DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment d and MYH10

DIOPT Version :9

Sequence 1:	NP_001188730.1	Gene:	d / 34179	FlyBaseID:	FBgn0262029	Length:	1426	Species:	Drosophila melanogaster
Sequence 2:	XP_011522177.1	Gene:	MYH10 / 4628	HGNCID:	7568	Length:	2037	Species:	Homo sapiens

Alignment Length:	918	Identity:	240/918 - (26%)
Similarity:	382/918 - (41%)	Gaps:	185/918 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 SQQLPFIPQSKHTNPCQSVKTLPFGFGFSESQQKMQQQQQQGNSSPKDMQDLIHLSGP------- 484
            :::|.:||..:|.....|:|.       ....:.|.:..:.|..:..:..|:..::.|
Human    62 AKKLVWIPSERHGFEAASIKE-------ERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVED 119

  Fly   485 ------LTEHAVMRTLQARFNERRYFTNVGPILLSINPYLDVGNPLTLTSTRAM-------PLAP 536
                  |.|.:|:..|:.|:.....:|..|...:.||||.::  |:...:...|       .:.|
Human   120 MAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNL--PIYSENIIEMYRGKKRHEMPP 182

  Fly   537 QLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGG------------GPET 589
            .:..|.:.|.|...:....|:|:.:|.||||||.|...:::.|..:|..            .|:
Human   183 HIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPQESPK- 246

  Fly   590 DAFKH-------LAAAFTVLRSLGSAKTTTNSESSRIGQFIEV--QVTDGALYRTKIHCYFLDQT 645
             ..||       |..|..:|.|.|:|||..|..|||.|:||.:  .|| |.:....|..|.|:::
Human   247 -PVKHQGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVT-GYIVGANIETYLLEKS 309

  Fly   646 RVIRPLPKEKNYHIFYQLLAGLSREERQKLHLDGYSPANLRYL-RGDIGQNEQEDAARFQAWKTC 709
            |.:|....|:.:|||||||:|.....:..|.|:|::  |.|:| .|.|....|:|...||.....
Human   310 RAVRQAKDERTFHIFYQLLSGAGEHLKSDLLLEGFN--NYRFLSNGYIPIPGQQDKDNFQETMEA 372

  Fly   710 LGILGI---PFLDVVRVLAAVLLLGNVQF-----IDGGGLEVDVKGETELNSVASLLGVPPAALF 766
            :.|:|.   ..|.:::|:::||..||:.|     .|    :..:...|....:..|||:......
Human   373 MHIMGFSHEEILSMLKVVSSVLQFGNISFKKERNTD----QASMPENTVAQKLCHLLGMNVMEFT 433

  Fly   767 RGLTTRTHNVRGQLVKSVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSN 831
            |.:.|....|....|:.......|:...:.||||.|.|....:|.|.|.
Human   434 RAILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINK---------------- 482

  Fly   832 ESVHNQADVASQHASTIGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCI 896
                                        ||:...|...|  ||||||:.|||....:: .|.|||
Human   483 ----------------------------ALDRTKRQGAS--FIGILDIAGFEIFELNS-FEQLCI 516

  Fly   897 NLCAETMQHFYNTHIFKSSVESCRDEGIVCDTEVDY-VDNVPCIDLIS--SLRTGLLSMLDAEC- 957
            |...|.:|..:|..:|....|..:.|||..:. :|: :|..||||||.  :...|:|::||.||
Human   517 NYTNEKLQQLFNHTMFILEQEEYQREGIEWNF-IDFGLDLQPCIDLIERPANPPGVLALLDEECW 580

  Fly   958 SVRGTAESYVTKLKVQHRSSTRLETKPTAEPHDPRMFLIRHFAGRVEYDTTDFLDTNRDVVPDDL 1022
            ..:.|.:::|.|| ||.:.|.....|| .:..|...|.|.|:||:|:|...::|..|.|.:.|::
Human   581 FPKATDKTFVEKL-VQEQGSHSKFQKP-RQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNV 643

  Fly  1023 VGVFYKHTCNFGFATHLFGSELKALYAQQQAPRGLSFRISPTSHSDLLNG--DEPVS-------- 1077
            ..:.  |..:..|...|:..|::              .|...|..|.::|  :.||.
Human   644 ATLL--HQSSDRFVAELWKDEIQ--------------NIQRASFYDSVSGLHEPPVDRIVGLDQV 692

  Fly  1078 --------------------TLTQDFHTRLDNLLRTLVHARPHFVRCIRSNGTEAARSFDRATVV 1122
                                |:.|.:...|..|:.||.:..|:|||||..|..:.|...|...|:
Human   693 TGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVL 757

  Fly  1123 RQIRSLQVLETVNLMASGFPHRMRFKQFNARYRMLAPFRLLRRSEDKALEDCQLILKYAMEQPPV 1187
            .|:|...|||.:.:...|||:|:.|::|..||.:|.|..:.:...| ..:.|:.::: |:|..|.
Human   758 DQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMD-GKQACERMIR-ALELDPN 820

  Fly  1188 LDGSVTLAWAPGKRHVFLSEGIRQHLEHLR----TEIRHKSATLMQATWRGWWWRKKMGNGGAKR 1248
            |       :..|:..:|...|:..|||..|    |:|    ....||..||:..||.......:.
Human   821 L-------YRIGQSKIFFRAGVLAHLEEERDLKITDI----IIFFQAVCRGYLARKAFAKKQQQL 874

  Fly  1249 SKIPGLQQ 1256
            |.:..||:
Human   875 SALKVLQR 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
d	NP_001188730.1	MYSc	476..1217	CDD:214580	220/824 (27%)
d	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	212/788 (27%)
MYH10	XP_011522177.1	Myosin_N	64..102	CDD:280832	8/44 (18%)
		Myosin_head	117..832	CDD:278492	214/800 (27%)
		MYSc_Myh10	129..832	CDD:276952	212/788 (27%)
		Myosin_tail_1	909..1989	CDD:279860
		DUF342	<1105..1194	CDD:302792
		DUF2317	<1172..1283	CDD:302887
		COG5134	<1399..1527	CDD:227463
		GBP_C	<1565..1671	CDD:303769
		coiled coil	1661..1671	CDD:293879
		DUF106	<1706..>1757	CDD:303007
		DUF2570	1834..>1928	CDD:305162
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900