Protein Alignment dachs and MYO5A

DIOPT Version :10

• Sequence 1: NP_001188730.1
• Gene: dachs / 34179
• FlyBaseID: FBgn0262029
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_001369277.1
• Gene: MYO5A / 4644
• HGNCID: 7602
• Length: 1904
• Species: Homo sapiens
• Alignment Length: 827
• Identity: 244/827 - (29%)
• Similarity: 367/827 - (44%)
• Gaps: 153/827 - (18%)

  Fly   472 PKDMQDLIHLSGP--------------LTEHAVMRTLQARF-NERRYFTNVGPILLSINPY---- 517
            || .::|.||..|              |.|.||:..|:.|| :.:..:|..|.:|::||||
Human    78 PK-TKELPHLRNPDILVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTYCGIVLVAINPYEQLP 141

  Fly   518 ---LDVGNPLTLTSTRAMPLAPQLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQL 579
               .|:.|  ..:......:.|.:..:.:||.:|.:.....|:||:||.||||||.:|...:|..
Human   142 IYGEDIIN--AYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYF 204

  Fly   580 FAIAGGGPETDAFKHLAAAFTVLRSLGSAKTTTNSESSRIGQFIEVQVTD-----GALYRTKIHC 639
            ..::|...|.:..:.:.|:..::.|:|:||||.|..|||.|::||:....     ||..||
Human   205 ATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRT---- 265

  Fly   640 YFLDQTRVIRPLPKEKNYHIFYQLLAGLSREERQKLHLDGYSPANLRYLRGD---IGQNEQEDAA 701
            |.|:::||:....:|:||||||||.|.....|.:.|.|......|.....|.   .|.::.::.|
Human   266 YLLEKSRVVFQAEEERNYHIFYQLCASAKLPEFKMLRLGNADNFNYTKQGGSPVIEGVDDAKEMA 330

  Fly   702 RFQAWKTCLGILGIPFLDVVRVLAAVLLLGNVQFI--DGGGLEVDVKGETELNSVASLLGVPPAA 764
            ..:...|.|||.....:.:.|:||.:|.||||.|.  |.....:..|.| .|.....|:||....
Human   331 HTRQACTLLGISESHQMGIFRILAGILHLGNVGFTSRDADSCTIPPKHE-PLCIFCELMGVDYEE 394

  Fly   765 L-----FRGLTTRTHNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLG 824
            :     .|.|.|.|......:.|.     .|...||.|||.:|.:....||...|.
Human   395 MCHWLCHRKLATATETYIKPISKL-----QATNARDALAKHIYAKLFNWIVDNVNQ--------- 445

  Fly   825 TLSSDSNESVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHA 889
                                               ||::||:   ...|||:||::|||....::
Human   446 -----------------------------------ALHSAVK---QHSFIGVLDIYGFETFEINS 472

  Fly   890 HLEHLCINLCAETMQHFYNTHIFKSSVESCRDEGIVCDTEVDYVDNVPCIDLISSLRTGLLSMLD 954
             .|..|||...|.:|..:|.|:||...|....|.|.. |.:|:.||.|||:||.| :.|:|.:||
Human   473 -FEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPW-TLIDFYDNQPCINLIES-KLGILDLLD 534

  Fly   955 AECSV-RGTAESYVTKLKVQHRSSTRLETKPTAEPHDPRMFLIRHFAGRVEYDTTDFLDTNRDVV 1018
            .||.: :||.:::..||...|.:...|..||..   ..:.|:|:|||.:|||....||:.|:|.|
Human   535 EECKMPKGTDDTWAQKLYNTHLNKCALFEKPRL---SNKAFIIQHFADKVEYQCEGFLEKNKDTV 596

  Fly  1019 PDDLVGVFYKHTCNFGFATHLFGSELKALYAQQQAPRGLSFRISPTSHSDLLNGDEPVS------ 1077
            .::.:.|.  .:..|.....||..:.||              |||||.:.  :|..|::
Human   597 FEEQIKVL--KSSKFKMLPELFQDDEKA--------------ISPTSATS--SGRTPLTRTPAKP 643

  Fly  1078 --------------TLTQDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVVRQIRSL 1128
                          |:...|...|..|:.||....||:||||:.|..:...:||....|:|:|:.
Human   644 TKGRPGQMAKEHKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRAC 708

  Fly  1129 QVLETVNLMASGFPHRMRFKQFNARYRMLAPFRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVT 1193
            .||||:.:.|:|||.|..:::|.:|||:|       ..:...|.|.:...|..:|: .:||..
Human   709 GVLETIRISAAGFPSRWTYQEFFSRYRVL-------MKQKDVLSDRKQTCKNVLEK-LILDKD-- 763

  Fly  1194 LAWAPGKRHVFLSEGIRQHLEHLRTEIRHKSATLMQATWRGWWWRKK 1240
             .:..||..:|...|...:||.||.:....:...:|.|.|||..|||
Human   764 -KYQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKK 809

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dachs	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	223/761 (29%)
		IQCD	1219..1250	CDD:467745	8/22 (36%)
MYO5A	NP_001369277.1	COG5022	35..1472	CDD:227355	244/827 (30%)
		MYSc_Myo5	107..775	CDD:276831	223/761 (29%)
		Myo5a_CBD	1530..1904	CDD:271262