Protein Alignment Bace and napsa

DIOPT Version :9

• Sequence 1: NP_001285756.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_956325.1
• Gene: napsa / 336746
• ZFINID: ZDB-GENE-030131-8690
• Length: 412
• Species: Danio rerio
• Alignment Length: 421
• Identity: 167/421 - (39%)
• Similarity: 234/421 - (55%)
• Gaps: 66/421 - (15%)

  Fly     2 FKTIAVVVLLAALASAELHRVPILKEQNFVKTRQNVLAEK----------SYLRTKY-------- 48
            |...|.::.|....|..:.|:|:.|    ::|.:.:||:.          :.::.||
Zfish     4 FHLFAFLIGLLIADSQAIIRIPLHK----MRTVRRMLADNGKTIDEIKSLAKMKAKYSDGTFTNQ 64

  Fly    49 -----------QLPSLRSVDEEQLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCK- 101
                       |||.    ..|:|:|.|:..|||.||||||.|.|.||||:|||||||||..|.
Zfish    65 GSVTIPAPTTTQLPP----PVEKLTNFMDAQYYGMISIGTPPQDFSVLFDTGSSNLWVPSIHCAF 125

  Fly   102 -SDACLTHNQYDSSASSTYVANGESFSIQYGTGSLTGYLSTDTVDVNGLSIQSQTFAESTNEPGT 165
             ..||..|.:|:|..|||||.||..||||||.|||:|::|.|||::.||::..|.|||:..:||.
Zfish   126 LDIACWLHRRYNSKKSSTYVQNGTEFSIQYGRGSLSGFISQDTVNLAGLNVTGQQFAEAVKQPGI 190

  Fly   166 NFNDANFDGILGMAYESLAVDGVAPPFYNMVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSDAS 230
            .|..|.|||:|||||.:::||.|.|.|...::..::..::||||:.||....:||||:.||.|..
Zfish   191 VFAVARFDGVLGMAYPAISVDRVTPVFDTAMAAKILPQNIFSFYINRDPAGDVGGELMLGGFDQQ 255

  Fly   231 LYSGALTYVPISEQGYWQFTM----AGSSIDGYSLC-DDCQAIADTGTSLIVAPYNAYITLSEIL 290
            .::|.|.||.::.:.|||..|    .||::   :|| ..||||.|||||:|..|......|.:.:
Zfish   256 YFNGDLHYVNVTRKAYWQIKMDEVQVGSTL---TLCKSGCQAIVDTGTSMITGPVQEVRALQKAI 317

  Fly   291 N-----VGEDGYLDCSSVSSLPDVTFNIGGTNFVLKPSAYIIQSD----GNCMSAFEYMGTD--- 343
            .     :|| .::||..:.:||.|:|::||..|.|....|:::..    ..|:|.|  |..|
Zfish   318 GAIPLLMGE-YWIDCKKIPTLPVVSFSLGGKMFNLTGQEYVMKMSHMGMNVCLSGF--MAMDIPP 379

  Fly   344 ----FWILGDVFIGQYYTEFDLGNNRIGFAP 370
                .|||||||||:|||.||...:|:||||
Zfish   380 PAGPLWILGDVFIGRYYTVFDRDQDRVGFAP 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	149/332 (45%)
		Asp	68..371	CDD:278455	148/326 (45%)
napsa	NP_956325.1	A1_Propeptide	21..48	CDD:285240	6/30 (20%)
		Cathepsin_D2	86..410	CDD:133157	148/329 (45%)
		Asp	91..411	CDD:278455	148/326 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585933
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.820