Protein Alignment d and MYO19

DIOPT Version :9

• Sequence 1: NP_001188730.1
• Gene: d / 34179
• FlyBaseID: FBgn0262029
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_011523588.1
• Gene: MYO19 / 80179
• HGNCID: 26234
• Length: 1047
• Species: Homo sapiens
• Alignment Length: 1130
• Identity: 270/1130 - (23%)
• Similarity: 435/1130 - (38%)
• Gaps: 361/1130 - (31%)

  Fly   475 MQDLIHLSGPLTEHAVMRTLQARFNERRYFTNVGPILLSINPYLDVG---NPLTLTSTRAMP--- 533
            :.||..:: |:|...|:|.||||:....::||.|..|:::||:..|.   :|..:....|.|
Human    37 LDDLTRVN-PVTLETVLRCLQARYMADTFYTNAGCTLVALNPFKPVPQLYSPELMREYHAAPQPQ 100

  Fly   534 --------------------------------LAPQLQKIVQEAVRQQSETGYP--QAIILSGTS 564
                                            |.|.:..:.::..|.......|  |:|::||.|
Human   101 QCGHSESASATACPIGAGRILNHEELTTGQKKLKPHVFTVGEQTYRNVKSLIEPVNQSIVVSGES 165

  Fly   565 GAGKTANAMLMLRQLFAIAGGGPETDAFKHLAAAF--------TVLRSLGSAKTTTNSESSRIGQ 621
            |||||..:..::: .:|:....|.:.....:|...        .|:.:.|:|.|..|:.|||.|:
Human   166 GAGKTWTSRCLMK-FYAVVATSPASWESHKIAERIEQRILNSNPVMEAFGNACTLRNNNSSRFGK 229

  Fly   622 FIEVQVT-----DGALYRTKIHCYFLDQTRVIRPLPKEKNYHIFYQLLAGLSREERQKLHLD--- 678
            ||::|:.     .||..:|    |.|::|||......|:|:|||||:..|.|.:||.:.||.
Human   230 FIQLQLNRAQQMTGAAVQT----YLLEKTRVACQASSERNFHIFYQICKGASEDERLQWHLPEGA 290

  Fly   679 --GYSPANLRYLRGD-----------IG-----QN-------EQEDAARFQAWKTCLGILGIPFL 718
              .:.|...|.|..|           :|     ||       ||::.....||::..|  | .|.
Human   291 AFSWLPNPERSLEEDCFEVTREAMLHLGIDTPTQNNIFKTAPEQQEGIDRMAWQSRKG--G-HFR 352

  Fly   719 DVV-----------------RVLAAVLLLGNVQF------------IDGGGLEVDVKGETELNSV 754
            :|.                 :|||.:|.|||:||            :|      |.|.|..:.:.
Human   353 EVAMQWKVTLTSRWGLLRHCQVLAGLLHLGNIQFAASEDEAQPCQPMD------DAKCEDSVRTA 411

  Fly   755 ASLLGVPPAALFRGLTTRTHNVRG----QLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANS 815
            |||||:|...|...:..||  :|.    |:.:..|...:.:..||||||.:|.|....:|
Human   412 ASLLGLPEDVLLEMVQIRT--IRAGRQQQVFRKPCARAECDTRRDCLAKLIYARLFDWLV----- 469

  Fly   816 LKRLGSTLGTLSSDSNESVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMF 880
                             ||.|.:..|...:.|.                        |||:||::
Human   470 -----------------SVINSSICADTDSWTT------------------------FIGLLDVY 493

  Fly   881 GFEEPSPHAHLEHLCINLCAETMQHFYNTHIFKSSVESCRDEGIVCDTEVDYVDNVPCIDLISSL 945
            |||. .|...||.||||...|.:|..:..|..::..|....||:.. :.::|.||.||:|||...
Human   494 GFES-FPDNSLEQLCINYANEKLQQHFVAHYLRAQQEEYAVEGLEW-SFINYQDNQPCLDLIEGS 556

  Fly   946 RTGLLSMLDAECSVRGTAESYVTKLKVQHRSSTRLETKPTAEP--------HDPRMFLIRHFAGR 1002
            ...:.|:::.||  |....|...:|:      ||:||.....|        .:| .|::.|:||.
Human   557 PISICSLINEEC--RLNRPSSAAQLQ------TRIETALAGSPCLGHNKLSREP-SFIVVHYAGP 612

  Fly  1003 VEYDTTDFLDTNRDVVPDDLVGVFYKHTCNFGFATHLFGSELKALYAQQQAPRGLSFRISPTSHS 1067
            |.|.|...::.|:|.:|                      .||..|..|.|.|  |...:.||:..
Human   613 VRYHTAGLVEKNKDPIP----------------------PELTRLLQQSQDP--LLMGLFPTNPK 653

  Fly  1068 DLLNGD------EPVSTLTQDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIR 1126
            :....:      .||.|:...|...|:.||:.|....||::|||:.|....|::|.:..|:.|:.
Human   654 EKTQEEPPGQSRAPVLTVVSKFKASLEQLLQVLHSTTPHYIRCIKPNSQGQAQTFLQEEVLSQLE 718

  Fly  1127 SLQVLETVNLMASGFPHRMRFKQFNARYRML------------APF------RLLRRSEDKALED 1173
            :..::||:::.|:|||.|:..:.|..||::|            :|:      .....||:..||.
Human   719 ACGLVETIHISAAGFPIRVSHRNFVERYKLLRRLHPCTSSGPDSPYPAKGLPEWCPHSEEATLEP 783

  Fly  1174 CQLILKYAMEQPPVLDGSVTLAW-------AP---GKRHVFLSEGIRQHLE-------------- 1214
               :::..:...|||..:..:..       ||   |:..||:::.:.:.||
Human   784 ---LIQDILHTLPVLTQAAAITGDSAEAMPAPMHCGRTKVFMTDSMLELLECGRARVLEQCARCI 845

  Fly  1215 --------HLRTEIRHKSATLMQATWRGW-------------------W--WRKKMGNGGAKRSK 1250
                    |...|.:.::..|:||..|.|                   |  ||.:|....||  :
Human   846 QGGWRRHRHREQERQWRAVMLIQAAIRSWLTRKHIQRLHAAATVIKRAWQKWRIRMACLAAK--E 908

  Fly  1251 IPGLQ-----QAPLPNNKTTPNSAAQNKAASSTMAALAAVAAAAPISVPRLSAKTTSLGIG---- 1306
            :.|::     |||.    :...|..|.:       .|.|:....|:.   |....|::|:|
Human   909 LDGVEEKHFSQAPC----SLSTSPLQTR-------LLEAIIRLWPLG---LVLANTAMGVGSFQR 959

  Fly  1307 -----GTVARPRPQP----------------IAGTPPPDPQEKCDQKIIQ--QTCNLFGLDLERP 1348
                 ..:..||..|                |...|....:..|.:..::  ..|         |
Human   960 KLVVWACLQLPRGSPSSYTVQTAQDQAGVTSIRALPQGSIKFHCRKSPLRYADIC---------P 1015

  Fly  1349 PPVPPSRSYTITGNSKISYPQNRVM 1373
            .|.|    |:|||.::|...::|::
Human  1016 EPSP----YSITGFNQILLERHRLI 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	229/918 (25%)
		MYSc_Myo20	488..1206	CDD:276847	222/873 (25%)
MYO19	XP_011523588.1	MYSc_Myo19	49..823	CDD:276846	222/873 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820