Protein Alignment dachs and Mhcl

DIOPT Version :10

• Sequence 1: NP_001188730.1
• Gene: dachs / 34179
• FlyBaseID: FBgn0262029
• Length: 1426
• Species: Drosophila melanogaster
• Sequence 2: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Alignment Length: 1337
• Identity: 282/1337 - (21%)
• Similarity: 461/1337 - (34%)
• Gaps: 366/1337 - (27%)

  Fly   210 NITDASSSNEAVHLQQRLKSLSTELVTLRNRLHVGHGPGQGQSQGNGAQPV-APAPNAGPKANNF 273
            ::....|..|....|||       .:||......|..| ||.|||:....: :|:|:|....:..
  Fly   232 SVESLRSDGEQTGGQQR-------AMTLPANARYGALP-QGNSQGSHLHVLTSPSPSADSLTDTT 288

  Fly   274 DLNASSPNLNLSSSGAGLSASAVQQHTNGHHTTSKNHSF-------------------------- 312
            :.:.::|..:||..|          .:.|....::.|:|
  Fly   289 NSSFATPPFSLSPVG----------ESQGIDRWARVHAFEDVELPLPPVQLVKLPPPRQLVIRRQ 343

  Fly   313 ---------------------SHTLP-------ANSGSGGG--GGAGGGAVVSARNTSIPHPLPH 347
                                 |.|.|       |..|:|||  |...|..::....|.:.. ||.
  Fly   344 KSPRQDFGFSLRKAICLDRTESLTSPIFRPVIFAEPGAGGGATGLLPGDRLIKVNGTPVGE-LPR 407

  Fly   348 QLAEKPGLSHQQSGSGHGQSTGTLPHMSGMGSILGQNSHSHAP-------VNNNSNNSNTLPMRT 405
            ::     :......||...:....|    :..::..:....||       ::::..|.|...:|.
  Fly   408 EI-----IIEMIRNSGEAVTVEVQP----VAELVELSKRCMAPSTATVEEIDHSITNGNCNTLRR 463

  Fly   406 S-------NSGHLGINGG-------GVGHHLSH--AHSQQ-----------------LPFIPQSK 437
            |       .|.|...|||       ||||.|..  |.:.|                 ||.....:
  Fly   464 SASKRFKRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPERVWLVHRGGFTAAIRLPTASSGR 528

  Fly   438 HTNPCQSVKTLPFGFGFSESQQKMQQQQQQGNSSPKDM-QDLIHLSGPLTEHAVMRTLQARFNER 501
            ......|::.|..|...:..:..:::|    ||...|: :|:..|. .|.|.:|:..|:.|:...
  Fly   529 DEENKLSLRLLHNGEQLTVDEDDVEKQ----NSPALDLVEDICELK-YLNEASVLHCLRQRYASN 588

  Fly   502 RYFTNVGPILLSINPYLDVGNPLTLTS-----------TRAMPLAPQLQKIVQEAVRQQSETGYP 555
            ...|..||.||.:||..    ||:|.|           |..||  |.:..:.|.|.|...||...
  Fly   589 LIHTKAGPTLLVVNPMA----PLSLYSEKVVSMFRGCKTEDMP--PHVYSLAQTAYRSLVETRRD 647

  Fly   556 QAIILSGTSGAGKTANAMLMLRQLFAIAGGGPETDAFKHLAAAFTVLRSLGSAKTTTNSESSRIG 620
            |::|..|.||:||:.:....|..|...||........:.:.|..|:|.:.|:.||..||.::|:.
  Fly   648 QSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMT 712

  Fly   621 QFIEVQVTD-GALYRTKIHCYFLDQTRVIRPLPKEKNYHIFYQLLAGLSREERQKLHL------D 678
            |.:.:.... |.:....:.....::.|..|.|..|.::||..:||||.:...:::|||      |
  Fly   713 QLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSED 777

  Fly   679 GYSPANLRYLRGDIGQNEQEDAARFQAWKTCLGILGIPFLDVVRVLAAVL---LLGNVQFIDGGG 740
            .:...:|.....|..:...:.....||::| |.|.......:..:|||:.   :.|..:...|..
  Fly   778 SHPFISLSQKLEDRHRAANDFMRTVQAFET-LNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGST 841

  Fly   741 LEVDVKGETELNSVASLLGVP----PAALFRGLTTRTHNVRGQL--VKSVCGDGDANMTRDCLAK 799
            ........|.....:.||||.    .:|.| || |:.:...|.|  .||...|.......:||..
  Fly   842 ARTQFANPTAARKASGLLGVNLEDLSSAAF-GL-TQPNAPNGGLSPSKSPTSDTGHEWAWECLEA 904

  Fly   800 ---ALYCRTVATIVRRANSLKRLGSTLGTLSSDSNESVHNQADVASQHASTIGGGNAGSKSMAAL 861
               .||...:|.:|...|  :::.::..|::|
  Fly   905 LVIGLYSEALAAVVALIN--RQICTSSHTIAS--------------------------------- 934

  Fly   862 NNAVRHATSDGFIGILDMFGFEEPSP-----HAHLEHLCINLCAETMQH-FYNTHIF-------K 913
                        |.::|..||:.|:.     .|.|..|..|...|.:|. |::|.:.       :
  Fly   935 ------------IMLIDTPGFQNPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQ 987

  Fly   914 SSVESCRDEGIVCDTE--VDYVDNVPCIDLISSL--------RTGLLSMLDAECSV-RGTAESYV 967
            ..||...|....|...  :..:|..|...::.|.        |.|:|.:||.|... ....::::
  Fly   988 ELVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFL 1052

  Fly   968 TKL-----KVQHRSSTRLETKPTAEPHDPRMFLIRHFAGR--VEYDTTDFLDTNRD--------- 1016
            .:|     ..:|.|..|       :...||.|::.|..|.  |.|....::..:|:
  Fly  1053 ERLFSHYGDREHHSLLR-------KCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVS 1110

  Fly  1017 VVPD---DLVGVFYKHTCNFGFATHLFGSELKALYAQQQAPRGLSFRISPTSHSDLLNGDEPVST 1078
            ::.|   :.:...|..:...|....:|......|...|...|..|.|.|.|:     .|.:..|.
  Fly  1111 LLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTT-----AGVKRNSI 1170

  Fly  1079 LTQDFHTRLDNLLRTLVHARPHFVRC------------IRSNGTEAA--------RSFDRATVVR 1123
            :.|...| :|.::.||.....|||.|            ..:||:.::        .......::|
  Fly  1171 MLQVKFT-VDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLR 1234

  Fly  1124 -QIRSLQVLETVNLMASGFPHRMRFKQFNARYRMLAPFRLLRRSEDKALEDCQL-----ILKYAM 1182
             |:|..||||...|...|||..:...:|..|:.:||..  |..::|.::|....     :..|.:
  Fly  1235 SQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGD--LASNKDVSVEQILAVNELDVASYRI 1297

  Fly  1183 EQPPVLDGSVTLAWAPGKRHVFLSEGIRQHLEHLRTEIRHKSATLMQATWRGWWWRKKMGNGGAK 1247
            ....:|..|..|:....||.|.||:.|.|                :||..||:..||||.....:
  Fly  1298 GPSQILFRSGVLSELEAKRDVLLSDRIIQ----------------LQAFCRGYLARKKMSQRRVQ 1346

  Fly  1248 RSKIPGLQQ--------------------APLPN-NKTTPNSAAQN------------------- 1272
            ...:..:|:                    .||.| ::|.......|
  Fly  1347 ELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSE 1411

  Fly  1273 -KAASSTMAA--------LAAVAAAAPISVPRLSAKT 1300
             ||.:..:.|        ||...:.|.|:..||.|:|
  Fly  1412 VKAENQKLEAKLSELTVDLAEERSTAHIATERLEAET 1448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dachs	NP_001188730.1	MYSc_Myo20	488..1206	CDD:276847	182/816 (22%)
		IQCD	1219..1250	CDD:467745	8/30 (27%)
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948	15/94 (16%)
		COG5022	541..2019	CDD:227355	220/1000 (22%)
		MYSc_Myo18	575..1305	CDD:276837	177/800 (22%)