DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bace and nots

DIOPT Version :9

Sequence 1:	NP_001285756.1	Gene:	Bace / 34182	FlyBaseID:	FBgn0032049	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_571879.1	Gene:	nots / 114367	ZFINID:	ZDB-GENE-010620-1	Length:	416	Species:	Danio rerio

Alignment Length:	378	Identity:	142/378 - (37%)
Similarity:	210/378 - (55%)	Gaps:	34/378 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ASAELHRVPILKEQNFVKTRQNVLAEKSYLR----TKYQLPSLRSVDEEQLSNSMNMAYYGAISI 75
            |||:|        :.|:|..|..:..:.|::    .::.|...|.| .|:|.|.|:..::|.||:
Zfish    37 ASAQL--------EEFLKQHQPDMFSRRYVQCFPPAQHFLRPGRRV-TERLYNFMDAQFFGQISL 92

  Fly    76 GTPAQSFKVLFDSGSSNLWVPSNTCKSDACLTHNQYDSSASSTYVANGESFSIQYGTGSLTGYLS 140
            |.|.|:|.|:||:|||:|||||:.|.:.||..||::.:..||||..:|..|.|.||:|.|.|.::
Zfish    93 GRPEQNFTVVFDTGSSDLWVPSSYCVTQACALHNKFKAFESSTYTHDGRVFGIHYGSGHLLGVMA 157

  Fly   141 TDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESLAVDGVAPPFYNMVSQGLVDNSV 205
            .|.:.|..:.:|:|.|.|:..|||.:|..|.|||:||:.:..||.:..:|.|..|:.|.::|..|
Zfish   158 RDELKVGSVRVQNQVFGEAVYEPGFSFVLAQFDGVLGLGFPQLAEEKGSPVFDTMMEQNMLDQPV 222

  Fly   206 FSFYLARDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQFTMAGSSIDGYSLCDD-----C 265
            |||||..:| |..||||:||.:|.|.:...:.::|::::||||..:....:.|.....|     |
Zfish   223 FSFYLTNNG-SGFGGELVFGANDESRFLPPINWIPVTQKGYWQIKLDAVKVQGALSFSDRSVQGC 286

  Fly   266 QAIADTGTSLIVAPYNAYITLSEILNV-----GEDGYLDCSSVSSLPDVTFNIGGTNFVLKPSAY 325
            |||.|||||||..|....:.|.:.:..     || ..:||..|||||.|:|.|....:.|....|
Zfish   287 QAIVDTGTSLIGGPARDILILQQFIGATPTANGE-FVVDCVRVSSLPVVSFLINSVEYSLSGEQY 350

  Fly   326 IIQSDGN----CMSAFEYM-----GTDFWILGDVFIGQYYTEFDLGNNRIGFA 369
            :.:...|    |.|.|:.:     ....|||||||:.|.|:.:|.|.||:|.|
Zfish   351 VRRETLNNKQICFSGFQSIEVPSPAGPVWILGDVFLSQVYSIYDRGENRVGLA 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	130/328 (40%)
Bace	NP_001285756.1	Asp	68..371	CDD:278455	127/321 (40%)
nots	NP_571879.1	A1_Propeptide	20..48	CDD:285240	6/18 (33%)
		Asp	85..403	CDD:278455	126/319 (39%)
		pepsin_retropepsin_like	86..403	CDD:299705	126/318 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585925
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.960