DRSC/TRiP Functional Genomics Resources

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Protein Alignment d and MYO5C

DIOPT Version :9

Sequence 1:NP_001188730.1 Gene:d / 34179 FlyBaseID:FBgn0262029 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_061198.2 Gene:MYO5C / 55930 HGNCID:7604 Length:1742 Species:Homo sapiens


Alignment Length:789 Identity:233/789 - (29%)
Similarity:354/789 - (44%) Gaps:109/789 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   477 DLIHLSGPLTEHAVMRTLQARFNERR-YFTNVGPILLSINPYLDV---GNPL--TLTSTRAMPLA 535
            ||..|| .|.|.||:..|:.||.|.: .:|..|.||:::|||..:   |:.:  ..:......:.
Human    71 DLTALS-YLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMGDMD 134

  Fly   536 PQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGGGPETDAFKHLAAAFT 600
            |.:..:.:||.:|.:.....|:||:||.||||||.:|...:|....::..|........:.|:..
Human   135 PHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSGSNAHVEDKVLASNP 199

  Fly   601 VLRSLGSAKTTTNSESSRIGQFIEVQVTD-GALYRTKIHCYFLDQTRVIRPLPKEKNYHIFYQLL 664
            :..::|:||||.|..|||.|::.|:...: ..:....:..|.|:::||:.....|:||||||||.
Human   200 ITEAVGNAKTTRNDNSSRFGKYTEISFDEQNQIIGANMSTYLLEKSRVVFQSENERNYHIFYQLC 264

  Fly   665 AGLSREERQKLHLDGYSPANLRYLRGDI---GQNEQEDAARFQAWKTCLGILGIPFLDVVRVLAA 726
            |...:.|.:.|.|......|...:.|:.   |.|::.:....|...|.||......:||.::|||
Human   265 ASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVNDRAEMVETQKTFTLLGFKEDFQMDVFKILAA 329

  Fly   727 VLLLGNVQFIDGGGLEVDV-KGETELNSVASLLGVPPAALFRGLTTRTHNVRGQLVKSVCGDGDA 790
            :|.|||||....|.....| :.::.|.....|||:....:.:.|..|......:.|........|
Human   330 ILHLGNVQITAVGNERSSVSEDDSHLKVFCELLGLESGRVAQWLCNRKIVTSSETVVKPMTRPQA 394

  Fly   791 NMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHNQADVASQHASTIGGGNAGS 855
            ...||.|||.:|......||.|.|...:..                    ..||.          
Human   395 VNARDALAKKIYAHLFDFIVERINQALQFS--------------------GKQHT---------- 429

  Fly   856 KSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCINLCAETMQHFYNTHIFKSSVESCR 920
                             |||:||::|||....:: .|..|||...|.:|..:|.|:||...|...
Human   430 -----------------FIGVLDIYGFETFDVNS-FEQFCINYANEKLQQQFNMHVFKLEQEEYM 476

  Fly   921 DEGIVCDTEVDYVDNVPCIDLISSLRTGLLSMLDAECSV-RGTAESYVTKLKVQHRSSTRLETKP 984
            .|.|.. |.:|:.||.|.||||.: :.|:|.:||.||.: .||.|:::.||     .:..:...|
Human   477 KEDIPW-TLIDFYDNQPVIDLIEA-KMGILELLDEECLLPHGTDENWLQKL-----YNNFVNRNP 534

  Fly   985 TAEPHDPRM----FLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGVFYK---HTCNFGFATH---- 1038
            ..|  .|||    |:|:|||.:|||....||:.|||.|.|.||.:...   |.|...|..:    
Human   535 LFE--KPRMSNTSFVIQHFADKVEYKCEGFLEKNRDTVYDMLVEILRASKFHLCANFFQENPTPP 597

  Fly  1039 -LFGSELKALYAQQQ-APRGLSFRISPTSHSDLLNGDEPVSTLTQDFHTRLDNLLRTLVHARPHF 1101
             .|||.:....|:|. .|....||                :|:...|.:.|..|:.||....||:
Human   598 SPFGSMITVKSAKQVIKPNSKHFR----------------TTVGSKFRSSLYLLMETLNATTPHY 646

  Fly  1102 VRCIRSNGTEAARSFDRATVVRQIRSLQVLETVNLMASGFPHRMRFKQFNARYRMLAPFRLLRRS 1166
            ||||:.|..:....||...:|:|:|:..||||:.:.|..:|.|..:.:|.:||.:|...:.|..|
Human   647 VRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYIEFYSRYGILMTKQELSFS 711

  Fly  1167 EDKALEDCQLILKYAMEQPPVLDGSVTLAWAPGKRHVFLSEGIRQHLEHLRTEIRHKSATLMQAT 1231
            :.|  |.|:::|...::.        :..:..||..:|...|...:||.||.:...:|..::|..
Human   712 DKK--EVCKVVLHRLIQD--------SNQYQFGKTKIFFRAGQVAYLEKLRLDKLRQSCVMVQKH 766

  Fly  1232 WRGWWWRKK 1240
            .|||..|||
Human   767 MRGWLQRKK 775

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dNP_001188730.1 MYSc 476..1217 CDD:214580 223/764 (29%)
MYSc_Myo20 488..1206 CDD:276847 214/742 (29%)
MYO5CNP_061198.2 Myosin_N 12..48 CDD:280832
MYSc 62..752 CDD:214580 223/764 (29%)
MYSc_Myo5 81..741 CDD:276831 214/742 (29%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 632..654 10/21 (48%)
IQ 810..828 CDD:197470
COG1340 890..1150 CDD:224259
P-loop_NTPase <910..>1163 CDD:304359
GBP_C <927..1030 CDD:303769
coiled coil 997..1010 CDD:293879
coiled coil 1019..1030 CDD:293879
Rab5-bind 1020..1345 CDD:286404
DUF3585 1160..1326 CDD:304905
Myo5c_CBD 1369..1736 CDD:271260
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0160
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D311886at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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