DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment d and ATM1

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_001154628.2	Gene:	ATM1 / 821534	AraportID:	AT3G19960	Length:	1176	Species:	Arabidopsis thaliana

Alignment Length:	1048	Identity:	267/1048 - (25%)
Similarity:	418/1048 - (39%)	Gaps:	265/1048 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 PHMSGMGSILGQNSHSHAPVNNNSNNSNTLPMRTSNSG---HLGINGGGVGHHLSHAHSQQLP-- 431
            |.|..:.|:........:||::...||:...:|.:||.   ..|:..|......:...|:..|
plant     7 PFMQSLKSLPADYRFDGSPVSDRLENSSGASVRLTNSNVPRKGGLRNGVSRTDTAAGDSEDSPYS 71

  Fly   432 ----FIPQSKHTNPCQS-VKTLP--------FGFGFSESQQKMQQ---QQQQGN----------- 469
                |:.:...|:...| ..|:|        :....:.:::|:.|   |...||
plant    72 GHGVFVEEQSLTDDVDSGAATMPLPQSDERRWSDTSAYARKKILQSWIQLPNGNWELGKILSTSG 136

  Fly   470 -----SSPK--------------------DMQDLIHLSGPLTEHAVMRTLQARFNERRYFTNVGP 509
                 |.|:                    .:.||:.|| .|.|.:|:..|..|:|:...:|..||
plant   137 EESVISLPEGKVIKVISETLVPANPDILDGVDDLMQLS-YLNEPSVLYNLNYRYNQDMIYTKAGP 200

  Fly   510 ILLSINPYLDV---GNPLTLTSTRAMPLAPQLQKIVQEAVRQQSETGYPQAIIL----------- 560
            :|:::||:.:|   ||.......:....:|.:..|...|:|:.......|:||:
plant   201 VLVAVNPFKEVPLYGNRYIEAYRKKSNESPHVYAIADTAIREMIRDEVNQSIIIRCICIHESMTY 265

  Fly   561 -----SGTSGAGKTANAMLMLRQLFAIAGG-GPETDAFKHLAAAFTVLRSLGSAKTTTNSESSRI 619
                 ||.||||||..|.:.::.|.|:.|| |.|.:..|    ...:|.:.|:|||..|..|||.
plant   266 SISSSSGESGAGKTETAKIAMQYLAALGGGSGIEYEILK----TNPILEAFGNAKTLRNDNSSRF 326

  Fly   620 GQFIEVQVTD-GALYRTKIHCYFLDQTRVIRPLPKEKNYHIFYQLLAGLSREERQKLHLDGYSPA 683
            |:.||:..:: |.:...:|..:.|:::||::....|::|||||||.||.|...|:||:|.  |..
plant   327 GKLIEIHFSESGKISGAQIQTFLLEKSRVVQCAEGERSYHIFYQLCAGASPALREKLNLT--SAH 389

  Fly   684 NLRYLRGDIGQ------NEQEDAARFQAWKTCLGILGIPFLD---VVRVLAAVLLLGNVQF--ID 737
            ..:||    ||      |..:||.||...|..|.|:.:...|   |..:|||||.||||.|  ||
plant   390 EYKYL----GQSNCYSINGVDDAERFHTVKEALDIVHVSKEDQESVFAMLAAVLWLGNVSFTVID 450

  Fly   738 GGGLEVDVKGETE--------------------LNSVASLLGVPPAALFRGLTTRTHNVRGQLVK 782
            .......|..|:.                    |::||.|:|.....|...|:.|...||...:.
plant   451 NENHVEPVADESFLFHSLGSWCWKQECLLHNMCLSTVAKLIGCNINELTLTLSKRNMRVRNDTIV 515

  Fly   783 SVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHNQADVASQHAST 847
            .......|...||.|||::|......:|.:.|
plant   516 QKLTLPQAIDARDALAKSIYSCLFDWLVEQIN--------------------------------- 547

  Fly   848 IGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCINLCAETMQHFYNTHIF 912
                    ||:     ||....:...|.|||::|||....:: .|..|||...|.:|..:|.|:|
plant   548 --------KSL-----AVGKRRTGRSISILDIYGFESFDKNS-FEQFCINYANERLQQHFNRHLF 598

  Fly   913 KSSVESCRDEGIVCD-TEVDYVDNVPCIDLISSLRTGLLSMLDAECSV-RGTAESYVTKLKVQHR 975
            |...|....:||  | |.||:.||..|:.|......||||:||.|.:. .||..:...||| ||
plant   599 KLEQEEYIQDGI--DWTRVDFEDNQNCLSLFEKKPLGLLSLLDEESTFPNGTDLTLANKLK-QH- 659

  Fly   976 SSTRLETKPTAEPHDPRMFLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGVFYKHTCNFGFATHLF 1040
                |::.........::|.:.|:||.|.|:||.||:.|||::..|.:.:....:|   .....|
plant   660 ----LQSNSCFRGDKGKLFTVVHYAGEVTYETTGFLEKNRDLLHSDSIQLLSSCSC---LLPQAF 717

  Fly  1041 GSELKALYAQQQAPRGLSFRISPTSHSDLLNGDEPVSTLTQDFHTRLDNLLRTLVHARPHFVRCI 1105
            .|   ::..|.:.|     .:.|...:.  ..|....::...|.::|..|::.|.:..|||:|||
plant   718 AS---SMLIQSEKP-----VVGPLYKAG--GADSQRLSVATKFKSQLFQLMQRLGNTTPHFIRCI 772

  Fly  1106 RSNGTEAARSFDRATVVRQIRSLQVLETVNLMASGFPHRMRF-----KQFN---ARYRMLAPFRL 1162
            :.|..::...:::..|::|:|...|||   ::..| |::..|     .|||   ..|::......
plant   773 KPNNIQSPGVYEQGLVLQQLRCCGVLE---VLCKG-PYKRFFIIAILHQFNILPEMYQVGYTKLF 833

  Fly  1163 LRRSEDKALED--------------------CQLILKYAMEQPPVLDGSVTLAWAPGKRHVFLSE 1207
            .|..:...|||                    .:.:||.......:|...|.            .|
plant   834 FRTGQIGVLEDTRNRTLHGILRVQSSFRGYQARCLLKELKRGISILQSFVR------------GE 886

  Fly  1208 GIRQHLEHLRTEIRHKSA-----------------------TLMQATWRGWWWRKKMG------N 1243
            .||:....||.  |||:|                       .::|:..|||..|:..|      :
plant   887 KIRKEFAELRR--RHKAAATIQSQVKSKIARIQYKGIADASVVIQSAIRGWLVRRCSGDIGWLKS 949

  Fly  1244 GGAKRSKI 1251
            ||||.:::
plant   950 GGAKTNEL 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	225/822 (27%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	216/799 (27%)
ATM1	NP_001154628.2	MYSc	160..847	CDD:214580	218/769 (28%)
ATM1	NP_001154628.2	MYSc_Myo8	179..835	CDD:276834	208/737 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820