DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment d and MYO2

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_014971.1	Gene:	MYO2 / 854504	SGDID:	S000005853	Length:	1574	Species:	Saccharomyces cerevisiae

Alignment Length:	797	Identity:	223/797 - (27%)
Similarity:	365/797 - (45%)	Gaps:	98/797 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   476 QDLIHLSGPLTEHAVMRTLQARFNERRYFTNVGPILLSINPYLDVGNPLT------LTSTRAMPL 534
            :||..|| .|.|.||:..::.|:::...:|..|.:|::.||:..|....|      ....|...|
Yeast    73 EDLTSLS-YLNEPAVLHAIKQRYSQLNIYTYSGIVLIATNPFDRVDQLYTQDMIQAYAGKRRGEL 136

  Fly   535 APQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGGGPET--------DA 591
            .|.|..|.:||.|........|.|::||.||||||.:|..::|...::......|        :.
Yeast   137 EPHLFAIAEEAYRLMKNDKQNQTIVVSGESGAGKTVSAKYIMRYFASVEEENSATVQHQVEMSET 201

  Fly   592 FKHLAAAFTVLRSLGSAKTTTNSESSRIGQFIEVQV-TDGALYRTKIHCYFLDQTRVIRPLPKEK 655
            .:.:.|...::.:.|:||||.|..|||.|:::|:.. .|.::...:|..|.|:::|::...|.|:
Yeast   202 EQKILATNPIMEAFGNAKTTRNDNSSRFGKYLEILFDKDTSIIGARIRTYLLERSRLVYQPPIER 266

  Fly   656 NYHIFYQLLAGLSREERQKLHLDGYSPANLRYLRGDIGQNEQEDAARFQAWKTCLGILGI---PF 717
            ||||||||:|||..:.:::|||...|........||...|..:||..::.....|.::||   ..
Yeast   267 NYHIFYQLMAGLPAQTKEELHLTDASDYFYMNQGGDTKINGIDDAKEYKITVDALTLVGITKETQ 331

  Fly   718 LDVVRVLAAVLLLGNVQF---IDGGGLEVDVKGETELNSVASLLGVPPAALFRGLTTRTHNVRGQ 779
            ..:.::|||:|.:||::.   .:...|..|   |..|.....|||:......:.:|.:....|.:
Yeast   332 HQIFKILAALLHIGNIEIKKTRNDASLSAD---EPNLKLACELLGIDAYNFAKWVTKKQIITRSE 393

  Fly   780 LVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHNQADVASQH 844
            .:.|......|.:.:|.:||.:|......:|...|::.            .|.:|::|.
Yeast   394 KIVSNLNYSQALVAKDSVAKFIYSALFDWLVENINTVL------------CNPAVNDQI------ 440

  Fly   845 ASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCINLCAETMQHFYNT 909
                                      ..|||:||::|||....:: .|..|||...|.:|..:|.
Yeast   441 --------------------------SSFIGVLDIYGFEHFEKNS-FEQFCINYANEKLQQEFNQ 478

  Fly   910 HIFKSSVESCRDEGIVCDTEVDYVDNVPCIDLISSLRTGLLSMLDAECSV-RGTAESYVTKLKVQ 973
            |:||...|....|.|.. :.:::.||.||||||.: :.|:||:||.|..: .|:.||:..||
Yeast   479 HVFKLEQEEYVKEEIEW-SFIEFNDNQPCIDLIEN-KLGILSLLDEESRLPAGSDESWTQKL--- 538

  Fly   974 HRSSTRLETKPTAEPHD-PRM----FLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGVFYKHTCNF 1033
               ...|:..||.:... ||.    |::.|:|..|.||...|::.|||.|.|..:.|. |.:.|.
Yeast   539 ---YQTLDKSPTNKVFSKPRFGQTKFIVSHYALDVAYDVEGFIEKNRDTVSDGHLEVL-KASTNE 599

  Fly  1034 GFATHLFGSELKALYAQQQAPRGLSFRISPTSHSDLLNGDEPVSTLTQDFHTRLDNLLRTLVHAR 1098
            .....|.|.| ||....::|.: |....:.:.....:.......||...|...|..|:.|:....
Yeast   600 TLINILEGLE-KAAKKLEEAKK-LELEQAGSKKPGPIRTVNRKPTLGSMFKQSLIELMNTINSTN 662

  Fly  1099 PHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETVNLMASGFPHRMRFKQFNARYRMLAP---F 1160
            .|::|||:.|..:.|..||...|:.|:|:..||||:.:..:|||.|..|::|..||.:|.|   :
Yeast   663 VHYIRCIKPNADKEAWQFDNLMVLSQLRACGVLETIRISCAGFPSRWTFEEFVLRYYILIPHEQW 727

  Fly  1161 RLLRRSEDKALEDCQLILKYAMEQPPVLDGSV--TLAWAPGKRHVFLSEGIRQHLEHLRTEIRHK 1223
            .|:.:.::...||...::|.      :||.:|  ...:..|...:|...|:..:||.||:...|.
Yeast   728 DLIFKKKETTEEDIISVVKM------ILDATVKDKSKYQIGNTKIFFKAGMLAYLEKLRSNKMHN 786

  Fly  1224 SATLMQATWRGWWWRKK 1240
            |..::|...|..::||:
Yeast   787 SIVMIQKKIRAKYYRKQ 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	215/772 (28%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	206/749 (28%)
MYO2	NP_014971.1	COG5022	2..1567	CDD:227355	223/797 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810