DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bace and Pgc

DIOPT Version :9

Sequence 1:	NP_001285756.1	Gene:	Bace / 34182	FlyBaseID:	FBgn0032049	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_080249.2	Gene:	Pgc / 109820	MGIID:	98909	Length:	392	Species:	Mus musculus

Alignment Length:	397	Identity:	173/397 - (43%)
Similarity:	239/397 - (60%)	Gaps:	37/397 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KTIAVVVLLAALASAELHRVPILKEQNFVKT--RQNVLAEKSYLRTKYQLPSLR---------SV 56
            |.:.|.:|...|..|.|.|||:.|.::..:|  .|.||  |.:|:.....|..:         ||
Mouse     2 KWMVVALLCLPLLEAALIRVPLKKMKSIRETMKEQGVL--KDFLKNHKYDPGQKYHFGKFGDYSV 64

  Fly    57 DEEQLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKSDACLTHNQYDSSASSTYVA 121
            ..|.:: .|:.:|||.||||||.|:|.||||:|||||||.|..|:|:||.||.:|:.|.||||..
Mouse    65 LYEPMA-YMDASYYGEISIGTPPQNFLVLFDTGSSNLWVSSVYCQSEACTTHTRYNPSKSSTYYT 128

  Fly   122 NGESFSIQYGTGSLTGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESLAVD 186
            .|::||:|||||||||:...||:.|..:.:.:|.|..|.|||||||..|.||||:|:||..|:..
Mouse   129 QGQTFSLQYGTGSLTGFFGYDTLRVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPGLSSG 193

  Fly   187 GVAPPFYNMVSQGLVDNSVFSFYL-ARDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQFT 250
            |.......|:.:|.:...:|..|| ::.|::  ||:::|||.|.:||:|.||::|::::.|||.|
Mouse   194 GATTALQGMLGEGALSQPLFGVYLGSQQGSN--GGQIVFGGVDENLYTGELTWIPVTQELYWQIT 256

  Fly   251 ----MAGSSIDGYSLCDDCQAIADTGTSLIVAPYNAYITLSEILNV-----GEDG--YLDCSSVS 304
                :.|:...|:.....||.|.||||||:|.|..   .|:|:|..     ||.|  ::.|.|||
Mouse   257 IDDFLIGNQASGWCSSSGCQGIVDTGTSLLVMPAQ---YLNELLQTIGAQEGEYGQYFVSCDSVS 318

  Fly   305 SLPDVTFNIGGTNFVLKPSAYIIQSDGNCMSAFEYM------GTDFWILGDVFIGQYYTEFDLGN 363
            |||.:||.:.|..|.|.||:||||.:|:||...|.:      |...|||||||:..||..||:||
Mouse   319 SLPTLTFVLNGVQFPLSPSSYIIQEEGSCMVGLESLSLNAESGQPLWILGDVFLRSYYAVFDMGN 383

  Fly   364 NRIGFAP 370
            ||:|.||
Mouse   384 NRVGLAP 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	152/327 (46%)
Bace	NP_001285756.1	Asp	68..371	CDD:278455	152/321 (47%)
Pgc	NP_080249.2	A1_Propeptide	18..46	CDD:285240	11/29 (38%)
		pepsin_retropepsin_like	73..391	CDD:299705	152/323 (47%)
		Asp	75..390	CDD:278455	150/319 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841597
Domainoid	1	1.000	297	1.000	Domainoid score	I1457
eggNOG	1	0.900	-	-		E1_KOG1339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	307	1.000	Inparanoid score	I2599
Isobase	1	0.950	-	0	Normalized mean entropy	S1195
OMA	1	1.010	-	-		QHG54317
OrthoDB	1	1.010	-	-		D1619495at2759
OrthoFinder	1	1.000	-	-		FOG0000066
OrthoInspector	1	1.000	-	-		otm43705
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1428
SonicParanoid	1	1.000	-	-		X1456
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.790