DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment d and XIE

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_175858.1	Gene:	XIE / 841898	AraportID:	AT1G54560	Length:	1529	Species:	Arabidopsis thaliana

Alignment Length:	799	Identity:	225/799 - (28%)
Similarity:	351/799 - (43%)	Gaps:	150/799 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   472 PKDMQ-------DLIHLSGPLTEHAVMRTLQARFNERRYFTNVGPILLSINPYL---DVGNPLTL 526
            ||||:       |:..|| .|.|..|::.|:.|:.....:|..|.||::|||:.   .:.:...:
plant    57 PKDMEAPAGGVDDMTKLS-YLHEPGVLQNLKIRYELNEIYTYTGNILIAINPFQRLPHIYDAHMM 120

  Fly   527 TSTRAMP---LAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGGGPE 588
            ...:..|   |:|.:..:...|.|.....|...:|::||.||||||....:::|.| |..||...
plant   121 QQYKGAPFGELSPHVFAVADVAYRAMINEGKSNSILVSGESGAGKTETTKMLMRYL-AYLGGRAV 184

  Fly   589 TD---AFKHLAAAFTVLRSLGSAKTTTNSESSRIGQFIEVQV-----TDGALYRTKIHCYFLDQT 645
            |:   ..:.:..:..||.:.|:|||..|:.|||.|:|:|:|.     ..||..||    |.|:::
plant   185 TEGRTVEQQVLESNPVLEAFGNAKTVRNNNSSRFGKFVEIQFDKQGRISGAAVRT----YLLERS 245

  Fly   646 RVIRPLPKEKNYHIFYQLLAGLSREERQKLHLDGYSPANLRYLRGDIGQNEQE--------DAAR 702
            ||.:....|:|||.|| ||....:||.:|..| |: |....||      |:.:        ||..
plant   246 RVCQISDPERNYHCFY-LLCAAPQEELEKYKL-GH-PKTFHYL------NQSKCFELVGISDAHD 301

  Fly   703 FQAWKTCLGILGIPFLD---VVRVLAAVLLLGNVQFIDG----GGLEVDVKGETELNSVASLLGV 760
            :.|.:..:.|:|:...:   :.||:||:|.||||:|..|    ..:..|.|.:..||:||.||..
plant   302 YIATRRAMDIVGMSEKEQEAIFRVVAAILHLGNVEFTKGKEVDSSVPKDDKSKFHLNTVAELLMC 366

  Fly   761 PPAALFRGLTTRTHNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGT 825
            ...||...|..|......:::|.......|.::||.|||.:|.|....:|.:.|
plant   367 DVKALEDALCKRVMVTPEEVIKRSLDPQSALISRDGLAKTIYSRLFDWLVEKIN----------- 420

  Fly   826 LSSDSNESVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAH 890
                                .:||                :.|||...||:||::|||....::
plant   421 --------------------VSIG----------------QDATSRSLIGVLDIYGFESFKTNS- 448

  Fly   891 LEHLCINLCAETMQHFYNTHIFKSSVESCRDEGIVCD-TEVDYVDNVPCIDLISSLRTGLLSMLD 954
            .|..|||...|.:|..:|.|:||...|....|.|  | :.:::|||...:|||.....|::::||
plant   449 FEQFCINFTNEKLQQHFNQHVFKMEQEEYTKEAI--DWSYIEFVDNQDVLDLIEKKPGGIVALLD 511

  Fly   955 AECSV-RGTAESYVTKLKVQHRSSTRLETKPTAEPHDPRMFLIRHFAGRVEYDTTDFLDTNRD-V 1017
            ..|.. :.|.|::..||....::..|. .||.....|   |.:.|:||.|:|.:..|||.|:| |
plant   512 EACMFPKSTHETFANKLYQTFKTHKRF-IKPKLSRTD---FAVAHYAGEVQYQSDLFLDKNKDYV 572

  Fly  1018 VPD--DLVGVFYKHTCNFGFATHLFGSELKALYAQQQAPRGLSFRISPTSHSDLLNGDEPVSTLT 1080
            :|:  ||:|.   ..|  .|...||..      ..::..:...|                 |::.
plant   573 IPEHQDLLGA---SKC--PFVVGLFPP------LPEETSKSSKF-----------------SSIG 609

  Fly  1081 QDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETVNLMASGFPHRM 1145
            ..|..:|..|:.||....||::||::.|.......|:...:::|:|...|||.:.:..:|:|.|.
plant   610 SRFKLQLQQLMETLNSTEPHYIRCVKPNNLLKPAVFENVNIMQQLRCGGVLEAIRISCAGYPTRK 674

  Fly  1146 RFKQFNARYRMLAPFRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVTLAWAPGKRHVFLSEGIR 1210
            .|.:|..|:.:|.|..|....|:||...            .:||......:..||..|||..|..
plant   675 PFFEFINRFGLLYPRALEGNYEEKAAAQ------------KILDNIGLKGYQVGKTKVFLRAGQM 727

  Fly  1211 QHLEHLRTEIRHKSATLMQ 1229
            ..|:..||.:...:|..:|
plant   728 AELDARRTMVLSAAAKKIQ 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	217/781 (28%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	209/751 (28%)
XIE	NP_175858.1	Myosin_N	14..51	CDD:280832
		MYSc	66..734	CDD:214580	217/776 (28%)
		MYSc_Myo11	79..723	CDD:276835	209/751 (28%)
		type_I_hlyD	723..>980	CDD:130902	6/24 (25%)
		ApoLp-III_like	<889..1026	CDD:304399
		TPR_MLP1_2	907..1054	CDD:285204
		bZIP	<1016..1052	CDD:304365
		MyosinXI_CBD	1114..1495	CDD:271259
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820