DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bace and ren

DIOPT Version :9

Sequence 1:	NP_001285756.1	Gene:	Bace / 34182	FlyBaseID:	FBgn0032049	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_998025.1	Gene:	ren / 405786	ZFINID:	ZDB-GENE-040630-3	Length:	395	Species:	Danio rerio

Alignment Length:	390	Identity:	161/390 - (41%)
Similarity:	228/390 - (58%)	Gaps:	33/390 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VVVLLAALASAELHRVPI---------LKEQNFVKTRQNVLAEKSYLRTKYQLPS-LRSVDEEQL 61
            :::.|:|:::..|.||.:         |||.:.  |...||:|   :..|||.|| ........|
Zfish     9 LILSLSAISTKALWRVKLKKMPSIRETLKEMSV--TPAQVLSE---IMPKYQEPSPTNGTAPTPL 68

  Fly    62 SNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKS--DACLTHNQYDSSASSTYVANGE 124
            .|.::..|:|.||||:|||.|.|:||:||:||||||::|..  .||.|||:||:|.|.|::.||.
Zfish    69 INYLDTQYFGEISIGSPAQMFNVVFDTGSANLWVPSHSCSPLYTACFTHNRYDASKSLTHIFNGT 133

  Fly   125 SFSIQYGTGSLTGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESLAVDGVA 189
            .|||||.:|::.|:||.|.|.|.|:.: .|.|||:|..|...|..|.|||:|||.|.::|:||:.
Zfish   134 GFSIQYASGNVRGFLSEDVVVVGGIPV-VQVFAEATALPAIPFILAKFDGVLGMGYPNVAIDGIT 197

  Fly   190 PPFYNMVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQFTMAGS 254
            |.|..::||.::..:|||.|.:||.|...||||:.||:|.:.::|...|:...|||.|:..|.|.
Zfish   198 PVFDRIMSQHVLKENVFSVYYSRDPTHIPGGELVLGGTDPNYHTGPFHYINTKEQGKWEVIMKGV 262

  Fly   255 SIDGYSL-C-DDCQAIADTGTSLIVAPYNAYITLSEIL---NVGEDGY-LDCSSVSSLPDVTFNI 313
            |:....| | |.|.|:.|||:|.|..|.::...|.:.:   .:.|.|| :.|:.|..||.|.|::
Zfish   263 SVGADILFCKDGCTAVIDTGSSYITGPASSISILMKTIGAVELAEGGYTVSCNVVRLLPTVAFHL 327

  Fly   314 GGTNFVLKPSAYII-QSDGN---CMSAFEYMGT-----DFWILGDVFIGQYYTEFDLGNNRIGFA 369
            ||..:.|....||: ||:..   |...|:.:..     ..||||..||.:||||||.||||||||
Zfish   328 GGQEYSLTDEDYILWQSEFGEDICTVTFKALDVPPPTGPVWILGANFIARYYTEFDRGNNRIGFA 392

Fly 370 369
Zfish 393 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	142/326 (44%)
Bace	NP_001285756.1	Asp	68..371	CDD:278455	142/319 (45%)
ren	NP_998025.1	A1_Propeptide	23..>38	CDD:285240	3/14 (21%)
		renin_like	68..394	CDD:133154	144/326 (44%)
		Asp	75..394	CDD:278455	142/319 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585921
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.820