DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bace and asp-3

DIOPT Version :9

Sequence 1:	NP_001285756.1	Gene:	Bace / 34182	FlyBaseID:	FBgn0032049	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_509142.2	Gene:	asp-3 / 180947	WormBaseID:	WBGene00000216	Length:	398	Species:	Caenorhabditis elegans

Alignment Length:	396	Identity:	151/396 - (38%)
Similarity:	230/396 - (58%)	Gaps:	39/396 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IAVVVLLAALASAELHRVPILKEQNFVKTRQNVLAEKSYLRTKY---QLPSLRSVDEEQLSNSMN 66
            :.:::.|.||||| :.|:. |:::.:.:.:....:.:.:|:.||   .:|: :....|.||:..|
Worm     5 VFLLLALVALASA-IQRIK-LEKRTYTREQYKFGSIQEHLKAKYVPGYIPN-KDAFNEGLSDYSN 66

  Fly    67 MAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCK--SDACLTHNQYDSSASSTYVANGESFSIQ 129
            ..|||.::||||.|:|:||||:||||||||...|.  ..||..||::|...||:..|.|.||.||
Worm    67 AQYYGPVTIGTPPQNFQVLFDTGSSNLWVPCANCPFGDIACRMHNRFDCKKSSSCTATGASFEIQ 131

  Fly   130 YGTGSLTGYLSTDTV----DVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESLAVDGVAP 190
            |||||:.|.:..|.|    |....:.::|..|.:|:|||..|..|.||||.||.:::::|:.::.
Worm   132 YGTGSMKGTVDNDVVCFGHDTTYCTDKNQGLACATSEPGITFVAAKFDGIFGMGWDTISVNKISQ 196

  Fly   191 PFYNM-VSQGLVDNSVFSFYLARDGTS-TMGGELIFGGSDASLYSGALTYVPISEQGYWQFTMAG 253
            |...: .:..:..|.:|:|:|:||... |.|||:....:|.:.|.|.:.:.|:..:.||:..:|.
Worm   197 PMDQIFANSAICKNQLFAFWLSRDANDITNGGEITLCDTDPNHYVGNIAWEPLVSEDYWRIKLAS 261

  Fly   254 SSIDGYSLCD-DCQAIADTGTSLIVAPYNAYITLSE------ILNVGEDGY-LDCSSVSSLPDVT 310
            ..|||.:... ...:|.||||||:..|.:....:..      :.| ||  | ::||.:.|||::|
Worm   262 VVIDGTTYTSGPIDSIVDTGTSLLTGPTDVIKKIQHKIGGIPLFN-GE--YEVECSKIPSLPNIT 323

  Fly   311 FNIGGTNFVLKPSAYIIQ-SDGN----CMSAFEYMGTD-------FWILGDVFIGQYYTEFDLGN 363
            ||:||.||.|:...||:| |:||    |:|.|  ||.|       .|||||||||::|:.||.||
Worm   324 FNLGGQNFDLQGKDYILQMSNGNGGSTCLSGF--MGMDIPAPAGPLWILGDVFIGRFYSVFDHGN 386

  Fly   364 NRIGFA 369
            .|:|||
Worm   387 KRVGFA 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	137/337 (41%)
Bace	NP_001285756.1	Asp	68..371	CDD:278455	135/330 (41%)
asp-3	NP_509142.2	pepsin_retropepsin_like	59..393	CDD:299705	139/339 (41%)
asp-3	NP_509142.2	Asp	68..393	CDD:278455	135/330 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.890