DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment d and myo5ab

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_009296049.2	Gene:	myo5ab / 565267	ZFINID:	ZDB-GENE-050411-72	Length:	1800	Species:	Danio rerio

Alignment Length:	850	Identity:	240/850 - (28%)
Similarity:	369/850 - (43%)	Gaps:	180/850 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   477 DLIHLSGPLTEHAVMRTLQARFNERR-YFTNVGPILLSINPY-------LDVGNPLTLTSTRAMP 533
            ||..|| .|.|.||:..|:.||.:.: .:|..|.||::||||       .|:.|  ..:......
Zfish    73 DLTALS-YLHEPAVLHNLRVRFTDSKLIYTYCGIILVAINPYESLPIYGSDIIN--AYSGQNMGD 134

  Fly   534 LAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGGGPETDAFKHLAAA 598
            :.|.:..:.:||.:|.:.....|:||:||.||||||.:|...:|....::....:....:.:.|:
Zfish   135 MDPHIFAVSEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVSESSDDASVEEKVLAS 199

  Fly   599 FTVLRSLGSAKTTTNSESSRIGQFIEVQVTD-----GALYRTKIHCYFLDQTRVIRPLPKEKNYH 658
            ..::.:.|:||||.|..|||.|::||:....     ||..||    |.|:::||:....:|:|||
Zfish   200 NPIMEAFGNAKTTRNDNSSRFGKYIEIGFDRKHHIIGANMRT----YLLEKSRVVFQASEERNYH 260

  Fly   659 IFYQLLAGLSREERQKLHL----------DGYSPANLRYLRGDIGQNEQEDAARFQAWKTCLGIL 713
            |||||.|.....|.:.|.|          .|.||.       .:|.|   |....||.:....:|
Zfish   261 IFYQLCACAHLPEFKPLKLGSADDFPYTNQGGSPV-------IVGVN---DLKEMQATRKAFSLL 315

  Fly   714 GIP---FLDVVRVLAAVLLLGNVQFIDGGGLEVDVKGE----------TELN--SVASLLGVPPA 763
            ||.   .:.:.::|:|:|.||||:..:.|.....:..|          ||::  |:|..|
Zfish   316 GITEAHQMGLFQILSAILHLGNVEVKERGSSSCSISDENGHLAMFCDLTEVSNESMAHWL----- 375

  Fly   764 ALFRGLTTRTHNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSS 828
             ..:.|.|.|..:...:.:....:|     ||.|||.:|.:..:.||.:.|.         .||:
Zfish   376 -CHKKLKTATETLNKPVTRLEAVNG-----RDALAKHIYAKLFSWIVSQVNK---------ALST 425

  Fly   829 DSNESVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEH 893
            .|..                                  |:    |||:||::|||....:: .|.
Zfish   426 SSKP----------------------------------HS----FIGVLDIYGFETFELNS-FEQ 451

  Fly   894 LCINLCAETMQHFYNTHIFKSSVESCRDEGIVCDTEVDYVDNVPCIDLISSLRTGLLSMLDAECS 958
            .|||...|.:|..:|.|:||...|....|.|.. |.:|:.||.|||:||.: :.|||.:||.||:
Zfish   452 FCINYANEKLQQQFNMHVFKLEQEEYMKEQIPW-TLIDFYDNQPCINLIEA-KMGLLDLLDEECT 514

  Fly   959 V-RGTAESYVTKLKVQH-RSSTRLETKPTAEPHDPRM----FLIRHFAGRVEYDTTDFLDTNRDV 1017
            : :|:.:|:..||...| :.|:..|        .|||    |:|.|||.:|||....||:.|:|.
Zfish   515 MPKGSDDSWAQKLYNTHLKKSSHFE--------KPRMSNKAFIILHFADKVEYQCDGFLEKNKDT 571

  Fly  1018 VPDDLVGVFYKHTCNFGFATHLFGSELKALYAQQQAPRG--------LSFRISPTSHSDLLNGDE 1074
            |.::.:.|.  ....|.....||..|.........|..|        .|||             |
Zfish   572 VNEEQINVL--KASKFSLLLELFQDEESPAAPNTTASSGRAKFGRSTQSFR-------------E 621

  Fly  1075 PVSTLTQDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETVNLMAS 1139
            ...::...|...|..|:.||....||:||||:.|..:|....|....|:|:|:..||||:.:.|:
Zfish   622 HKKSVGLQFRNSLHLLMETLNATTPHYVRCIKPNDVKAPFMMDPHRAVQQLRACGVLETIRISAA 686

  Fly  1140 GFPHRMRFKQFNARYRMLAPFRLLRRSE---DKALEDCQLILKYAMEQPPVLDGSVTLAWAPGKR 1201
            |||.|..:::|.:||::     |:.:.|   |:.| .||.:|:..::...        .:..||.
Zfish   687 GFPSRWTYQEFFSRYQV-----LMTKKEILLDRKL-TCQSVLERLVQNKD--------KYQFGKT 737

  Fly  1202 HVFLSEGIRQHLEHLRTEIRHKSATLMQATWRGWWWRKKMGNGGAKRSKIPGLQQAPLPNNKTTP 1266
            .:|...|...:||.||.:....:...:|.|.|.|          ..|.|...::||.:...|.|.
Zfish   738 KIFFRAGQVAYLEKLRADKLRTACIHIQKTIRCW----------LARMKYLRIRQAAITLQKYTR 792

  Fly  1267 NSAAQ 1271
            ...|:
Zfish   793 GHQAR 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	227/794 (29%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	218/772 (28%)
myo5ab	XP_009296049.2	Myosin_head	7..1324	CDD:332202	240/849 (28%)
		MYSc_Myo5	83..742	CDD:276831	218/772 (28%)
		Myo5-like_CBD	1427..1800	CDD:322280
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311886at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820