Protein Alignment Bace and Ctsd

DIOPT Version :10

• Sequence 1: NP_609235.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_034113.1
• Gene: Ctsd / 13033
• MGIID: 88562
• Length: 410
• Species: Mus musculus
• Alignment Length: 409
• Identity: 179/409 - (43%)
• Similarity: 234/409 - (57%)
• Gaps: 47/409 - (11%)

  Fly     3 KTIAVVVL---LAALASAELHRVPILKEQNFVKTRQNV--LAEKSYLR---TKYQLPSLRSVDE- 58
            ||..|::|   |.|.:|..:.|:|:.|..:..:|...|  ..|...|:   |||.:.|.....|
Mouse     2 KTPGVLLLILGLLASSSFAIIRIPLRKFTSIRRTMTEVGGSVEDLILKGPITKYSMQSSPKTTEP 66

  Fly    59 --EQLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCK--SDACLTHNQYDSSASSTY 119
              |.|.|.::..|||.|.||||.|.|.|:||:|||||||||..||  ..||..|::|:|..||||
Mouse    67 VSELLKNYLDAQYYGDIGIGTPPQCFTVVFDTGSSNLWVPSIHCKILDIACWVHHKYNSDKSSTY 131

  Fly   120 VANGESFSIQYGTGSLTGYLSTDTVDV---------NGLSIQSQTFAESTNEPGTNFNDANFDGI 175
            |.||.||.|.||:|||:||||.|||.|         .|:.::.|.|.|:|.:||..|..|.||||
Mouse   132 VKNGTSFDIHYGSGSLSGYLSQDTVSVPCKSDQSKARGIKVEKQIFGEATKQPGIVFVAAKFDGI 196

  Fly   176 LGMAYESLAVDGVAPPFYNMVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVP 240
            |||.|..::|:.|.|.|.|::.|.|||.::|||||.||.....||||:.||:|:..|.|.|:|:.
Mouse   197 LGMGYPHISVNNVLPVFDNLMQQKLVDKNIFSFYLNRDPEGQPGGELMLGGTDSKYYHGELSYLN 261

  Fly   241 ISEQGYWQFTM----AGSSIDGYSLC-DDCQAIADTGTSLIVAPYNAYITLSEILN----VGEDG 296
            ::.:.|||..|    .|:.:   :|| ..|:||.||||||:|.|......|.:.:.    :..:.
Mouse   262 VTRKAYWQVHMDQLEVGNEL---TLCKGGCEAIVDTGTSLLVGPVEEVKELQKAIGAVPLIQGEY 323

  Fly   297 YLDCSSVSSLPDVTFNIGGTNFVLKPSAYIIQ-SDGN---CMSAFEYMGTD-------FWILGDV 350
            .:.|..|||||.|...:||.|:.|.|..||:: |.|.   |:|.|  ||.|       .||||||
Mouse   324 MIPCEKVSSLPTVYLKLGGKNYELHPDKYILKVSQGGKTICLSGF--MGMDIPPPSGPLWILGDV 386

  Fly   351 FIGQYYTEFDLGNNRIGFA 369
            |||.|||.||..|||:|||
Mouse   387 FIGSYYTVFDRDNNRVGFA 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_609235.1	pepsin_retropepsin_like	59..369	CDD:472175	158/340 (46%)
Ctsd	NP_034113.1	A1_Propeptide	23..49	CDD:462326	6/25 (24%)
		Cathepsin_D2	73..405	CDD:133157	156/336 (46%)