Protein Alignment Bace and asp-1

DIOPT Version :9

• Sequence 1: NP_001285756.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_741677.1
• Gene: asp-1 / 180251
• WormBaseID: WBGene00000214
• Length: 396
• Species: Caenorhabditis elegans
• Alignment Length: 393
• Identity: 140/393 - (35%)
• Similarity: 209/393 - (53%)
• Gaps: 38/393 - (9%)

  Fly     7 VVVLLAALASAELHRVPILKEQNFVKTRQNVLAEKSYLRTKYQLPSLRSVDEEQLSNS------- 64
            |::.|.|..||.:.:||..|.::.   |..::.|..|  |.: |.|..:...:||:..
 Worm     5 VLLALVAACSAAVIQVPTHKTESL---RAKLIKEGKY--TAF-LASQHAARAQQLNTGFQPFVDY 63

  Fly    65 MNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKSDAC-------LTHNQYDSSASSTYVAN 122
            .:..|.|.|::|||.|...|:.|:|||||||....||:.||       .|..::|::.|:|:|..
 Worm    64 FDDFYLGNITLGTPPQPATVVLDTGSSNLWVIDAACKTQACNGYPDSGYTKQKFDTTKSTTFVKE 128

  Fly   123 GESFSIQYGTGSLTGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESLAVDG 187
            ...||||||:||..|||..|.::..||::|||.|..||:.... |.....|||||:.:.:||||.
 Worm   129 TRKFSIQYGSGSCNGYLGKDVLNFGGLTVQSQEFGVSTHLADV-FGYQPVDGILGLGWPALAVDQ 192

  Fly   188 VAPPFYNMVSQGLVDNSVFSFYLARD---GTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQF 249
            |.||..|:::|..:|..:|:.:|.|:   ...|.||.:.:|..|....:..:||||:|.:.||||
 Worm   193 VVPPMQNLIAQKQLDAPLFTVWLDRNLQIAQGTPGGLITYGAIDTVNCAKQVTYVPLSAKTYWQF 257

  Fly   250 TMAGSSIDGYSLCDDCQAIADTGTSLIVAPYNAYIT-----LSEILNVGEDGY-LDCSSVSSLPD 308
            .:...::..||.....|.|:|||||.:.|| |..::     ...:.:...:.| :|||::.:.||
 Worm   258 PLDAFAVGTYSETKKDQVISDTGTSWLGAP-NTIVSAIVKQTKAVFDWSTELYTVDCSTMKTQPD 321

  Fly   309 VTFNIGGTNFVLKPSAYIIQ---SDGNCMSAFEYMGT----DFWILGDVFIGQYYTEFDLGNNRI 366
            :.|.|||..|.:|...|::.   ..|.|..|...||:    ..|||||.||.||...:|:||.:|
 Worm   322 LIFTIGGAQFPVKSVEYVLDLQLGGGKCALAVFSMGSGGFGPSWILGDTFIRQYCNVYDIGNGQI 386

  Fly   367 GFA 369
            |||
 Worm   387 GFA 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	124/339 (37%)
		Asp	68..371	CDD:278455	124/325 (38%)
asp-1	NP_741677.1	A1_Propeptide	17..45	CDD:369623	8/33 (24%)
		Asp	67..391	CDD:365818	124/325 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161974
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1428
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.890