DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment d and XIH

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_194600.2	Gene:	XIH / 828991	AraportID:	AT4G28710	Length:	1516	Species:	Arabidopsis thaliana

Alignment Length:	1018	Identity:	263/1018 - (25%)
Similarity:	416/1018 - (40%)	Gaps:	226/1018 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   442 CQSVKTLPFGFGFSESQQKMQQQQQQGNSSPKDMQ-------DLIHLSGPLTEHAVMRTLQARFN 499
            |.|.||:..               :..::.|||::       |:..|: .|.|..|::.:::||:
plant    38 CTSGKTVAI---------------KVSSAYPKDVEAPASGVDDMTRLA-YLHEPGVLQNMKSRFD 86

  Fly   500 ERRYFTNVGPILLSINPYLDVGNPLTLTSTRAMP------------------LAPQLQKIVQEAV 546
            ....:|..|.||:::||:            |.:|                  |:|....:...|.
plant    87 INEIYTYTGNILIAVNPF------------RRLPHLYNNHMMQQYKGAGFGELSPHPFAVADAAY 139

  Fly   547 RQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGGGPETD---AFKHLAAAFTVLRSLGSA 608
            ||....|..|:|::||.||||||....|:: |..|..||...::   ..|.:..:..||.:.|:|
plant   140 RQMKNQGISQSILVSGESGAGKTETTKLLM-QYLADMGGRAVSEGRTVEKKVLESNPVLEAFGNA 203

  Fly   609 KTTTNSESSRIGQFIEVQVTD-GALYRTKIHCYFLDQTRVIRPLPKEKNYHIFYQLLAGLSREER 672
            ||..|:.|||.|:|:|:|... |.:....|..|.|:::||.:....|:|||.||.|.|. ..|:.
plant   204 KTVRNNNSSRFGKFVEIQFDQRGRISGAAIRTYLLERSRVCQVSDPERNYHCFYMLCAA-PPEDI 267

  Fly   673 QKLHLDGYSPANLRYLRGD--IGQNEQEDAARFQAWKTCLGILGIPFLD---VVRVLAAVLLLGN 732
            :|..|  ..|....||...  |.....:||..::..:..:.::||...:   :.:|:||:|.|||
plant   268 KKWKL--ADPRKFHYLNQSQCIELERMDDAKEYRETRKAMDVVGINSEEQEAIFQVVAAILHLGN 330

  Fly   733 VQFIDGGGLEVD---VKGET---ELNSVASLLGVPPAALFRGLTTRTHNVRGQLVKSVCGDGDAN 791
            |:|  |.|.|.|   .|.:|   .|.:.|.|......||...|..|....||:.:........|.
plant   331 VEF--GKGKEADSSAPKDDTSNYHLKTAAELFMCDEQALEDSLCKRVIVTRGETITKCLDQESAA 393

  Fly   792 MTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHNQADVASQHASTIGGGNAGSK 856
            ::||.|||.:|.|....||.:.                 |:|:....|
plant   394 LSRDALAKTVYSRLFDWIVNKI-----------------NDSIGQDPD----------------- 424

  Fly   857 SMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCINLCAETMQHFYNTHIFKSSVESCRD 921
                         |:..||:||::|||....:: .|..||||..|.:|..:|.|:||...:....
plant   425 -------------SEYLIGVLDIYGFESFKTNS-FEQFCINLTNEKLQQHFNQHVFKMEQDEYNK 475

  Fly   922 EGIVCD-TEVDYVDNVPCIDLISSLRTGLLSMLDAECSV-RGTAESYVTKLKVQHRSSTRLETKP 984
            |.|  | :.:::|||...:|||.....|::|:|:..|.. |.|.|::..|:....:..... :||
plant   476 EEI--DWSYIEFVDNQEILDLIEKKAGGIISLLNEACMFPRATHETFAEKMYQTFKDHKHF-SKP 537

  Fly   985 TAEPHDPRMFLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGVFYKHTCNFGFATHLFGSELKALYA 1049
            .....|   |.|.|:||.|.|.|..||:.|:|.|..:...:.....|  .|...||
plant   538 KLSRTD---FTICHYAGDVTYQTEQFLEKNKDYVVAEHQTLLNASRC--AFVASLF--------- 588

  Fly  1050 QQQAPRGLSFRISPTSHSDLLNGDEPVSTLTQDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAAR 1114
                         |....| .|.....|:::..|..:|..||.||....||::||::.|......
plant   589 -------------PLLAED-ANKKSKFSSISSRFKQQLVTLLETLSTTEPHYIRCVKPNNLLKPL 639

  Fly  1115 SFDRATVVRQIRSLQVLETVNLMASGFPHRMRFKQFNARYRMLAPFRLLRRSED----KALED-- 1173
            .|:...|::|:|...|:|.:.:..:|||.|.:|::|..|:.:||| .:|.:|.|    .:.:|
plant   640 IFENQNVLQQLRCGGVMEAIRISCAGFPTRKKFEEFLERFSVLAP-EVLDKSTDGWPLSSTDDVA 703

  Fly  1174 CQLIL-KYAMEQPPVLDGSVTLAWAPGKRHVFLSEGIRQHLEHLRTEIRHKSATLMQATWRGWWW 1237
            |:.:| |.|::           .:..||..|||..|....|:..|.|:..::|:.:|..:|.:..
plant   704 CKKLLEKVALQ-----------GYQIGKTKVFLRAGQMADLDARRNEVLGRAASRIQRKFRSYLS 757

  Fly  1238 RKKMGNGGAKRSKIPGLQQAPLPNNKTTPNSAAQNKAASSTMAALAAVAAAAPISVPR------- 1295
            ||..                 |...|...|..|..:...|.:........||.:.:.|
plant   758 RKTF-----------------LMLRKVATNMQAVCRGQLSRLIFEGLRRDAAVLEIQRDIRMHLA 805

  Fly  1296 --------LSAKTTSLGIGGTVARPRPQPIAGTPPPDPQEKCDQKIIQQTCNLF--GLDLERPPP 1350
                    .:|.:..|||.|..:|.|.:       ...|:|. ..:||..|..|  .|..:|
plant   806 RKSYKELYFAAVSIQLGIRGMASRGRLR-------FQRQDKA-AIMIQSHCRKFLAQLHYQR--- 859

  Fly  1351 VPPSRSYTITGNS----KISYPQNRVMKMNFPEEGQSEAPQLK 1389
               .:...||..|    :::..:.|.:||...|.|..||.:.|
plant   860 ---LKKAAITTQSAWRARLARKELRKLKMAAKETGVLEAAKSK 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	215/789 (27%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	208/759 (27%)
XIH	NP_194600.2	Myosin_N	12..47	CDD:280832	4/23 (17%)
		MYSc	56..738	CDD:214580	215/791 (27%)
		MYSc_Myo11	75..726	CDD:276835	208/759 (27%)
		Apolipoprotein	893..1041	CDD:279749	3/7 (43%)
		DUF4355	893..1011	CDD:290964	3/7 (43%)
		Ax_dynein_light	<978..1023	CDD:287215
		MyosinXI_CBD	1109..1486	CDD:271259
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820