Protein Alignment Bace and Ren1

DIOPT Version :9

• Sequence 1: NP_001285756.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_112469.1
• Gene: Ren1 / 19701
• MGIID: 97898
• Length: 402
• Species: Mus musculus
• Alignment Length: 380
• Identity: 152/380 - (40%)
• Similarity: 221/380 - (58%)
• Gaps: 32/380 - (8%)

  Fly    16 SAELHRVPILKEQNFVKTRQNVLAEKSYLRTKY--------QLPSLRSVDEE-QLSNSMNMAYYG 71
            :|...|:|:.|    :.:.:.:|.|:....|:.        :.|||.::... .|:|.:|..|||
Mouse    26 TATFERIPLKK----MPSVREILEERGVDMTRLSAEWGVFTKRPSLTNLTSPVVLTNYLNTQYYG 86

  Fly    72 AISIGTPAQSFKVLFDSGSSNLWVPSNTCKS--DACLTHNQYDSSASSTYVANGESFSIQYGTGS 134
            .|.||||.|:|||:||:||:||||||..|..  .||..|:.|:||.||:|:.||..|:|.||:|.
Mouse    87 EIGIGTPPQTFKVIFDTGSANLWVPSTKCSRLYLACGIHSLYESSDSSSYMENGSDFTIHYGSGR 151

  Fly   135 LTGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESLAVDGVAPPFYNMVSQG 199
            :.|:||.|:|.|.|::: :|||.|.|..|...|..|.|||:|||.:.:.||.||.|.|.:::|||
Mouse   152 VKGFLSQDSVTVGGITV-TQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVGGVTPVFDHILSQG 215

  Fly   200 LVDNSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQFTMAGSSIDGYS-LCD 263
            ::...|||.|..| |:..:|||::.||||...|.|...||.||:...||.||.|.|:...: ||:
Mouse   216 VLKEEVFSVYYNR-GSHLLGGEVVLGGSDPQHYQGNFHYVSISKTDSWQITMKGVSVGSSTLLCE 279

  Fly   264 D-CQAIADTGTSLIVAPYNAYITLSEILNVG----EDGYLDCSSVSSLPDVTFNIGGTNFVLKPS 323
            : |..:.|||:|.|.||.::...:.:.|...    |:..::||.|.:|||::|::||..:.|..:
Mouse   280 EGCAVVVDTGSSFISAPTSSLKLIMQALGAKEKRIEEYVVNCSQVPTLPDISFDLGGRAYTLSST 344

  Fly   324 AYIIQ----SDGNCMSAFEYMGT-----DFWILGDVFIGQYYTEFDLGNNRIGFA 369
            .|::|    .|..|..|...|..     ..|:||..||.::|||||..|||||||
Mouse   345 DYVLQYPNRRDKLCTLALHAMDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFA 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	140/327 (43%)
		Asp	68..371	CDD:278455	139/319 (44%)
Ren1	NP_112469.1	A1_Propeptide	29..54	CDD:285240	6/28 (21%)
		renin_like	76..401	CDD:133154	142/326 (44%)
		Asp	83..401	CDD:278455	139/319 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841577
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.810