Protein Alignment Bace and Ctse

DIOPT Version :9

• Sequence 1: NP_001285756.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_031825.2
• Gene: Ctse / 13034
• MGIID: 107361
• Length: 397
• Species: Mus musculus
• Alignment Length: 401
• Identity: 174/401 - (43%)
• Similarity: 229/401 - (57%)
• Gaps: 47/401 - (11%)

  Fly     5 IAVVVLLAALASAE--LHRVPILKEQNFVKTRQNVLAEKSYLRTKYQLPSL---RSVDEEQLSNS 64
            :.:::||..||.|:  |||||:.:.|:..|.          ||.:.||...   .::|..:||.|
Mouse     6 VLLLLLLLDLAQAQGALHRVPLRRHQSLRKK----------LRAQGQLSEFWRSHNLDMTRLSES 60

  Fly    65 MN--------------MAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKSDACLTHNQYDSSA 115
            .|              |.|:|.||||||.|:|.|:||:|||||||||..|.|.||..|..:..|.
Mouse    61 CNVYSSVNEPLINYLDMEYFGTISIGTPPQNFTVIFDTGSSNLWVPSVYCTSPACKAHPVFHPSQ 125

  Fly   116 SSTYVANGESFSIQYGTGSLTGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAY 180
            |.||...|..||||||||||||.:..|.|.|.||::..|.|.||..|||..|.:|.||||||:.|
Mouse   126 SDTYTEVGNHFSIQYGTGSLTGIIGADQVSVEGLTVDGQQFGESVKEPGQTFVNAEFDGILGLGY 190

  Fly   181 ESLAVDGVAPPFYNMVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVPISEQG 245
            .|||..||.|.|.||::|.||...:||.||:.|.....|.||.|||.|.|.:||:|.::|:::|.
Mouse   191 PSLAAGGVTPVFDNMMAQNLVALPMFSVYLSSDPQGGSGSELTFGGYDPSHFSGSLNWIPVTKQA 255

  Fly   246 YWQFTMAGSSI-DGYSLCDD-CQAIADTGTSLIVAPYNAYITLSEILNVGE-DG--YLDCSSVSS 305
            |||..:.|..: |....|.: ||||.|||||||..|.:....|.|.:.... ||  .:||:::.:
Mouse   256 YWQIALDGIQVGDTVMFCSEGCQAIVDTGTSLITGPPDKIKQLQEAIGATPIDGEYAVDCATLDT 320

  Fly   306 LPDVTFNIGGTNFVLKPSAYIIQS--DGN--CMSAFEYMGTD-------FWILGDVFIGQYYTEF 359
            :|:|||.|...::.|.|:.||:..  :|.  |.|.|:  |.|       .||||||||.|:|:.|
Mouse   321 MPNVTFLINEVSYTLNPTDYILPDLVEGMQFCGSGFQ--GLDIPPPAGPLWILGDVFIRQFYSVF 383

  Fly   360 DLGNNRIGFAP 370
            |.|||::|.||
Mouse   384 DRGNNQVGLAP 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	155/339 (46%)
		Asp	68..371	CDD:278455	152/319 (48%)
Ctse	NP_031825.2	A1_Propeptide	22..50	CDD:285240	11/37 (30%)
		Asp	78..395	CDD:278455	152/319 (48%)
		pepsin_retropepsin_like	79..394	CDD:299705	150/316 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841585
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	307	1.000	Inparanoid score	I2599
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		otm43705
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.910