Protein Alignment Bace and ctse

DIOPT Version :10

• Sequence 1: NP_609235.1
• Gene: Bace / 34182
• FlyBaseID: FBgn0032049
• Length: 372
• Species: Drosophila melanogaster
• Sequence 2: NP_001120469.1
• Gene: ctse / 100145572
• XenbaseID: XB-GENE-947864
• Length: 397
• Species: Xenopus tropicalis
• Alignment Length: 390
• Identity: 178/390 - (45%)
• Similarity: 240/390 - (61%)
• Gaps: 25/390 - (6%)

  Fly     3 KTIAVVVLLAALASAELHRVPILKEQNFVKTRQNVLAEKSYLRTKYQLPSLRSVD--------EE 59
            :.|.:::|.|.|... |.||| ||.|..::.:.....:.|::.|:..:..::..|        .|
 Frog     2 RQILLLLLFATLVYG-LIRVP-LKRQKSIRKKLKEKGKLSHVWTQQGIDMIQYTDSCSNNQAPSE 64

  Fly    60 QLSNSMNMAYYGAISIGTPAQSFKVLFDSGSSNLWVPSNTCKSDACLTHNQYDSSASSTYVANGE 124
            .|.|.|::.|:|.||||||.|:|.|:||:|||||||||..|.|.||..||::....||||.:||.
 Frog    65 PLINYMDVEYFGEISIGTPPQNFTVIFDTGSSNLWVPSVYCISPACAQHNRFQPQFSSTYQSNGN 129

  Fly   125 SFSIQYGTGSLTGYLSTDTVDVNGLSIQSQTFAESTNEPGTNFNDANFDGILGMAYESLAVDGVA 189
            :||:|||||||:|.:.||:|.|.|:.:|||.|.||.:|||:.|.||.||||||:.|.|:||....
 Frog   130 NFSLQYGTGSLSGIIGTDSVSVEGILVQSQQFGESVSEPGSTFVDAEFDGILGLGYPSIAVGDCT 194

  Fly   190 PPFYNMVSQGLVDNSVFSFYLARDGTSTMGGELIFGGSDASLYSGALTYVPISEQGYWQFTMAGS 254
            |.|.||::|.||:..:||.|::|:..|.:||||:|||.|||.:||.|.:|.::.|||||..:...
 Frog   195 PVFDNMMTQNLVELPMFSVYMSRNPNSPVGGELVFGGFDASRFSGQLNWVSVTNQGYWQIQLDNI 259

  Fly   255 SIDG-YSLC-DDCQAIADTGTSLIVAPYNAYITLSEILNVGE---DGYLDCSSVSSLPDVTFNIG 314
            .|:| ...| ..||||.|||||||..|.:..:.|..|:....   |..:|||.::.:|.|||.|.
 Frog   260 QINGEVVFCTGGCQAIVDTGTSLITGPSSDIVQLQSIIGASAANGDYEVDCSVLNEMPTVTFTIN 324

  Fly   315 GTNFVLKPSAYIIQSDGN-CMSAFEYMGTD-------FWILGDVFIGQYYTEFDLGNNRIGFAPV 371
            |..:.:.|..|.:|..|. |.|.|:  |.|       .||||||||||||:.||.||||:|.|||
 Frog   325 GIGYQMTPQQYTLQDGGGICSSGFQ--GLDISPPAGPLWILGDVFIGQYYSVFDRGNNRVGLAPV 387

  Fly   372  371
             Frog   388  387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bace	NP_609235.1	pepsin_retropepsin_like	59..369	CDD:472175	161/322 (50%)
ctse	NP_001120469.1	A1_Propeptide	19..45	CDD:462326	8/26 (31%)
		pepsin_retropepsin_like	74..386	CDD:472175	157/313 (50%)