DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment d and MYO3

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_012793.2	Gene:	MYO3 / 853729	SGDID:	S000001612	Length:	1272	Species:	Saccharomyces cerevisiae

Alignment Length:	827	Identity:	210/827 - (25%)
Similarity:	344/827 - (41%)	Gaps:	155/827 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   475 MQDLIHLSGPLTEHAVMRTLQARFNERRYFTNVGPILLSINPYLDVG--NPLTLTSTRA---MPL 534
            :.||..|| .:::.::...|:.||.....:|.:|.:|:|:||:.|:|  ....|.|.:.   :.:
Yeast    38 ISDLTLLS-KISDESINENLKKRFKNGIIYTYIGHVLISVNPFRDLGIYTNAVLESYKGKNRLEV 101

  Fly   535 APQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGGGPET-DAFKHLAAA 598
            .|.:..|.:............|.:|:||.||||||..|..:::.:.|.:....|: ...|.:..|
Yeast   102 PPHVFAIAESMYYNLKSYNENQCVIISGESGAGKTEAAKRIMQYIAAASNSHSESIGKIKDMVLA 166

  Fly   599 FT-VLRSLGSAKTTTNSESSRIGQFIEVQVTD------GALYRTKIHCYFLDQTRVIRPLPKEKN 656
            .. :|.|.|.|||..|:.|||.|:::|::...      |     .|..|.|::.||:..:..|:|
Yeast   167 TNPLLESFGCAKTLRNNNSSRHGKYLEIKFNSQFEPCAG-----NITNYLLEKQRVVGQIKNERN 226

  Fly   657 YHIFYQLLAGLSREERQKLHLDGYSPANLRY------LRGDIGQNEQEDAARFQAWKTCLGILGI 715
            :|||||...|.|...:|...:.  .|....|      ...|...:.::.....:|.:| :|::..
Yeast   227 FHIFYQFTKGASDTYKQMFGVQ--MPEQYIYTAAAGCTTADTIDDVKDYEGTLEAMRT-IGLVQE 288

  Fly   716 PFLDVVRVLAAVLLLGNVQFIDG--GGLEVDVKGETELNS-VASLLGVPPAALFRGLTTR----T 773
            ....:.|:|||:|.:||:.||:.  |..:|   |:|.:.. ||.||.|..:.|.:.|..|    :
Yeast   289 EQDQIFRMLAAILWIGNISFIENEEGNAQV---GDTSVTDFVAYLLQVDASLLVKCLVERIMQTS 350

  Fly   774 HNV-RGQLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHNQ 837
            |.: ||.:.........|...||.||||:|......||.|.|
Yeast   351 HGMKRGSVYHVPLNPVQATAVRDALAKAIYNNLFDWIVDRVN----------------------- 392

  Fly   838 ADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCINLCAET 902
                              .|:.|...|      |..|||||::|| |...|...|.:|||...|.
Yeast   393 ------------------VSLQAFPGA------DKSIGILDIYGF-EIFEHNSFEQICINYVNEK 432

  Fly   903 MQHFYNTHIFKSSVESCRDEGIVCDTEVDYVDNVPCIDLISSLR-TGLL-----SMLDAECSVRG 961
            :|..:.....|:..|:...|.|.. |.:.|.||....|||.:.. .|:|     |:..|......
Yeast   433 LQQIFIQLTLKAEQETYEREKIKW-TPIKYFDNKVVCDLIEAKNPPGILAAMNDSIATAHADSNA 496

  Fly   962 TAESYVTKLKVQHRSSTRLETKPTAEPHDPRMFLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGVF 1026
            ..:::..:|.: ..|:...|.:       ...|:|:|:||.|.||.....|.|:|.:..||:.:
Yeast   497 ADQAFAQRLNL-FNSNPYFELR-------ANKFVIKHYAGDVTYDINGITDKNKDQLQKDLIEL- 552

  Fly  1027 YKHTCNFGFATHLFGSELKALYAQQQAPRGL---SFRISPTSHSDLLNGDEPVSTLTQDFHTRLD 1088
                  .|..|:.|   |..::     |..:   |.|..||:      ||:.:.:..:
Yeast   553 ------IGTTTNTF---LSTIF-----PDDVDKDSKRRPPTA------GDKIIKSANE------- 590

  Fly  1089 NLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETVNLMASGFPHRMRFKQFNAR 1153
             |:.||..|.|.::|.|:.|.|::...:|...|:.|::.|.:.|.|.:..:||.:|..|::|..|
Yeast   591 -LVETLSKAEPSYIRTIKPNQTKSPNDYDDHQVLHQVKYLGLQENVRIRRAGFAYRQTFEKFVER 654

  Fly  1154 YRMLAP---FRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVTLAWAPGKRHVFLSEGIRQHLEH 1215
            :.:|:|   :......:...||..:|||:.||.........||..:......:|.       ||.
Yeast   655 FYLLSPDCSYAGDYTWDGDTLEAVKLILRDAMIPEKEFQLGVTSVFIKTPESLFA-------LED 712

  Fly  1216 LRTEIRHKSATLMQATWRGWWWRK-----------KMGNGGAKRSKI 1251
            :|.:..:..|..:|..||.:..|:           :...||.|..|:
Yeast   713 MRDKYWYNMAARIQRAWRRFLQRRIDAAIKIQRTIREKKGGNKYVKL 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	200/779 (26%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	194/756 (26%)
MYO3	NP_012793.2	COG5022	1..1258	CDD:227355	210/827 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910