DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bace and Ctsd

DIOPT Version :9

Sequence 1:	NP_001285756.1	Gene:	Bace / 34182	FlyBaseID:	FBgn0032049	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_599161.2	Gene:	Ctsd / 171293	RGDID:	621511	Length:	407	Species:	Rattus norvegicus

Alignment Length:	404	Identity:	179/404 - (44%)
Similarity:	237/404 - (58%)	Gaps:	42/404 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IAVVVLLAALASAELHRVPILKEQNFVKTRQNV--LAEKSYLR---TKYQL---PSLRSVDEEQL 61
            :.::.||||.:|| |.|:|:.|..:..:|...|  ..|...|:   |||.:   |..:....|.|
  Rat     8 LLILGLLAASSSA-LIRIPLRKFTSIRRTMTEVGGSVEDLILKGPITKYSMQSSPRTKEPVSELL 71

  Fly    62 SNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCK--SDACLTHNQYDSSASSTYVANGE 124
            .|.::..|||.|.||||.|.|.|:||:|||||||||..||  ..||..|::|:|..|||||.||.
  Rat    72 KNYLDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWVHHKYNSDKSSTYVKNGT 136

  Fly   125 SFSIQYGTGSLTGYLSTDTV------DVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESL 183
            ||.|.||:|||:||||.|||      |:.|:.::.|.|.|:|.:||..|..|.|||||||.|..:
  Rat   137 SFDIHYGSGSLSGYLSQDTVSVPCKSDLGGIKVEKQIFGEATKQPGVVFIAAKFDGILGMGYPFI 201

  Fly   184 AVDGVAPPFYNMVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQ 248
            :|:.|.|.|.|::.|.||:.::|||||.||.|...||||:.||:|:..|.|.|:|:.::.:.|||
  Rat   202 SVNNVLPVFDNLMKQKLVEKNIFSFYLNRDPTGQPGGELMLGGTDSRYYHGELSYLNVTRKAYWQ 266

  Fly   249 FTM----AGSSIDGYSLC-DDCQAIADTGTSLIVAPYNAYITLSEILN----VGEDGYLDCSSVS 304
            ..|    .||.:   :|| ..|:||.||||||:|.|.:....|.:.:.    :..:..:.|..||
  Rat   267 VHMDQLEVGSEL---TLCKGGCEAIVDTGTSLLVGPVDEVKELQKAIGAVPLIQGEYMIPCEKVS 328

  Fly   305 SLPDVTFNIGGTNFVLKPSAYI--IQSDGN--CMSAFEYMGTD-------FWILGDVFIGQYYTE 358
            |||.:||.:||.|:.|.|..||  :...|.  |:|.|  ||.|       .|||||||||.|||.
  Rat   329 SLPIITFKLGGQNYELHPEKYILKVSQAGKTICLSGF--MGMDIPPPSGPLWILGDVFIGCYYTV 391

  Fly   359 FDLGNNRIGFAPVA 372
            ||...||:|||..|
  Rat   392 FDREYNRVGFAKAA 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	158/337 (47%)
Bace	NP_001285756.1	Asp	68..371	CDD:278455	157/330 (48%)
Ctsd	NP_599161.2	A1_Propeptide	21..46	CDD:285240	7/24 (29%)
		Cathepsin_D2	73..403	CDD:133157	157/334 (47%)
		Asp	78..404	CDD:278455	157/330 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930