Protein Alignment Bace and BACE1

DIOPT Version :9

• Sequence 1: NP_001285756.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_036236.1
• Gene: BACE1 / 23621
• HGNCID: 933
• Length: 501
• Species: Homo sapiens
• Alignment Length: 389
• Identity: 101/389 - (25%)
• Similarity: 156/389 - (40%)
• Gaps: 82/389 - (21%)

  Fly    49 QLPSLRSVDEE---------------QLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSN 98
            :||  |..|||               .|.......||..:::|:|.|:..:|.|:||||..|.:
Human    42 RLP--RETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGA- 103

  Fly    99 TCKSDACLTHNQYDSSASSTYVANGESFSIQYGTGSLTGYLSTDTVDV-NGLSIQSQTFAESTNE 162
               :.....|..|....||||....:...:.|..|...|.|.||.|.: :|.::..:....:..|
Human   104 ---APHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITE 165

  Fly   163 PGTNF-NDANFDGILGMAYESLA--VDGVAPPFYNMVSQGLVDNSVFSFYLARDG--------TS 216
            ....| |.:|::||||:||..:|  .|.:.|.|.::|.|..|.| :||..|...|        .:
Human   166 SDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPN-LFSLQLCGAGFPLNQSEVLA 229

  Fly   217 TMGGELIFGGSDASLYSGALTYVPISEQGYWQFTMAGSSIDGYSLCDDC------QAIADTGTSL 275
            ::||.:|.||.|.|||:|:|.|.||..:.|::..:....|:|..|..||      ::|.|:||:.
Human   230 SVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTN 294

  Fly   276 IVAPYNAYITLSEILNVGEDGYLDCSSVSSLPD--------VTFNIGGTNF-------------- 318
            :..|       .::...........||....||        |.:..|.|.:
Human   295 LRLP-------KKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEV 352

  Fly   319 -------------VLKPSAYIIQSDGNCMSAFEYMGTDFWILGDVFIGQYYTEFDLGNNRIGFA 369
                         .|:|...:..|..:|........:...::|.|.:..:|..||....|||||
Human   353 TNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	94/377 (25%)
		Asp	68..371	CDD:278455	94/355 (26%)
BACE1	NP_036236.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..58		6/17 (35%)
		beta_secretase_like	72..437	CDD:133140	94/357 (26%)
		Interaction with RTN3	479..501
		DXXLL. /evidence=ECO:0000269|PubMed:15886016	496..500

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151463
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740