DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment d and Myh10

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_006534552.1	Gene:	Myh10 / 77579	MGIID:	1930780	Length:	2007	Species:	Mus musculus

Alignment Length:	909	Identity:	242/909 - (26%)
Similarity:	389/909 - (42%)	Gaps:	167/909 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 SQQLPFIPQSKHTNPCQSVKTLPFGFGFSESQQKMQQQQQQGNSSPKDMQDLIHLSGP------- 484
            :::|.:||..:|.....|:|.       ....:.|.:..:.|..:..:..|:..::.|
Mouse    32 AKKLVWIPSERHGFEAASIKE-------ERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVED 89

  Fly   485 ------LTEHAVMRTLQARFNERRYFTNVGPILLSINPYLDVGNPLTLTSTRAM-------PLAP 536
                  |.|.:|:..|:.|:.....:|..|...:.||||.::  |:...:...|       .:.|
Mouse    90 MAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNL--PIYSENIIEMYRGKKRHEMPP 152

  Fly   537 QLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGG---------------- 585
            .:..|.:.|.|...:....|:|:.:|.||||||.|...:::.|..:|..
Mouse   153 HIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPQESPKP 217

  Fly   586 -GPETDAFKHLAAAFTVLRSLGSAKTTTNSESSRIGQFIEV--QVTDGALYRTKIHCYFLDQTRV 647
             .|:.:..:.|..|..:|.|.|:|||..|..|||.|:||.:  .|| |.:....|..|.|:::|.
Mouse   218 VKPQGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVT-GYIVGANIETYLLEKSRA 281

  Fly   648 IRPLPKEKNYHIFYQLLAGLSREERQKLHLDGYSPANLRYL-RGDIGQNEQEDAARFQAWKTCLG 711
            :|....|:.:|||||||:|.....:..|.|:|::  |.|:| .|.|....|:|...||.....:.
Mouse   282 VRQAKDERTFHIFYQLLSGAGEHLKSDLLLEGFN--NYRFLSNGYIPIPGQQDKDNFQETMEAMH 344

  Fly   712 ILGI---PFLDVVRVLAAVLLLGNVQF-----IDGGGLEVDVKGETELNSVASLLGVPPAALFRG 768
            |:|.   ..|.:::|:::||..||:.|     .|    :..:...|....:..|||:......|.
Mouse   345 IMGFSHEEILSMLKVVSSVLQFGNISFKKERNTD----QASMPENTVAQKLCHLLGMNVMEFTRA 405

  Fly   769 LTTRTHNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNES 833
            :.|....|....|:.......|:...:.||||.|.|....:|.|.|.
Mouse   406 ILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINK------------------ 452

  Fly   834 VHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCINL 898
                                      ||:...|...|  ||||||:.|||....:: .|.||||.
Mouse   453 --------------------------ALDRTKRQGAS--FIGILDIAGFEIFELNS-FEQLCINY 488

  Fly   899 CAETMQHFYNTHIFKSSVESCRDEGIVCDTEVDY-VDNVPCIDLIS--SLRTGLLSMLDAEC-SV 959
            ..|.:|..:|..:|....|..:.|||..:. :|: :|..||||||.  :...|:|::||.|| ..
Mouse   489 TNEKLQQLFNHTMFILEQEEYQREGIEWNF-IDFGLDLQPCIDLIERPANPPGVLALLDEECWFP 552

  Fly   960 RGTAESYVTKLKVQHRSSTRLETKPTAEPHDPRMFLIRHFAGRVEYDTTDFLDTNRDVVPDDLVG 1024
            :.|.:::|.|| ||.:.|.....|| .:..|...|.|.|:||:|:|...::|..|.|.:.|::..
Mouse   553 KATDKTFVEKL-VQEQGSHSKFQKP-RQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNVAT 615

  Fly  1025 VFYKHTCNFGFATHLFGSELKALYAQQQAPRGLSFRISPTS-HS---DLLNGDEPVSTLTQD--- 1082
            :.  |..:..|...|:..|::.:   |:|    ||..|.:. |.   |.:.|.:.|:.:|:.
Mouse   616 LL--HQSSDRFVAELWKDEIQTI---QRA----SFYDSVSGLHEPPVDRIVGLDQVTGMTETAFG 671

  Fly  1083 ---------FHT-------RLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVL 1131
                     |.|       .|..|:.||.:..|:|||||..|..:.|...|...|:.|:|...||
Mouse   672 SAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVL 736

  Fly  1132 ETVNLMASGFPHRMRFKQFNARYRMLAPFRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVTLAW 1196
            |.:.:...|||:|:.|::|..||.:|.|..:.:...| ..:.|:.::: |:|..|.|       :
Mouse   737 EGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMD-GKQACERMIR-ALELDPNL-------Y 792

  Fly  1197 APGKRHVFLSEGIRQHLEHLR----TEIRHKSATLMQATWRGWWWRKKMGNGGAKRSKIPGLQQ 1256
            ..|:..:|...|:..|||..|    |:|    ....||..||:..||.......:.|.:..||:
Mouse   793 RIGQSKIFFRAGVLAHLEEERDLKITDI----IIFFQAVCRGYLARKAFAKKQQQLSALKVLQR 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	222/815 (27%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	214/779 (27%)
Myh10	XP_006534552.1	Myosin_N	33..72	CDD:397036	8/45 (18%)
		MYSc_Myh10	99..802	CDD:276952	214/779 (27%)
		Myosin_tail_1	879..1959	CDD:396244
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900