Protein Alignment dachs and MYO1B

DIOPT Version :10

• Sequence 1: NP_001188730.1
• Gene: dachs / 34179
• FlyBaseID: FBgn0262029
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: XP_047300366.1
• Gene: MYO1B / 4430
• HGNCID: 7596
• Length: 1156
• Species: Homo sapiens
• Alignment Length: 825
• Identity: 231/825 - (28%)
• Similarity: 368/825 - (44%)
• Gaps: 165/825 - (20%)

  Fly   477 DLIHLSGPLTEHAVMRTLQARFNERRYFTNVGPILLSINPY--LDVGNPLTLTSTR---AMPLAP 536
            |::.|. ||.|...:..|:.||:....:|.:|.:::|:|||  |.:.:|..:...|   ...|:|
Human    39 DMVLLE-PLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSP 102

  Fly   537 QLQKIVQEAVRQQSETGYPQAIILSGTSGAGKTANAMLMLRQLFAIAGGGPETDAFK-HLAAAFT 600
            .:..:..||.|...:....|.|:::|.||||||..:.|::..:.|:.|.|.|.:..| .|..:..
Human   103 HIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNP 167

  Fly   601 VLRSLGSAKTTTNSESSRIGQFIEVQVT-DGALYRTKIHCYFLDQTRVIRPLPKEKNYHIFYQLL 664
            ||.:.|:|||..|..|||.|::::::.. .|......|..|.|:::||::....|:|:|:|||||
Human   168 VLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLL 232

  Fly   665 AGLSREERQKLHLD-GYSPANLRYLRGDIGQ-NEQEDAARFQAWKTCLGILGIPFLD-----VVR 722
            :|.|.|...||.|: .:|..|  ||..|..: |..:|||.|:..:..:.|:|  |:|     |:.
Human   233 SGASEELLNKLKLERDFSRYN--YLSLDSAKVNGVDDAANFRTVRNAMQIVG--FMDHEAESVLA 293

  Fly   723 VLAAVLLLGNVQF-----IDGGGLEVDVKGETELNSVASLLGVPPAALFRGLTTRTHNVRGQLVK 782
            |:||||.|||::|     ::|.. |..:|.:.||..:..|.|:..:.|.|..:.||...:.:.|.
Human   294 VVAAVLKLGNIEFKPESRVNGLD-ESKIKDKNELKEICELTGIDQSVLERAFSFRTVEAKQEKVS 357

  Fly   783 SVCGDGDANMTRDCLAKALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHNQADVASQHAST 847
            :......|...||.|||.||.|..:.:|.|.                 |||:..|..|..:
Human   358 TTLNVAQAYYARDALAKNLYSRLFSWLVNRI-----------------NESIKAQTKVRKK---- 401

  Fly   848 IGGGNAGSKSMAALNNAVRHATSDGFIGILDMFGFEEPSPHAHLEHLCINLCAETMQHFYNTHIF 912
                                     .:|:||::|||....:: .|...||.|.|.:|..:.....
Human   402 -------------------------VMGVLDIYGFEIFEDNS-FEQFIINYCNEKLQQIFIELTL 440

  Fly   913 KSSVESCRDEGIVCDTEVDYVDNVPCIDLISSLRTGLLSMLDAECSVRGTA--ESYVTKLKVQHR 975
            |...|....|.|.. |.:||.:|....|||.:...|:|:|||.||...||.  |:::.||.....
Human   441 KEEQEEYIREDIEW-THIDYFNNAIICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCA 504

  Fly   976 SSTRLETK---------PTAEPHDPRMFLIRHFAGRVEYDTTDFLDTNRDVVPDDLVGVFYKHTC 1031
            :....|::         .|:.||.  .|.|:|:||:|.|....|:|.|.|::..||....:|
Human   505 THQHFESRMSKCSRFLNDTSLPHS--CFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWK--- 564

  Fly  1032 NFGFATHLFGSELKALYAQQQAPRGLSFRISPTSHSDLLNGDEPVSTLTQDFHTRLDNLLRTLVH 1096
                |:|..   :|:|:.:.. |..::.:..||:.|              .|...:..|::.|..
Human   565 ----ASHAL---IKSLFPEGN-PAKINLKRPPTAGS--------------QFKASVATLMKNLQT 607

  Fly  1097 ARPHFVRCIRSNGTEAARSFDRATVVRQIRSLQVLETVNLMASGFPHRMRFKQFNARYRML---- 1157
            ..|:::|||:.|..:||..|:.|.|..|||.|.:||.|.:..:|:..|..::....||:||
Human   608 KNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQT 672

  Fly  1158 -----APFRLLRRSEDKALEDCQLILKYAMEQPPVLDGSVTLAWAPGKRHVFLSEGIRQ-----H 1212
                 .|.|       ..:|    :|...:|.|       ...::.|:..:|    ||.     .
Human   673 WPHWKGPAR-------SGVE----VLFNELEIP-------VEEYSFGRSKIF----IRNPRTLFK 715

  Fly  1213 LEHLRTEIRHKSATLMQATWRGW------------------WWRK 1239
            ||.||.:.....|||:|..:|||                  |:|:
Human   716 LEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKKSQIVIAAWYRR 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dachs	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	211/756 (28%)
		IQCD	1219..1250	CDD:467745	9/39 (23%)
MYO1B	XP_047300366.1	MYSc_Myo1	49..708	CDD:276829	211/760 (28%)
		IQ	769..791	CDD:197470
		Myosin_TH1	961..1138	CDD:461801