Protein Alignment IDH2 and IDP1

DIOPT Version :10

• Sequence 1: NP_002159.2
• Gene: IDH2 / 3418
• HGNCID: 5383
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_010217.1
• Gene: IDP1 / 851493
• SGDID: S000002224
• Length: 428
• Species: Saccharomyces cerevisiae
• Alignment Length: 416
• Identity: 259/416 - (62%)
• Similarity: 317/416 - (76%)
• Gaps: 13/416 - (3%)

Human    40 ADKRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALAT 104
            |..:|||.:||||:||||||||||..||:|||||::|:.|||:||.:.:||.|.|::|.|:|.|.
Yeast    16 AFSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDAAEAI 80

Human   105 QKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPIT 169
            :||.|.:||||||||||||:||.|.|||||||||||||||||||||||:...||||||.|.|||.
Yeast    81 KKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRLVPRWEKPII 145

Human   170 IGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGV--KEWEVYNFPAGGVGMGMYNTDESISGFA 232
            ||||||||||||||.:....|:.::|:.|.|.:..  :..:||::...||.|.||||||||.|||
Yeast   146 IGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFA 210

Human   233 HSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQV 297
            ||.|:.||.||..|::||||||||.|||||||||||:::..||:.|::..|.||||||||||||:
Yeast   211 HSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQM 275

Human   298 LKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGR 362
            :||.|||:.|.|||||||||||:||||||||||||:||.|||||.|:||||||||||||::|||.
Yeast   276 IKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGE 340

Human   363 PTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETV-ESGAMTKDLA-GCIHGLSNV 425
            .||||.|||||||:|||..||:||....|.:||.:||...:.|| :.|.|||||| .|.:
Yeast   341 ETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGN----- 400

Human   426 KLNEH--FLNTTDFLDTIKSNLDRAL 449
              ||.  ::.|.:|||.::..|.:.:
Yeast   401 --NERSAYVTTEEFLDAVEKRLQKEI 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IDH2	NP_002159.2	PTZ00435	39..451	CDD:240417	259/416 (62%)
IDP1	NP_010217.1	PRK08299	18..424	CDD:236226	258/412 (63%)