Protein Alignment IDH2 and idh2

DIOPT Version :10

• Sequence 1: NP_002159.2
• Gene: IDH2 / 3418
• HGNCID: 5383
• Length: 452
• Species: Homo sapiens
• Sequence 2: NP_955858.1
• Gene: idh2 / 386951
• ZFINID: ZDB-GENE-031118-95
• Length: 449
• Species: Danio rerio
• Alignment Length: 451
• Identity: 381/451 - (84%)
• Similarity: 416/451 - (92%)
• Gaps: 2/451 - (0%)

Human     1 MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTRIIWQF 65
            |||||:|:.||.| |.:..:.:||.| ||..|...:|:||||||:||:|||||||||||||||:|
Zfish     1 MAGYLKVLSSLSR-SAATLSKSPAVL-APACQSLQQRNYADKRIQVAQPVVEMDGDEMTRIIWEF 63

Human    66 IKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKK 130
            |||||||.:|::.|||:|||||.|||||||||||||:||:||:||||||||||||||||||||||
Zfish    64 IKEKLILTNVNVDLKYYDLGLPYRDQTDDQVTIDSAIATKKYNVAVKCATITPDEARVEEFKLKK 128

Human   131 MWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMV 195
            |||||||||||||||||||||||||||||||||||:.|||||||.||||||||||.::.|.||||
Zfish   129 MWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTQAITIGRHAFGDQYKATDFVVNQPGKFKMV 193

Human   196 FTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDG 260
            |||.|||..||||||:||.||.|||||||||||:|||||||||||||||||||||||||||||||
Zfish   194 FTPADGSKNKEWEVYDFPGGGCGMGMYNTDESITGFAHSCFQYAIQKKWPLYMSTKNTILKAYDG 258

Human   261 RFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFG 325
            |||||||:||:|:||.:|||.|||||||||||||||||||||.||||||||||||||||||||||
Zfish   259 RFKDIFQDIFEKNYKPEFDKLKIWYEHRLIDDMVAQVLKSSGAFVWACKNYDGDVQSDILAQGFG 323

Human   326 SLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQD 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|
Zfish   324 SLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNPD 388

Human   391 LIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRALGR 451
            ||:|:|.||:|||||||||.||||||||||||:|.|||||::|||||||.||:|||:|||:
Zfish   389 LIKFSQTLERVCVETVESGVMTKDLAGCIHGLANCKLNEHYVNTTDFLDAIKTNLDKALGK 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IDH2	NP_002159.2	PTZ00435	39..451	CDD:240417	363/411 (88%)
idh2	NP_955858.1	PTZ00435	37..449	CDD:240417	363/411 (88%)