DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bace and Pgc

DIOPT Version :9

Sequence 1:	NP_001285756.1	Gene:	Bace / 34182	FlyBaseID:	FBgn0032049	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_579818.1	Gene:	Pgc / 24864	RGDID:	3943	Length:	392	Species:	Rattus norvegicus

Alignment Length:	396	Identity:	171/396 - (43%)
Similarity:	237/396 - (59%)	Gaps:	37/396 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KTIAVVVLLAALASAELHRVPILKEQNFVKT--RQNVLAEKSYLRT-------KYQLPSL--RSV 56
            |.:.|.:|...|..|.|.|||:.|.::..:|  .|.||  |.:|:|       ||...:.  .||
  Rat     2 KWMVVALLCLPLLEASLLRVPLRKMKSIRETMKEQGVL--KDFLKTHKYDPGQKYHFGNFGDYSV 64

  Fly    57 DEEQLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKSDACLTHNQYDSSASSTYVA 121
            ..|.:: .|:.:|:|.||||||.|:|.||||:|||||||.|..|:|:||.||.:::.|.||||..
  Rat    65 LYEPMA-YMDASYFGEISIGTPPQNFLVLFDTGSSNLWVSSVYCQSEACTTHARFNPSKSSTYYT 128

  Fly   122 NGESFSIQYGTGSLTGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESLAVD 186
            .|::||:|||||||||:...||:.|..:.:.:|.|..|.|||||||..|.||||:|:||..|:..
  Rat   129 EGQTFSLQYGTGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPGLSSG 193

  Fly   187 GVAPPFYNMVSQGLVDNSVFSFYL-ARDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQFT 250
            |.......|:.:|.:...:|..|| ::.|::  ||:::|||.|.:||:|.:|:||::::.|||.|
  Rat   194 GATTALQGMLGEGALSQPLFGVYLGSQQGSN--GGQIVFGGVDKNLYTGEITWVPVTQELYWQIT 256

  Fly   251 ----MAGSSIDGYSLCDDCQAIADTGTSLIVAPYNAYITLSEILNV-----GEDG--YLDCSSVS 304
                :.|....|:.....||.|.||||||:|.|..   .|||:|..     ||.|  ::.|.|||
  Rat   257 IDDFLIGDQASGWCSSQGCQGIVDTGTSLLVMPAQ---YLSELLQTIGAQEGEYGEYFVSCDSVS 318

  Fly   305 SLPDVTFNIGGTNFVLKPSAYIIQSDGNCMSAFEYM------GTDFWILGDVFIGQYYTEFDLGN 363
            |||.::|.:.|..|.|.||:||||.|..||...|.:      |...|||||||:..||..||:||
  Rat   319 SLPTLSFVLNGVQFPLSPSSYIIQEDNFCMVGLESISLTSESGQPLWILGDVFLRSYYAIFDMGN 383

  Fly   364 NRIGFA 369
            |::|.|
  Rat   384 NKVGLA 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	149/327 (46%)
Bace	NP_001285756.1	Asp	68..371	CDD:278455	148/320 (46%)
Pgc	NP_579818.1	A1_Propeptide	18..46	CDD:400357	11/29 (38%)
Pgc	NP_579818.1	pepsin_retropepsin_like	73..391	CDD:416259	148/322 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344959
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		otm45782
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1456
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.760