..|.|||||||..|.||||:|:||.:|:||..
Human   128 QTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEA 192

  Fly   189 APPFYNMVSQGLVDNSVFSFYLA-RDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQF--- 249
            ......||.:|.:.:.|||.||: :.|:|  ||.::|||.|:|||:|.:.:.|::::.|||.
Human   193 TTAMQGMVQEGALTSPVFSVYLSNQQGSS--GGAVVFGGVDSSLYTGQIYWAPVTQELYWQIGIE 255

  Fly   250 -TMAGSSIDGYSLCDD-CQAIADTGTSLIVAPYNAYITLSEILNVGEDGY----LDCSSVSSLPD 308
             .:.|....|:  |.: ||||.||||||:..|......|.:.....||.|    ::|:|:.:||.
Human   256 EFLIGGQASGW--CSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQNLPS 318

  Fly   309 VTFNIGGTNFVLKPSAYIIQSDGNCMSAFE--YM----GTDFWILGDVFIGQYYTEFDLGNNRIG 367
            :||.|.|..|.|.||:||:.::|.|....|  |:    |...|||||||:..||:.:||||||:|
Human   319 LTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRSYYSVYDLGNNRVG 383

  Fly   368 FAPVA 372
            ||..|
Human   384 FATAA 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	149/325 (46%)
		Asp	68..371	CDD:278455	149/318 (47%)
PGC	NP_002621.1	A1_Propeptide	18..46	CDD:285240	8/29 (28%)
		gastricsin	70..387	CDD:133144	149/320 (47%)
		Asp	72..387	CDD:278455	149/318 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151471
Domainoid	1	1.000	297	1.000	Domainoid score	I1463
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I2536
Isobase	1	0.950	-	0	Normalized mean entropy	S1195
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		mtm8487
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1428
SonicParanoid	1	1.000	-	-		X1456
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.790