DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment d and Myo19

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	NP_079690.2	Gene:	Myo19 / 66196	MGIID:	1913446	Length:	963	Species:	Mus musculus

Alignment Length:	1040	Identity:	258/1040 - (24%)
Similarity:	429/1040 - (41%)	Gaps:	269/1040 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   464 QQQQGNSSPKDMQDLIHLSG----------------------PLTEHAVMRTLQARFNERRYFTN 506
            ||..|:|...|.:....|.|                      |:|...|:|.||||:.|..::||
Mouse     3 QQVNGHSLGSDAEGRASLKGDLREFLGGEIPLHQLDDLTKVNPVTLETVLRCLQARYTEDIFYTN 67

  Fly   507 VGPILLSINPYLDVGN---PLTLTSTRAMP----LAPQLQKIVQEAVRQQSETGYP--QAIILSG 562
            .|..|:::||:..|..   |..:....|.|    |.|.:..:.::..|.......|  |:|::||
Mouse    68 AGCTLVALNPFKHVPQLYAPELMQEYHAAPQPQKLKPHIFTVGEQTYRNVKSLIEPVNQSIVVSG 132

  Fly   563 TSGAGKTANAMLMLRQLFAIAGGGPETDAFKHLAA---------AFTVLRSLGSAKTTTNSESSR 618
            .||||||..:..::: .:|:....| |....|..|         :..|:.:.|:|.|..||.|||
Mouse   133 ESGAGKTWTSRCLMK-FYAVVAASP-TSCENHKIAERIEQRILNSNPVMEAFGNACTLRNSNSSR 195

  Fly   619 IGQFIEVQVT-----DGALYRTKIHCYFLDQTRVIRPLPKEKNYHIFYQLLAGLSREERQKLHL- 677
            .|:||::|:.     .||..:|    |.|::|||......|:|:|||||:..|.:::||.:.||
Mouse   196 FGKFIQLQLNRAQQMTGAAVQT----YLLEKTRVACQASSERNFHIFYQICKGATKDERLQWHLP 256

  Fly   678 DGYSPANLRYLRGDIGQNEQEDAARFQAWKTCLGILGIPF---LDVVRVLAAVLLLGNVQFIDG- 738
            :|.:.:.|......:    :||.  |:..:..:..|||..   .::.:|||.:|.||||.|:|.
Mouse   257 EGTAFSWLPNPESSL----EEDC--FEVTREAMLHLGIDTPTQNNIFKVLAGLLHLGNVHFVDSE 315

  Fly   739 -GGLEVDVKGETELN--SVASLLGVPPAALFRGLTTRTHNV--RGQLVKSVCGDGDANMTRDCLA 798
             ..|...|..:|:::  :.|.||.:|...|...:..||...  :.|:.:..|...:.:..|||||
Mouse   316 DEALPCQVMDDTKVSVRTSALLLQLPEKMLLESMQIRTIKAGKQQQVFQKPCSRAECDTRRDCLA 380

  Fly   799 KALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHNQADVASQHASTIGGGNAGSKSMAALNN 863
            |.:|.|....:|...||         ::.:|                         |||..|
Mouse   381 KLIYARLFDWLVSVINS---------SICAD-------------------------SKSWTA--- 408

  Fly   864 AVRHATSDGFIGILDMFGFEEPSPHAHLEHLCINLCAETMQHFYNTHIFKSSVESCRDEGIVCDT 928
                     |||:||::|||. .|:..||.||||...|.:|..:..|..::..|....||:.. :
Mouse   409 ---------FIGLLDVYGFES-FPNNSLEQLCINYANEKLQQHFVAHYLRAQQEEYEVEGLEW-S 462

  Fly   929 EVDYVDNVPCIDLISSLRTGLLSMLDAECSVRGTAESYVTKLKVQHRSSTRLETKP-------TA 986
            .|:|.||..|:||:......:.|:::.||.:...:.:    .::|.|..:.|..:|       :.
Mouse   463 FVNYQDNQTCLDLLEGSPISICSLINEECRLNRPSSA----AQLQTRIESTLAGRPCLGHNKLSR 523

  Fly   987 EPHDPRMFLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGVFYKHTCNFGFATHLFGSELKALYAQQ 1051
            ||    .|::.||||.|.|.|...::.|:|.||                      .||..|..|.
Mouse   524 EP----SFVVVHFAGPVRYHTAGLVEKNKDPVP----------------------PELTELLQQS 562

  Fly  1052 QAP-RGLSFRISPTSHS-DLLNGDE--PVSTLTQDFHTRLDNLLRTLVHARPHFVRCIRSNGTEA 1112
            |.| ..:.|..:|...: :.|:|..  |..|:...|...|:.||:.|.:..||::|||:.|....
Mouse   563 QDPLLTMLFPANPEEKTQEELSGQSRAPALTVVSKFKASLEQLLQVLHNTTPHYIRCIKPNSQSQ 627

  Fly  1113 ARSFDRATVVRQIRSLQVLETVNLMASGFPHRMRFKQFNARYRMLAPFRLLRRSEDKALEDCQ-- 1175
            .::|.:..|:.|:.:..::||:::.|:|||.|:..:.|..||::|........|....||..:
Mouse   628 PQTFLQEEVLNQLEACGLVETIHISAAGFPIRVSHQNFIERYKLLRRLGPRMSSGLGGLEPAEGS 692

  Fly  1176 ----LILKYAMEQPPVLD------GSVTLAWAP-------------GKRHVFLSEGIRQHLEHLR 1217
                |..|.|..||.:.|      ..:..|..|             |:..:|:::.:.:.||..|
Mouse   693 SEQPLCAKEATLQPLLQDILHALPALIQTAATPSDPAKNTQIPLYCGRTKIFMTDSMLELLECGR 757

  Fly  1218 TEI-------------RH---------KSATLMQATWRGW-------------------W--WRK 1239
            .::             ||         ::|.|:||.:|.|                   |  ||.
Mouse   758 AQMLEQCARCIQCGWRRHRLQKQEKQRRAAVLIQAAFRSWLTRKHIRRLHIAATVIKHAWHKWRI 822

  Fly  1240 KMGNGGAKRSKIPGLQQAPLPNNKTTPNSAAQNKAASSTMAALAAVAAAAPISVPRLSAKTTSLG 1304
            :|....:|  ::.|:::.|:|.   .|.:...:.:.:.| ..|.|:....|:.   |....::.|
Mouse   823 RMACLASK--ELDGMEEKPMPQ---APGTLRSSMSPAHT-RFLGAIIHLWPLG---LVLANSADG 878

  Fly  1305 IGGTVARPRPQPIAGTPPPDPQEKCDQKIIQQTCNLFGLDLERPPPVPPSRSYTITGNSKISYPQ 1369
            :.|                     ..:|::...|  ..|..:||             ::|:..||
Mouse   879 VRG---------------------FQRKLVAHAC--LRLPSDRP-------------SNKVQTPQ 907

Fly 1370 1369
Mouse 908 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	220/831 (26%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	214/786 (27%)
Myo19	NP_079690.2	MYSc_Myo19	49..746	CDD:276846	214/786 (27%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	602..624		9/21 (43%)
		IQ	784..804	CDD:366194	6/19 (32%)
		MyMOMA region. /evidence=ECO:0000250\|UniProtKB:Q96H55	829..963		20/124 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820