Protein Alignment Bace and bace2

DIOPT Version :9

• Sequence 1: NP_001285756.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_001135590.1
• Gene: bace2 / 100216145
• XenbaseID: XB-GENE-1014090
• Length: 499
• Species: Xenopus tropicalis
• Alignment Length: 437
• Identity: 119/437 - (27%)
• Similarity: 173/437 - (39%)
• Gaps: 102/437 - (23%)

  Fly     5 IAVVVLLAALASAELHRVPILKEQNFVKTRQNVLAEKSYL-----RTKYQLPSLRSVDE------ 58
            :||::|.||.|||           ||:...:...||....     .|....|.|....:
 Frog     6 LAVLLLGAACASA-----------NFIFPLKVSPAEMKGAVPVAPATPKGAPGLLLASDPGGQIN 59

  Fly    59 -----EQLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWV-----PSNTCKSDACLTHNQYDS 113
                 ..|.......||..:.||||.|...:|.|:||||..|     |..|         ..:||
 Frog    60 FFSMVNNLEGDSGRGYYLELLIGTPPQKMNILVDTGSSNFAVAGALNPDIT---------TFFDS 115

  Fly   114 SASSTYVANGESFSIQYGTGSLTGYLSTDTVD----VNGLSI-------QSQTFAESTNEPGTNF 167
            ..|::|.......:::|..||.||.|..|.:.    |||..:       ||:.|.         .
 Frog   116 KLSTSYEPLNTQVTVRYTQGSWTGLLGKDVISMPKGVNGTFLINIASIFQSENFF---------L 171

  Fly   168 NDANFDGILGMAYESLA--VDGVAPPFYNMVSQGLVDNSVFSFYLARDGTSTMG-----GELIFG 225
            .:.|:.||||:||.:||  ...|.|.|.::|.|..:.| :||..:...|..:.|     |.|:.|
 Frog   172 PNINWQGILGLAYSTLAKPSSSVEPFFDSLVQQENIPN-IFSMQMCGAGQPSPGIGINAGSLVLG 235

  Fly   226 GSDASLYSGALTYVPISEQGYWQFTMAGSSIDGYSLCDDC------QAIADTGTSLIVAP----- 279
            |.:.|||.|.:.|.||:|:.|:|..:....:.|.:|..||      :||.|:||:|:..|
 Frog   236 GIEPSLYQGDIWYTPITEEWYYQVEVLKFEVGGQNLNLDCTVYNSDKAIVDSGTTLLRLPDKVFN 300

  Fly   280 --YNAYITLSEILNVGEDGY----LDCSSVSS-----LPDVTFNIGGTN------FVLKPSAYI- 326
              .:|.:..|.|.|...:.:    |.|...:.     .||::..:..||      ..|||..||
 Frog   301 AMVDAIVQTSLIQNFNAEFWAGLQLACWDKTQDPWNYFPDISIYLRDTNSSRSFRLTLKPQLYIQ 365

  Fly   327 ----IQSDGNCMSAFEYMGTDFWILGDVFIGQYYTEFDLGNNRIGFA 369
                .|...||............::|...:..:|..||....|:|||
 Frog   366 SVLTFQESLNCFRFGISQSASALVIGATVMEGFYVIFDRAEKRVGFA 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_001285756.1	pepsin_retropepsin_like	59..369	CDD:299705	102/365 (28%)
		Asp	68..371	CDD:278455	103/358 (29%)
bace2	NP_001135590.1	beta_secretase_like	72..433	CDD:133140	103/360 (29%)
		Asp	75..412	CDD:278455	101/355 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910