DRSC/TRiP Functional Genomics Resources

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Protein Alignment d and MYO5B

DIOPT Version :9

Sequence 1:NP_001188730.1 Gene:d / 34179 FlyBaseID:FBgn0262029 Length:1426 Species:Drosophila melanogaster
Sequence 2:NP_001073936.1 Gene:MYO5B / 4645 HGNCID:7603 Length:1848 Species:Homo sapiens


Alignment Length:797 Identity:238/797 - (29%)
Similarity:375/797 - (47%) Gaps:119/797 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   477 DLIHLSGPLTEHAVMRTLQARFNERRY-FTNVGPILLSINPYLDVGNPL-------TLTSTRAMP 533
            ||..|| .|.|.||:..|:.||.|..: :|..|.:|::||||..:  |:       |.:......
Human    73 DLTALS-YLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQL--PIYGQDVIYTYSGQNMGD 134

  Fly   534 LAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGGGPETDAFKHLAAA 598
            :.|.:..:.:||.:|.:.....|:||:||.||||||.:|...:|....:.|...||:..:.:.|:
Human   135 MDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASETNIEEKVLAS 199

  Fly   599 FTVLRSLGSAKTTTNSESSRIGQFIEVQVTD-----GALYRTKIHCYFLDQTRVIRPLPKEKNYH 658
            ..::.::|:||||.|..|||.|::|::....     ||..||    |.|:::||:.....|:|||
Human   200 SPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIGANMRT----YLLEKSRVVFQADDERNYH 260

  Fly   659 IFYQLLAGLSREERQKLHLDGYSPANLRYLRGDIGQNEQEDAARFQAWKTCLGILGIP---FLDV 720
            |||||.|.....|.::|.|............||......:||..|:..:....:||:.   .:.:
Human   261 IFYQLCAAAGLPEFKELALTSAEDFFYTSQGGDTSIEGVDDAEDFEKTRQAFTLLGVKESHQMSI 325

  Fly   721 VRVLAAVLLLGNVQF---IDGGGLEVDVKGETELNSVASLLGVPPAALFRGL------TTRTHNV 776
            .:::|::|.||:|..   .||....:..: :..|::...||||..:.:...|      ||....|
Human   326 FKIIASILHLGSVAIQAERDGDSCSISPQ-DVYLSNFCRLLGVEHSQMEHWLCHRKLVTTSETYV 389

  Fly   777 RGQLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHNQADVA 841
            :...::.|..      .|:.|||.:|.:....||...|  |.|.::|                  
Human   390 KTMSLQQVIN------ARNALAKHIYAQLFGWIVEHIN--KALHTSL------------------ 428

  Fly   842 SQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCINLCAETMQHF 906
            .||:                           |||:||::|||....:: .|..|||...|.:|..
Human   429 KQHS---------------------------FIGVLDIYGFETFEVNS-FEQFCINYANEKLQQQ 465

  Fly   907 YNTHIFKSSVESCRDEGIVCDTEVDYVDNVPCIDLISSLRTGLLSMLDAECSV-RGTAESYVTKL 970
            :|:|:||...|....|.|.. |.:|:.||.||||||.: :.|:|.:||.||.| :||.:::..||
Human   466 FNSHVFKLEQEEYMKEQIPW-TLIDFYDNQPCIDLIEA-KLGILDLLDEECKVPKGTDQNWAQKL 528

  Fly   971 KVQHRSSTRLETKPTAEPHDPRM----FLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGVFYKHTC 1031
            ..:|.||...:        .|||    |:|.|||.:|||.:..||:.|||.|.::.:.:.  ...
Human   529 YDRHSSSQHFQ--------KPRMSNTAFIIVHFADKVEYLSDGFLEKNRDTVYEEQINIL--KAS 583

  Fly  1032 NFGFATHLFGSELKALYAQQQAPRGLSFRISPTSHSD--LLNGDEPVSTLTQDFHTRLDNLLRTL 1094
            .|.....||..:...:.|.... :|.|.:||..|...  .::..|...|:...|.|.|..|:.||
Human   584 KFPLVADLFHDDKDPVPATTPG-KGSSSKISVRSARPPMKVSNKEHKKTVGHQFRTSLHLLMETL 647

  Fly  1095 VHARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETVNLMASGFPHRMRFKQFNARYRMLAP 1159
            ....||:||||:.|..:....||....|:|:|:..||||:.:.|:|:|.|..:..|..|||:|..
Human   648 NATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWAYHDFFNRYRVLVK 712

  Fly  1160 FRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVTLAWAPGKRHVFLSEGIRQHLEHLRTEIRHKS 1224
            .|.|..::.||:  |:.:|:..::.|.        .:..|:..:|...|...:||.||.: :.::
Human   713 KRELANTDKKAI--CRSVLENLIKDPD--------KFQFGRTKIFFRAGQVAYLEKLRAD-KFRT 766

  Fly  1225 ATLM-QATWRGWWWRKK 1240
            ||:| |.|.|||..:.|
Human   767 ATIMIQKTVRGWLQKVK 783

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dNP_001188730.1 MYSc 476..1217 CDD:214580 227/771 (29%)
MYSc_Myo20 488..1206 CDD:276847 218/749 (29%)
MYO5BNP_001073936.1 Requires for interaction with LIMA1. /evidence=ECO:0000269|PubMed:29880681 21..40
MYSc 64..760 CDD:214580 227/771 (29%)
MYSc_Myo5 83..749 CDD:276831 218/749 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 596..630 7/34 (21%)
Actin-binding. /evidence=ECO:0000255 640..662 10/21 (48%)
IQ 860..881 CDD:197470
CCDC144C 895..1172 CDD:291576
RILP-like <980..1080 CDD:304877
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1093..1123
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1166..1192
Myo5b_CBD 1474..1845 CDD:271261
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0160
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D311886at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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