Protein Alignment dachs and MYO5C

DIOPT Version :10

• Sequence 1: NP_001188730.1
• Gene: dachs / 34179
• FlyBaseID: FBgn0262029
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_061198.2
• Gene: MYO5C / 55930
• HGNCID: 7604
• Length: 1742
• Species: Homo sapiens
• Alignment Length: 789
• Identity: 233/789 - (29%)
• Similarity: 354/789 - (44%)
• Gaps: 109/789 - (13%)

  Fly   477 DLIHLSGPLTEHAVMRTLQARFNERR-YFTNVGPILLSINPYLDV---GNPL--TLTSTRAMPLA 535
            ||..|| .|.|.||:..|:.||.|.: .:|..|.||:::|||..:   |:.:  ..:......:.
Human    71 DLTALS-YLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMGDMD 134

  Fly   536 PQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGGGPETDAFKHLAAAFT 600
            |.:..:.:||.:|.:.....|:||:||.||||||.:|...:|....::..|........:.|:..
Human   135 PHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSGSNAHVEDKVLASNP 199

  Fly   601 VLRSLGSAKTTTNSESSRIGQFIEVQVTD-GALYRTKIHCYFLDQTRVIRPLPKEKNYHIFYQLL 664
            :..::|:||||.|..|||.|::.|:...: ..:....:..|.|:::||:.....|:||||||||.
Human   200 ITEAVGNAKTTRNDNSSRFGKYTEISFDEQNQIIGANMSTYLLEKSRVVFQSENERNYHIFYQLC 264

  Fly   665 AGLSREERQKLHLDGYSPANLRYLRGDI---GQNEQEDAARFQAWKTCLGILGIPFLDVVRVLAA 726
            |...:.|.:.|.|......|...:.|:.   |.|::.:....|...|.||......:||.::|||
Human   265 ASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVNDRAEMVETQKTFTLLGFKEDFQMDVFKILAA 329

  Fly   727 VLLLGNVQFIDGGGLEVDV-KGETELNSVASLLGVPPAALFRGLTTRTHNVRGQLVKSVCGDGDA 790
            :|.|||||....|.....| :.::.|.....|||:....:.:.|..|......:.|........|
Human   330 ILHLGNVQITAVGNERSSVSEDDSHLKVFCELLGLESGRVAQWLCNRKIVTSSETVVKPMTRPQA 394

  Fly   791 NMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHNQADVASQHASTIGGGNAGS 855
            ...||.|||.:|......||.|.|...:..                    ..||.
Human   395 VNARDALAKKIYAHLFDFIVERINQALQFS--------------------GKQHT---------- 429

  Fly   856 KSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCINLCAETMQHFYNTHIFKSSVESCR 920
                             |||:||::|||....:: .|..|||...|.:|..:|.|:||...|...
Human   430 -----------------FIGVLDIYGFETFDVNS-FEQFCINYANEKLQQQFNMHVFKLEQEEYM 476

  Fly   921 DEGIVCDTEVDYVDNVPCIDLISSLRTGLLSMLDAECSV-RGTAESYVTKLKVQHRSSTRLETKP 984
            .|.|.. |.:|:.||.|.||||.: :.|:|.:||.||.: .||.|:::.||     .:..:...|
Human   477 KEDIPW-TLIDFYDNQPVIDLIEA-KMGILELLDEECLLPHGTDENWLQKL-----YNNFVNRNP 534

  Fly   985 TAEPHDPRM----FLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGVFYK---HTCNFGFATH---- 1038
            ..|  .|||    |:|:|||.:|||....||:.|||.|.|.||.:...   |.|...|..:
Human   535 LFE--KPRMSNTSFVIQHFADKVEYKCEGFLEKNRDTVYDMLVEILRASKFHLCANFFQENPTPP 597

  Fly  1039 -LFGSELKALYAQQQ-APRGLSFRISPTSHSDLLNGDEPVSTLTQDFHTRLDNLLRTLVHARPHF 1101
             .|||.:....|:|. .|....||                :|:...|.:.|..|:.||....||:
Human   598 SPFGSMITVKSAKQVIKPNSKHFR----------------TTVGSKFRSSLYLLMETLNATTPHY 646

  Fly  1102 VRCIRSNGTEAARSFDRATVVRQIRSLQVLETVNLMASGFPHRMRFKQFNARYRMLAPFRLLRRS 1166
            ||||:.|..:....||...:|:|:|:..||||:.:.|..:|.|..:.:|.:||.:|...:.|..|
Human   647 VRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYIEFYSRYGILMTKQELSFS 711

  Fly  1167 EDKALEDCQLILKYAMEQPPVLDGSVTLAWAPGKRHVFLSEGIRQHLEHLRTEIRHKSATLMQAT 1231
            :.|  |.|:::|...::.        :..:..||..:|...|...:||.||.:...:|..::|..
Human   712 DKK--EVCKVVLHRLIQD--------SNQYQFGKTKIFFRAGQVAYLEKLRLDKLRQSCVMVQKH 766

  Fly  1232 WRGWWWRKK 1240
            .|||..|||
Human   767 MRGWLQRKK 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dachs	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	214/742 (29%)
		IQCD	1219..1250	CDD:467745	8/22 (36%)
MYO5C	NP_061198.2	MYSc_Myo5	81..741	CDD:276831	214/742 (29%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	632..654		10/21 (48%)
		IQ	810..828	CDD:197470
		IQ	831..851	CDD:459869
		SMC_prok_B	<886..>1356	CDD:274008
		Myo5c_CBD	1369..1736	CDD:271260